Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a–MET pathway

• Published in: EBioMedicine Vol. 40; pp. 432 - 445
• Main Authors: Wang, Guoying, Liu, Wei, Zou, Yong, Wang, Genshu, Deng, Yinan, Luo, Jingyan, Zhang, Yingcai, Li, Hua, Zhang, Qi, Yang, Yang, Chen, Guihua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2019; Elsevier
• Subjects: Advanced Basic Science; circPTGR1; Hepatocellular carcinoma; Internal Medicine; Metastasis; miR449a; Research paper; Hepatocellular carcinoma; Metastasis; circPTGR1; miR449a

The role of exosomal circular RNAs (circRNAs) in Hepatocellular carcinoma (HCC) cells with high metastatic potential has been little studied. Exosomal circRNA from cells with non-metastatic (HepG2), low metastatic (97L), and high metastatic (LM3) potential were sequencing. Metastatic-related circRNA...