Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice

• Published in: EBioMedicine Vol. 80; p. 104040
• Main Authors: Zhang, Wenjia, Liang, Xiaolong, Zhu, Liang, Zhang, Xinyu, Jin, Zhengyu, Du, Yang, Tian, Jie, Xue, Huadan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2022; Elsevier
• Subjects: Advanced Basic Science; Animals; Antineoplastic Agents - therapeutic use; Carcinoma, Pancreatic Ductal - diagnostic imaging; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Fluorescence molecular imaging (FMI); Humans; Internal Medicine; Magnetic particle imaging (MPI); Magnetic resonance imaging (MRI); Magnetic Resonance Imaging - methods; Mice; Multimodal Imaging; Pancreatic ductal adenocarcinoma (PDAC); Pancreatic Neoplasms; Pancreatic Neoplasms - drug therapy; Plectin; Superparamagnetic iron oxide nanoparticles (SPIONs); Magnetic particle imaging (MPI); Superparamagnetic iron oxide nanoparticles (SPIONs); Magnetic resonance imaging (MRI); Fluorescence molecular imaging (FMI); Pancreatic ductal adenocarcinoma (PDAC)

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study...