Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study...
Saved in:
| Published in | EBioMedicine Vol. 80; p. 104040 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.06.2022
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts.
The PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe3O4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation.
PTP-Fe3O4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe3O4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe3O4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes.
These data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy.
This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). |
|---|---|
| AbstractList | Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts.
The PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe
O
-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation.
PTP-Fe
O
-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe
O
-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe
O
-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe
O
-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe
O
-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes.
These data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy.
This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts.BACKGROUNDPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts.The PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe3O4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation.METHODSThe PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe3O4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation.PTP-Fe3O4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe3O4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe3O4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes.FINDINGSPTP-Fe3O4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe3O4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe3O4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes.These data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy.INTERPRETATIONThese data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy.This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02).FUNDINGThis study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts. Methods: The PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe3O4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation. Findings: PTP-Fe3O4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe3O4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe3O4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes. Interpretation: These data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy. Funding: This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts. The PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe3O4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation. PTP-Fe3O4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe3O4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe3O4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe3O4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe3O4-IRDye800CW: 74.41% ± 1.91%, **P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes. These data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy. This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). SummaryBackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI) is suitable for imaging deep and internal PDAC tumours because of its high sensitivity and unlimited imaging depth. The purpose of this study was to utilize the MPI, in combination with fluorescence molecular imaging (FMI) and magnetic resonance imaging (MRI), to advance the in vivo precise detection of PDAC xenografts. MethodsThe PDAC targeted plectin-1 peptide and IRDye800CW were conjugated to the superparamagnetic iron oxide nanoparticles (PTP-Fe 3O 4-IRDye800CW) for the PDAC-targeting triple-modality imaging. Subcutaneous and orthotopic PDAC mouse models were established. FMI, MPI, and MRI were performed for dynamic and quantitative observation of PDAC tumours. Histological staining analyses were used for ex vivo validation. FindingsPTP-Fe 3O 4-IRDye800CW nanoparticles possessed great triple-modality imaging performance and specific targeting to plectin-1 expressed on PDAC cells. For in vivo multi-modality imaging of orthotopic PDAC models, the PTP-Fe 3O 4-IRDye800CW nanoparticles demonstrated higher specificity, even distribution, and longer retention effects in tumours for over 7 d compared with Con-Fe 3O 4-IRDye800CW nanoparticles. (MPI, 2d post-injection: PTP-Fe 3O 4-IRDye800CW: 85.72% ± 1.53% vs. Con-Fe 3O 4-IRDye800CW: 74.41% ± 1.91%, ** P < 0.01 (Student's t test)). Ex vivo histological and Prussian blue stainings were performed to validate the distribution of probes. InterpretationThese data demonstrate the feasibility of utilizing MPI for in vivo PDAC imaging and complement with FMI/MRI for a precise and comprehensive in vivo characterization of PDAC. This may benefit PDAC patients for precise diagnosis and guidance of therapy. FundingThis study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). |
| ArticleNumber | 104040 |
| Author | Zhang, Xinyu Jin, Zhengyu Zhu, Liang Zhang, Wenjia Liang, Xiaolong Du, Yang Tian, Jie Xue, Huadan |
| Author_xml | – sequence: 1 givenname: Wenjia surname: Zhang fullname: Zhang, Wenjia organization: Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China – sequence: 2 givenname: Xiaolong surname: Liang fullname: Liang, Xiaolong organization: Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China – sequence: 3 givenname: Liang surname: Zhu fullname: Zhu, Liang organization: Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China – sequence: 4 givenname: Xinyu surname: Zhang fullname: Zhang, Xinyu organization: Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China – sequence: 5 givenname: Zhengyu surname: Jin fullname: Jin, Zhengyu email: jinzy@pumch.cn organization: Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China – sequence: 6 givenname: Yang surname: Du fullname: Du, Yang email: yang.du@ia.ac.cn organization: CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Road, Hai Dian District, Beijing 100190, China – sequence: 7 givenname: Jie orcidid: 0000-0003-0498-0432 surname: Tian fullname: Tian, Jie email: jie.tian@ia.ac.cn, tian@ieee.org organization: CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Road, Hai Dian District, Beijing 100190, China – sequence: 8 givenname: Huadan surname: Xue fullname: Xue, Huadan email: bjdanna95@hotmail.com organization: Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dong Cheng District, Beijing 100730, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35525203$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUstq3TAQNSWlSdN8QaF42Y1v9fCT0kAIfQQCWbRdC1ka-8q1JVeSA_db-rMd5yYhCbRBC4mZOedoZs7r5MA6C0nylpINJbT8MGygNW7aMMIYRnI8L5IjxguW8abMDx68D5OTEAZCCC1yDNavkkNeFKxghB8lf67maJQc00n2FvCZTssYzeS0HE3cpQbjxvap69J5BBWNzWgWpe8hgr7Pyh5sTDvn07iFdPagTIBUYw0inF3Rzseti25GhVla5UGuYnpREcWlBuuU9MpYN8nU2HQyCt4kLzs5Bji5vY-Tn18-_zj_ll1efb04P7vMVMlZzKjmZdMB7SrsEepcsbaEoqYlaVjVkKataklUVZW85W3dNEByDh2nLFctpYzy4-Riz6udHMTssSu_E04acRNwvhfS429HEC2rCeSs1p0u8pzINidc56zVugBWVgq5Tvdc89JOoBXOxcvxEenjjDVb0btr0ZCqqaoaCd7fEnj3e4EQxWSCgnGUFtwSBCtLSuqGFRWWvnuodS9yt10saPYFyrsQPHRCmSjXjaC0GQUlYjWTGMSNmcRqJrE3E2L5E-wd_f9Rn_YowH1dG_AiKANWgTZoiogDNc_gT5_g1WjsatBfsIMwuMVbtIKgIjBBxPfV5KvHGSPIQteWP_6b4Fn5vyo6DwQ |
| CitedBy_id | crossref_primary_10_1007_s00259_023_06202_7 crossref_primary_10_1109_TIM_2023_3328682 crossref_primary_10_1016_j_compbiomed_2024_108783 crossref_primary_10_1002_wnan_1983 crossref_primary_10_1021_acsnano_4c12263 crossref_primary_10_1088_1361_6560_ad19f0 crossref_primary_10_1007_s11307_023_01856_z crossref_primary_10_1021_acsami_3c00865 crossref_primary_10_1016_j_ejphar_2023_175729 crossref_primary_10_1016_j_ebiom_2023_104509 crossref_primary_10_1021_acs_analchem_4c04575 crossref_primary_10_1007_s11307_023_01812_x crossref_primary_10_1016_j_bspc_2023_104863 crossref_primary_10_1002_adfm_202214598 crossref_primary_10_1016_j_nantod_2025_102709 crossref_primary_10_4329_wjr_v15_i1_10 crossref_primary_10_1021_acs_bioconjchem_4c00266 crossref_primary_10_1002_adma_202311548 crossref_primary_10_1016_j_actbio_2022_12_062 crossref_primary_10_1186_s12951_024_02704_0 crossref_primary_10_5604_01_3001_0054_9363 crossref_primary_10_1007_s00259_024_06617_w |
| Cites_doi | 10.1200/JCO.2005.23.911 10.1021/nn3043463 10.1007/s10534-015-9845-9 10.1021/acs.nanolett.9b00630 10.2967/jnumed.119.233122 10.7150/thno.67375 10.1038/381290a0 10.3390/ijms20184504 10.1136/jitc-2021-003254 10.1002/adma.201700448 10.1021/acs.chemrev.5b00687 10.1007/s00259-021-05580-0 10.1001/jamasurg.2019.6033 10.3322/caac.21590 10.1016/j.nano.2011.08.017 10.1073/pnas.1100890108 10.1148/radiol.14132958 10.1007/s11307-018-1276-x 10.1021/acs.accounts.0c00518 10.1371/journal.pmed.0050085 10.1126/scitranslmed.aac6522 10.1038/nature03808 10.1186/s13045-021-01128-9 10.1016/j.msec.2019.110262 10.1158/1078-0432.CCR-16-1990 10.1007/s00441-004-0884-8 10.1002/adma.202107444 10.1038/s41571-021-00507-y 10.1002/adma.201200221 10.1021/acs.nanolett.0c04455 10.1021/acs.bioconjchem.5b00318 10.1039/D1NR08394E 10.1146/annurev.bioeng.9.060906.151929 10.1186/s12951-021-00963-9 10.2214/AJR.09.3107 10.1021/acsnano.9b01436 10.1002/jmri.26875 10.1158/1078-0432.CCR-10-0999 10.1007/s00259-020-04970-0 10.1155/2017/7659242 10.1021/acs.nanolett.6b04865 |
| ContentType | Journal Article |
| Copyright | 2022 The Authors The Authors Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. 2022 The Authors 2022 |
| Copyright_xml | – notice: 2022 The Authors – notice: The Authors – notice: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. – notice: 2022 The Authors 2022 |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.1016/j.ebiom.2022.104040 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2352-3964 |
| EndPage | 104040 |
| ExternalDocumentID | oai_doaj_org_article_b280e428dfd5440ab403d42bdd5e267c PMC9079778 35525203 10_1016_j_ebiom_2022_104040 S2352396422002213 1_s2_0_S2352396422002213 |
| Genre | Journal Article |
| GrantInformation | This study was funded by the National Natural Science Foundation of China (Grant No. 62027901, 82071896, 81871422, 81871514, 81227901), Ministry of Science and Technology of China under Grant No. 2017YFA0205200, 2017YFA0700401, Beijing Natural Science Foundation (Grant No. 7212207), Elite Program of Dong Cheng District of Beijing (2020-dchrcpyzz-28), and Peking University Third Hospital (BYSYZD2019018, and jyzc2018-02). |
| GroupedDBID | .1- .FO 0R~ 4.4 457 53G 5VS AAEDT AAEDW AAIKJ AALRI AAMRU AAXUO AAYWO ABMAC ACGFS ACVFH ADBBV ADCNI ADEZE ADRAZ ADVLN AEUPX AEXQZ AFPUW AFRHN AFTJW AGHFR AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV EBS EJD FDB GROUPED_DOAJ HYE HZ~ IPNFZ KQ8 M41 M48 O9- OK1 RIG ROL RPM SSZ Z5R 0SF 6I. AACTN AAFTH AFCTW NCXOZ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c632t-1d369fe1f7000e84c2b6e58160927909b78a0c7763b3b899e043ef3124cb11213 |
| IEDL.DBID | M48 |
| ISSN | 2352-3964 |
| IngestDate | Wed Aug 27 01:31:37 EDT 2025 Thu Aug 21 18:20:08 EDT 2025 Sun Aug 24 03:14:54 EDT 2025 Mon Jul 21 06:04:41 EDT 2025 Tue Jul 01 00:39:02 EDT 2025 Thu Apr 24 22:51:48 EDT 2025 Tue Jul 25 20:57:17 EDT 2023 Mon Feb 24 20:09:13 EST 2025 Tue Aug 26 16:33:52 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Magnetic particle imaging (MPI) Superparamagnetic iron oxide nanoparticles (SPIONs) Magnetic resonance imaging (MRI) Fluorescence molecular imaging (FMI) Pancreatic ductal adenocarcinoma (PDAC) |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c632t-1d369fe1f7000e84c2b6e58160927909b78a0c7763b3b899e043ef3124cb11213 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0003-0498-0432 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.ebiom.2022.104040 |
| PMID | 35525203 |
| PQID | 2661089257 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b280e428dfd5440ab403d42bdd5e267c pubmedcentral_primary_oai_pubmedcentral_nih_gov_9079778 proquest_miscellaneous_2661089257 pubmed_primary_35525203 crossref_citationtrail_10_1016_j_ebiom_2022_104040 crossref_primary_10_1016_j_ebiom_2022_104040 elsevier_sciencedirect_doi_10_1016_j_ebiom_2022_104040 elsevier_clinicalkeyesjournals_1_s2_0_S2352396422002213 elsevier_clinicalkey_doi_10_1016_j_ebiom_2022_104040 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-06-01 |
| PublicationDateYYYYMMDD | 2022-06-01 |
| PublicationDate_xml | – month: 06 year: 2022 text: 2022-06-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | EBioMedicine |
| PublicationTitleAlternate | EBioMedicine |
| PublicationYear | 2022 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Yu, Bishop, Zheng (bib0012) 2017; 17 Neiser, Rentsch, Dippon (bib0043) 2015; 28 Rosen, Chan, Shieh, Gu (bib0020) 2012; 8 Talebloo, Gudi, Robertson, Wang (bib0013) 2020; 51 Kelly, Bardeesy, Anbazhagan (bib0025) 2008; 5 Bazan-Peregrino, Garcia-Carbonero, Laquente (bib0034) 2021; 9 Achterberg, Deken, Meijer (bib0037) 2021; 48 Briley-Saebo, Bjornerud, Grant, Ahlstrom, Berg, Kindberg (bib0021) 2004; 316 Zeng, Pottler, Lan, Grutzmann, Pilarsky, Yang (bib0003) 2019; 20 Pang, Shi, Qin (bib0035) 2021; 14 Nejadnik, Pandit, Lenkov, Lahiji, Yerneni, Daldrup-Link (bib0044) 2019; 21 Kwon, Sevick-Muraca (bib0029) 2017; 2017 Wu, Mendoza-Garcia, Li, Sun (bib0014) 2016; 116 Siegel, Miller, Jemal (bib0001) 2020; 70 Eser, Messer, Eser (bib0004) 2011; 108 Natarajan, Mayer, Xu, Reeves, Gano, Gambhir (bib0028) 2015; 26 Miller, Gadde, Pfirschke (bib0041) 2015; 7 Sherry, Woods (bib0009) 2008; 10 Goodwill, Saritas, Croft (bib0015) 2012; 24 Hu, Chi, Wang (bib0005) 2017; 29 Zhang, Zeng, Liu (bib0016) 2022; 14 Lazaro-Carrillo, Filice, Guillen (bib0010) 2020; 107 Zhu, Wang, Chen (bib0030) 2022; 34 Willett, Czito, Bendell, Ryan (bib0002) 2005; 23 Du, Liu, Liang, Liang, Tian (bib0018) 2019; 19 Jie, Cai, Wang (bib0023) 2012; 7 Jiang, Han, Du (bib0017) 2021; 21 Kumar, Singh, Arora (bib0024) 2012; 7 Glazer (bib0027) 1996; 381 Ahmed, Solbiati, Brace (bib0031) 2014; 273 Melero, Castanon, Alvarez, Champiat, Marabelle (bib0039) 2021; 18 Bulte (bib0019) 2009; 193 Lee, Qian, Wang (bib0006) 2013; 7 Bausch, Thomas, Mino-Kenudson (bib0026) 2011; 17 Hsieh, Liang, Chieh (bib0022) 2012; 7 Cabral, Kinoh, Kataoka (bib0033) 2020; 53 Song, Zheng, Wang, Xia, Chu, Rao (bib0008) 2019; 13 Chen, Xie, Zhong (bib0038) 2020; 155 Gleich, Weizenecker (bib0011) 2005; 435 Wit, van Beurden, Kleinjan (bib0036) 2022; 49 Kato, Huang, Kadonaga (bib0032) 2021; 19 Watabe, Liu, Kaneda-Nakashima (bib0007) 2020; 61 Huang, Hsu, Koo, Cormode (bib0040) 2022; 12 Ramanathan, Korn, Raghunand (bib0042) 2017; 23 Rosen (10.1016/j.ebiom.2022.104040_bib0020) 2012; 8 Hu (10.1016/j.ebiom.2022.104040_bib0005) 2017; 29 Glazer (10.1016/j.ebiom.2022.104040_bib0027) 1996; 381 Gleich (10.1016/j.ebiom.2022.104040_bib0011) 2005; 435 Natarajan (10.1016/j.ebiom.2022.104040_bib0028) 2015; 26 Bazan-Peregrino (10.1016/j.ebiom.2022.104040_bib0034) 2021; 9 Zhang (10.1016/j.ebiom.2022.104040_bib0016) 2022; 14 Song (10.1016/j.ebiom.2022.104040_bib0008) 2019; 13 Bulte (10.1016/j.ebiom.2022.104040_bib0019) 2009; 193 Pang (10.1016/j.ebiom.2022.104040_bib0035) 2021; 14 Zeng (10.1016/j.ebiom.2022.104040_bib0003) 2019; 20 Watabe (10.1016/j.ebiom.2022.104040_bib0007) 2020; 61 Wit (10.1016/j.ebiom.2022.104040_bib0036) 2022; 49 Nejadnik (10.1016/j.ebiom.2022.104040_bib0044) 2019; 21 Zhu (10.1016/j.ebiom.2022.104040_bib0030) 2022; 34 Cabral (10.1016/j.ebiom.2022.104040_bib0033) 2020; 53 Huang (10.1016/j.ebiom.2022.104040_bib0040) 2022; 12 Talebloo (10.1016/j.ebiom.2022.104040_bib0013) 2020; 51 Ramanathan (10.1016/j.ebiom.2022.104040_bib0042) 2017; 23 Kwon (10.1016/j.ebiom.2022.104040_bib0029) 2017; 2017 Bausch (10.1016/j.ebiom.2022.104040_bib0026) 2011; 17 Yu (10.1016/j.ebiom.2022.104040_bib0012) 2017; 17 Chen (10.1016/j.ebiom.2022.104040_bib0038) 2020; 155 Melero (10.1016/j.ebiom.2022.104040_bib0039) 2021; 18 Eser (10.1016/j.ebiom.2022.104040_bib0004) 2011; 108 Jiang (10.1016/j.ebiom.2022.104040_bib0017) 2021; 21 Miller (10.1016/j.ebiom.2022.104040_bib0041) 2015; 7 Wu (10.1016/j.ebiom.2022.104040_bib0014) 2016; 116 Neiser (10.1016/j.ebiom.2022.104040_bib0043) 2015; 28 Kato (10.1016/j.ebiom.2022.104040_bib0032) 2021; 19 Briley-Saebo (10.1016/j.ebiom.2022.104040_bib0021) 2004; 316 Kumar (10.1016/j.ebiom.2022.104040_bib0024) 2012; 7 Ahmed (10.1016/j.ebiom.2022.104040_bib0031) 2014; 273 Sherry (10.1016/j.ebiom.2022.104040_bib0009) 2008; 10 Jie (10.1016/j.ebiom.2022.104040_bib0023) 2012; 7 Lazaro-Carrillo (10.1016/j.ebiom.2022.104040_bib0010) 2020; 107 Goodwill (10.1016/j.ebiom.2022.104040_bib0015) 2012; 24 Hsieh (10.1016/j.ebiom.2022.104040_bib0022) 2012; 7 Achterberg (10.1016/j.ebiom.2022.104040_bib0037) 2021; 48 Willett (10.1016/j.ebiom.2022.104040_bib0002) 2005; 23 Siegel (10.1016/j.ebiom.2022.104040_bib0001) 2020; 70 Du (10.1016/j.ebiom.2022.104040_bib0018) 2019; 19 Kelly (10.1016/j.ebiom.2022.104040_bib0025) 2008; 5 Lee (10.1016/j.ebiom.2022.104040_bib0006) 2013; 7 |
| References_xml | – volume: 49 start-page: 1743 year: 2022 end-page: 1753 ident: bib0036 article-title: The impact of drainage pathways on the detection of nodal metastases in prostate cancer: a phase II randomized comparison of intratumoral vs intraprostatic tracer injection for sentinel node detection publication-title: Eur J Nucl Med Mol Imaging – volume: 53 start-page: 2765 year: 2020 end-page: 2776 ident: bib0033 article-title: Tumor-targeted nanomedicine for immunotherapy publication-title: Acc Chem Res – volume: 316 start-page: 315 year: 2004 end-page: 323 ident: bib0021 article-title: Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging publication-title: Cell Tissue Res – volume: 7 start-page: 3503 year: 2012 end-page: 3516 ident: bib0024 article-title: Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells publication-title: Int J Nanomedicine – volume: 18 start-page: 558 year: 2021 end-page: 576 ident: bib0039 article-title: Intratumoural administration and tumour tissue targeting of cancer immunotherapies publication-title: Nat Rev Clin Oncol – volume: 21 start-page: 465 year: 2019 end-page: 472 ident: bib0044 article-title: Ferumoxytol can be used for quantitative magnetic particle imaging of transplanted stem cells publication-title: Mol Imaging Biol – volume: 23 start-page: 4538 year: 2005 end-page: 4544 ident: bib0002 article-title: Locally advanced pancreatic cancer publication-title: J Clin Oncol – volume: 13 start-page: 7750 year: 2019 end-page: 7758 ident: bib0008 article-title: A magneto-optical nanoplatform for multimodality imaging of tumors in mice publication-title: ACS Nano – volume: 14 start-page: 118 year: 2021 ident: bib0035 article-title: IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin publication-title: J Hematol Oncol – volume: 7 start-page: 2078 year: 2013 end-page: 2089 ident: bib0006 article-title: Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer publication-title: ACS Nano – volume: 23 start-page: 3638 year: 2017 end-page: 3648 ident: bib0042 article-title: Correlation between ferumoxytol uptake in tumor lesions by MRI and response to nanoliposomal irinotecan in patients with advanced solid tumors: a pilot study publication-title: Clin Cancer Res – volume: 107 year: 2020 ident: bib0010 article-title: Tailor-made PEG coated iron oxide nanoparticles as contrast agents for long lasting magnetic resonance molecular imaging of solid cancers publication-title: Mater Sci Eng C Mater Biol Appl – volume: 21 start-page: 2730 year: 2021 end-page: 2737 ident: bib0017 article-title: Mixed metal metal-organic frameworks derived carbon supporting ZnFe publication-title: Nano Lett – volume: 10 start-page: 391 year: 2008 end-page: 411 ident: bib0009 article-title: Chemical exchange saturation transfer contrast agents for magnetic resonance imaging publication-title: Annu Rev Biomed Eng – volume: 17 start-page: 302 year: 2011 end-page: 309 ident: bib0026 article-title: Plectin-1 as a novel biomarker for pancreatic cancer publication-title: Clin Cancer Res – volume: 61 start-page: 563 year: 2020 end-page: 569 ident: bib0007 article-title: Theranostics targeting fibroblast activation protein in the tumor stroma: (64)Cu- and (225)Ac-labeled FAPI-04 in pancreatic cancer xenograft mouse models publication-title: J Nucl Med – volume: 14 start-page: 3306 year: 2022 end-page: 3323 ident: bib0016 article-title: Recent development of a magneto-optical nanoplatform for multimodality imaging of pancreatic ductal adenocarcinoma publication-title: Nanoscale – volume: 19 start-page: 3618 year: 2019 end-page: 3626 ident: bib0018 article-title: Optimization and design of magnetic ferrite nanoparticles with uniform tumor distribution for highly sensitive MRI/MPI performance and improved magnetic hyperthermia therapy publication-title: Nano Lett – volume: 155 start-page: 300 year: 2020 end-page: 311 ident: bib0038 article-title: Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: a randomized clinical trial publication-title: JAMA Surg – volume: 273 start-page: 241 year: 2014 end-page: 260 ident: bib0031 article-title: Image-guided tumor ablation: standardization of terminology and reporting criteria–a 10-year update publication-title: Radiology – volume: 9 start-page: e003254 year: 2021 ident: bib0034 article-title: VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects publication-title: J Immunother Cancer – volume: 24 start-page: 3870 year: 2012 end-page: 3877 ident: bib0015 article-title: X-space MPI: magnetic nanoparticles for safe medical imaging publication-title: Adv Mater – volume: 17 start-page: 1648 year: 2017 end-page: 1654 ident: bib0012 article-title: Magnetic particle imaging: a novel publication-title: Nano Lett – volume: 34 year: 2022 ident: bib0030 article-title: An enzyme-activatable aggregation-induced-emission probe: intraoperative pathological fluorescent diagnosis of pancreatic cancer via specific cathepsin E publication-title: Adv Mater – volume: 8 start-page: 275 year: 2012 end-page: 290 ident: bib0020 article-title: Iron oxide nanoparticles for targeted cancer imaging and diagnostics publication-title: Nanomedicine – volume: 435 start-page: 1214 year: 2005 end-page: 1217 ident: bib0011 article-title: Tomographic imaging using the nonlinear response of magnetic particles publication-title: Nature – volume: 381 start-page: 290 year: 1996 ident: bib0027 article-title: Bioconjugate techniques - Hermanson, GT publication-title: Nature – volume: 7 start-page: 3981 year: 2012 end-page: 3989 ident: bib0023 article-title: Actively-targeted LTVSPWY peptide-modified magnetic nanoparticles for tumor imaging publication-title: Int J Nanomedicine – volume: 12 start-page: 796 year: 2022 end-page: 816 ident: bib0040 article-title: Repurposing ferumoxytol: diagnostic and therapeutic applications of an FDA-approved nanoparticle publication-title: Theranostics – volume: 7 start-page: 314ra183 year: 2015 ident: bib0041 article-title: Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle publication-title: Sci Transl Med – volume: 108 start-page: 9945 year: 2011 end-page: 9950 ident: bib0004 article-title: diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging publication-title: Proc Natl Acad Sci U S A – volume: 19 start-page: 223 year: 2021 ident: bib0032 article-title: Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy publication-title: J Nanobiotechnol – volume: 20 start-page: 4504 year: 2019 ident: bib0003 article-title: Chemoresistance in pancreatic cancer publication-title: Int J Mol Sci – volume: 7 start-page: 2833 year: 2012 end-page: 2842 ident: bib0022 article-title: tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles publication-title: Int J Nanomedicine – volume: 48 start-page: 332 year: 2021 end-page: 339 ident: bib0037 article-title: Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery publication-title: Eur J Nucl Med Mol Imaging – volume: 116 start-page: 10473 year: 2016 end-page: 10512 ident: bib0014 article-title: Organic phase syntheses of magnetic nanoparticles and their applications publication-title: Chem Rev – volume: 2017 year: 2017 ident: bib0029 article-title: Effects of depilation-induced skin pigmentation and diet-induced fluorescence on publication-title: Contrast Media Mol Imaging – volume: 29 start-page: 1700448 year: 2017 ident: bib0005 article-title: A comparative study of clinical intervention and interventional photothermal therapy for pancreatic cancer publication-title: Adv Mater – volume: 26 start-page: 2062 year: 2015 end-page: 2069 ident: bib0028 article-title: Novel radiotracer for ImmunoPET imaging of PD-1 checkpoint expression on tumor infiltrating lymphocytes publication-title: Bioconjug Chem – volume: 28 start-page: 615 year: 2015 end-page: 635 ident: bib0043 article-title: Physico-chemical properties of the new generation IV iron preparations ferumoxytol, iron isomaltoside 1000 and ferric carboxymaltose publication-title: Biometals – volume: 70 start-page: 7 year: 2020 end-page: 30 ident: bib0001 article-title: Cancer statistics, 2020 publication-title: CA Cancer J Clin – volume: 51 start-page: 1659 year: 2020 end-page: 1668 ident: bib0013 article-title: Magnetic particle imaging: current applications in biomedical research publication-title: J Magn Reson Imaging – volume: 193 start-page: 314 year: 2009 end-page: 325 ident: bib0019 article-title: MRI cell tracking: clinical studies publication-title: AJR Am J Roentgenol – volume: 5 start-page: e85 year: 2008 ident: bib0025 article-title: Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma publication-title: PLoS Med – volume: 23 start-page: 4538 issue: 20 year: 2005 ident: 10.1016/j.ebiom.2022.104040_bib0002 article-title: Locally advanced pancreatic cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2005.23.911 – volume: 7 start-page: 2078 issue: 3 year: 2013 ident: 10.1016/j.ebiom.2022.104040_bib0006 article-title: Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer publication-title: ACS Nano doi: 10.1021/nn3043463 – volume: 28 start-page: 615 issue: 4 year: 2015 ident: 10.1016/j.ebiom.2022.104040_bib0043 article-title: Physico-chemical properties of the new generation IV iron preparations ferumoxytol, iron isomaltoside 1000 and ferric carboxymaltose publication-title: Biometals doi: 10.1007/s10534-015-9845-9 – volume: 19 start-page: 3618 issue: 6 year: 2019 ident: 10.1016/j.ebiom.2022.104040_bib0018 article-title: Optimization and design of magnetic ferrite nanoparticles with uniform tumor distribution for highly sensitive MRI/MPI performance and improved magnetic hyperthermia therapy publication-title: Nano Lett doi: 10.1021/acs.nanolett.9b00630 – volume: 61 start-page: 563 issue: 4 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0007 article-title: Theranostics targeting fibroblast activation protein in the tumor stroma: (64)Cu- and (225)Ac-labeled FAPI-04 in pancreatic cancer xenograft mouse models publication-title: J Nucl Med doi: 10.2967/jnumed.119.233122 – volume: 12 start-page: 796 issue: 2 year: 2022 ident: 10.1016/j.ebiom.2022.104040_bib0040 article-title: Repurposing ferumoxytol: diagnostic and therapeutic applications of an FDA-approved nanoparticle publication-title: Theranostics doi: 10.7150/thno.67375 – volume: 381 start-page: 290 issue: 6580 year: 1996 ident: 10.1016/j.ebiom.2022.104040_bib0027 article-title: Bioconjugate techniques - Hermanson, GT publication-title: Nature doi: 10.1038/381290a0 – volume: 20 start-page: 4504 issue: 18 year: 2019 ident: 10.1016/j.ebiom.2022.104040_bib0003 article-title: Chemoresistance in pancreatic cancer publication-title: Int J Mol Sci doi: 10.3390/ijms20184504 – volume: 9 start-page: e003254 issue: 11 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0034 article-title: VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects publication-title: J Immunother Cancer doi: 10.1136/jitc-2021-003254 – volume: 29 start-page: 1700448 issue: 33 year: 2017 ident: 10.1016/j.ebiom.2022.104040_bib0005 article-title: A comparative study of clinical intervention and interventional photothermal therapy for pancreatic cancer publication-title: Adv Mater doi: 10.1002/adma.201700448 – volume: 116 start-page: 10473 issue: 18 year: 2016 ident: 10.1016/j.ebiom.2022.104040_bib0014 article-title: Organic phase syntheses of magnetic nanoparticles and their applications publication-title: Chem Rev doi: 10.1021/acs.chemrev.5b00687 – volume: 49 start-page: 1743 issue: 5 year: 2022 ident: 10.1016/j.ebiom.2022.104040_bib0036 article-title: The impact of drainage pathways on the detection of nodal metastases in prostate cancer: a phase II randomized comparison of intratumoral vs intraprostatic tracer injection for sentinel node detection publication-title: Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-021-05580-0 – volume: 155 start-page: 300 issue: 4 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0038 article-title: Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: a randomized clinical trial publication-title: JAMA Surg doi: 10.1001/jamasurg.2019.6033 – volume: 70 start-page: 7 issue: 1 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0001 article-title: Cancer statistics, 2020 publication-title: CA Cancer J Clin doi: 10.3322/caac.21590 – volume: 8 start-page: 275 issue: 3 year: 2012 ident: 10.1016/j.ebiom.2022.104040_bib0020 article-title: Iron oxide nanoparticles for targeted cancer imaging and diagnostics publication-title: Nanomedicine doi: 10.1016/j.nano.2011.08.017 – volume: 108 start-page: 9945 issue: 24 year: 2011 ident: 10.1016/j.ebiom.2022.104040_bib0004 article-title: In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1100890108 – volume: 273 start-page: 241 issue: 1 year: 2014 ident: 10.1016/j.ebiom.2022.104040_bib0031 article-title: Image-guided tumor ablation: standardization of terminology and reporting criteria–a 10-year update publication-title: Radiology doi: 10.1148/radiol.14132958 – volume: 21 start-page: 465 issue: 3 year: 2019 ident: 10.1016/j.ebiom.2022.104040_bib0044 article-title: Ferumoxytol can be used for quantitative magnetic particle imaging of transplanted stem cells publication-title: Mol Imaging Biol doi: 10.1007/s11307-018-1276-x – volume: 53 start-page: 2765 issue: 12 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0033 article-title: Tumor-targeted nanomedicine for immunotherapy publication-title: Acc Chem Res doi: 10.1021/acs.accounts.0c00518 – volume: 5 start-page: e85 issue: 4 year: 2008 ident: 10.1016/j.ebiom.2022.104040_bib0025 article-title: Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma publication-title: PLoS Med doi: 10.1371/journal.pmed.0050085 – volume: 7 start-page: 314ra183 issue: 314 year: 2015 ident: 10.1016/j.ebiom.2022.104040_bib0041 article-title: Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aac6522 – volume: 435 start-page: 1214 issue: 7046 year: 2005 ident: 10.1016/j.ebiom.2022.104040_bib0011 article-title: Tomographic imaging using the nonlinear response of magnetic particles publication-title: Nature doi: 10.1038/nature03808 – volume: 14 start-page: 118 issue: 1 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0035 article-title: IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin publication-title: J Hematol Oncol doi: 10.1186/s13045-021-01128-9 – volume: 7 start-page: 3981 year: 2012 ident: 10.1016/j.ebiom.2022.104040_bib0023 article-title: Actively-targeted LTVSPWY peptide-modified magnetic nanoparticles for tumor imaging publication-title: Int J Nanomedicine – volume: 107 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0010 article-title: Tailor-made PEG coated iron oxide nanoparticles as contrast agents for long lasting magnetic resonance molecular imaging of solid cancers publication-title: Mater Sci Eng C Mater Biol Appl doi: 10.1016/j.msec.2019.110262 – volume: 23 start-page: 3638 issue: 14 year: 2017 ident: 10.1016/j.ebiom.2022.104040_bib0042 article-title: Correlation between ferumoxytol uptake in tumor lesions by MRI and response to nanoliposomal irinotecan in patients with advanced solid tumors: a pilot study publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-16-1990 – volume: 316 start-page: 315 issue: 3 year: 2004 ident: 10.1016/j.ebiom.2022.104040_bib0021 article-title: Hepatic cellular distribution and degradation of iron oxide nanoparticles following single intravenous injection in rats: implications for magnetic resonance imaging publication-title: Cell Tissue Res doi: 10.1007/s00441-004-0884-8 – volume: 7 start-page: 3503 year: 2012 ident: 10.1016/j.ebiom.2022.104040_bib0024 article-title: Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells publication-title: Int J Nanomedicine – volume: 34 issue: 3 year: 2022 ident: 10.1016/j.ebiom.2022.104040_bib0030 article-title: An enzyme-activatable aggregation-induced-emission probe: intraoperative pathological fluorescent diagnosis of pancreatic cancer via specific cathepsin E publication-title: Adv Mater doi: 10.1002/adma.202107444 – volume: 18 start-page: 558 issue: 9 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0039 article-title: Intratumoural administration and tumour tissue targeting of cancer immunotherapies publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-021-00507-y – volume: 24 start-page: 3870 issue: 28 year: 2012 ident: 10.1016/j.ebiom.2022.104040_bib0015 article-title: X-space MPI: magnetic nanoparticles for safe medical imaging publication-title: Adv Mater doi: 10.1002/adma.201200221 – volume: 21 start-page: 2730 issue: 7 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0017 article-title: Mixed metal metal-organic frameworks derived carbon supporting ZnFe2O4/C for high-performance magnetic particle imaging publication-title: Nano Lett doi: 10.1021/acs.nanolett.0c04455 – volume: 26 start-page: 2062 issue: 10 year: 2015 ident: 10.1016/j.ebiom.2022.104040_bib0028 article-title: Novel radiotracer for ImmunoPET imaging of PD-1 checkpoint expression on tumor infiltrating lymphocytes publication-title: Bioconjug Chem doi: 10.1021/acs.bioconjchem.5b00318 – volume: 7 start-page: 2833 year: 2012 ident: 10.1016/j.ebiom.2022.104040_bib0022 article-title: In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles publication-title: Int J Nanomedicine – volume: 14 start-page: 3306 issue: 9 year: 2022 ident: 10.1016/j.ebiom.2022.104040_bib0016 article-title: Recent development of a magneto-optical nanoplatform for multimodality imaging of pancreatic ductal adenocarcinoma publication-title: Nanoscale doi: 10.1039/D1NR08394E – volume: 10 start-page: 391 year: 2008 ident: 10.1016/j.ebiom.2022.104040_bib0009 article-title: Chemical exchange saturation transfer contrast agents for magnetic resonance imaging publication-title: Annu Rev Biomed Eng doi: 10.1146/annurev.bioeng.9.060906.151929 – volume: 19 start-page: 223 issue: 1 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0032 article-title: Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy publication-title: J Nanobiotechnol doi: 10.1186/s12951-021-00963-9 – volume: 193 start-page: 314 issue: 2 year: 2009 ident: 10.1016/j.ebiom.2022.104040_bib0019 article-title: In vivo MRI cell tracking: clinical studies publication-title: AJR Am J Roentgenol doi: 10.2214/AJR.09.3107 – volume: 13 start-page: 7750 issue: 7 year: 2019 ident: 10.1016/j.ebiom.2022.104040_bib0008 article-title: A magneto-optical nanoplatform for multimodality imaging of tumors in mice publication-title: ACS Nano doi: 10.1021/acsnano.9b01436 – volume: 51 start-page: 1659 issue: 6 year: 2020 ident: 10.1016/j.ebiom.2022.104040_bib0013 article-title: Magnetic particle imaging: current applications in biomedical research publication-title: J Magn Reson Imaging doi: 10.1002/jmri.26875 – volume: 17 start-page: 302 issue: 2 year: 2011 ident: 10.1016/j.ebiom.2022.104040_bib0026 article-title: Plectin-1 as a novel biomarker for pancreatic cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-10-0999 – volume: 48 start-page: 332 issue: 2 year: 2021 ident: 10.1016/j.ebiom.2022.104040_bib0037 article-title: Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery publication-title: Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-020-04970-0 – volume: 2017 year: 2017 ident: 10.1016/j.ebiom.2022.104040_bib0029 article-title: Effects of depilation-induced skin pigmentation and diet-induced fluorescence on in vivo fluorescence imaging publication-title: Contrast Media Mol Imaging doi: 10.1155/2017/7659242 – volume: 17 start-page: 1648 issue: 3 year: 2017 ident: 10.1016/j.ebiom.2022.104040_bib0012 article-title: Magnetic particle imaging: a novel in vivo imaging platform for cancer detection publication-title: Nano Lett doi: 10.1021/acs.nanolett.6b04865 |
| SSID | ssj0001542358 |
| Score | 2.390784 |
| Snippet | Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle imaging (MPI)... SummaryBackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic... Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy worldwide, and the precise detection is challenging currently. Magnetic particle... |
| SourceID | doaj pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 104040 |
| SubjectTerms | Advanced Basic Science Animals Antineoplastic Agents - therapeutic use Carcinoma, Pancreatic Ductal - diagnostic imaging Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Fluorescence molecular imaging (FMI) Humans Internal Medicine Magnetic particle imaging (MPI) Magnetic resonance imaging (MRI) Magnetic Resonance Imaging - methods Mice Multimodal Imaging Pancreatic ductal adenocarcinoma (PDAC) Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Plectin Superparamagnetic iron oxide nanoparticles (SPIONs) |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9UwFA4yILgR39bHEMGlxTRNm3bpDA6DoC50YHYhaVKt2LRMOwt_i3_Wc5K23DvKzMbVhbZp6Ml3z_lOch6EvAabC05Cy1LwZ3UqTM1SYyVPtWa2KrQUOkQTfvxUnp6JD-fF-U6rL4wJi-WBo-DeGl4xBxzZtrYQgmkjWG4FN9YWjpeyQe0LNm_HmYr5wQJzQENnuYKneV2KteRQCO5ymNwO3iHneMjJcOtjxyyF6v171ulv9nk1iHLHKp3cI3cXOknfxc-4T245_4Dcjg0mfz0kvz-PYa-a9vqbx3RFGgII-8EG-k27PjQpokNLR9y_7zz4ejE43Nntrsb0KwrslgJbpCPWw5gctW4OYVweR-PpzzAPI8wA6iUy0YZiLVmYXINuA5N50XR-6DXtPO1BPT0iZyfvvx6fpks7hrQpcz6nmc3LunVZK0HArhINN6UrqqxkNZc1q42sNGskKCyTG3DjHBO5a3MgEI3JsHLcY3LgB--eEmqBhrAW3mbaCtFQ4S-AJpOmaAzjCeHraqhmqVWOLTN-qjUo7YcKS6hwCVVcwoS82QaNsVTH9Y8f4TJvj2Kd7XAB0KcW9Kmb0JcQsYJEramsoHzhRd31c8t_DXPTokAmlamJK6a-IHwRvRyDaUCGCSm3kQtHitzn5ilfrRhWoEHwWEh7N1xOCikaq2rQ3Ql5EjG9CQXYKC84g2nlHtr3pLZ_x3ffQ5XymknwLapn_0PMz8kd_JQYoveCHMwXl-4lkMHZHIb__R_hDFyb priority: 102 providerName: Directory of Open Access Journals |
| Title | Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2352396422002213 https://www.clinicalkey.es/playcontent/1-s2.0-S2352396422002213 https://dx.doi.org/10.1016/j.ebiom.2022.104040 https://www.ncbi.nlm.nih.gov/pubmed/35525203 https://www.proquest.com/docview/2661089257 https://pubmed.ncbi.nlm.nih.gov/PMC9079778 https://doaj.org/article/b280e428dfd5440ab403d42bdd5e267c |
| Volume | 80 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9UwEA7riuCLeLdelgg-WknTtGkfRFRcFmH1QQ_sW0iadK1sL552wf0t_lln0otWD-uLnIcDp02GM5nMfJPMhZBnYHPBSShZCP6sDoXJWWis5KHWzGaJlkL7aMLjD-nRRrw_SU72yNwVdWJgv9O1w35Sm-3Zi-_fLl7Bhn_5K1bLYa46OHuc450lfK6Qq2CaJLY0OJ7w_pg2LDA11DecS3gY56mYKxHtnmdlrXxR_5XR-huU_hlb-ZuxOrxJbkwok74exeIW2XPNbXJt7Dt5cYf8-Nj5I2xa69MGsxipjyusW-tROa1q37uItiXt8Fi_asAFHGPGnV2easzKogB6KYBI2mGZjN5R6wYf3dXgaLwUaoe2AwqgdUaAWlAsMQvENag8sKTbomraWtOqoTVorbtkc_ju89ujcOrSEBZpzIcwsnGaly4qJTDYZaLgJnVJFqUs5zJnuZGZZoUEPWZiA96dYyJ2ZQy4ojARFpS7R_abtnEPCLWATlgJs5kyQyHJ8BtkKZImKQzjAeHzaqhiKmGOnTTO1Byr9lX5JVS4hGpcwoA8XwZ1YwWPy19_g8u8vIrlt_0P7fZUTbtZGZ4xB46bLW0iBNNGsNgKbqxNHE9lERAxC4maM1xBJ8NE1eW05a5hrp-3hYpUzxVTn1B8UXo5xtgADwOSLiMn6DRCon-TfDrLsALFgrdFunHtea8QubEsB5UekPujTC9MAZDKE86ArFxJ-4pr6ydN9cUXL8-ZBJcje_g_2PyIXMe_MkbuPSb7w_bcPQGMOJgDf7Zy4Hf_TwBsZjA |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optical+magnetic+multimodality+imaging+of+plectin-1-targeted+imaging+agent+for+the+precise+detection+of+orthotopic+pancreatic+ductal+adenocarcinoma+in+mice&rft.jtitle=EBioMedicine&rft.au=Wenjia+Zhang&rft.au=Xiaolong+Liang&rft.au=Liang+Zhu&rft.au=Xinyu+Zhang&rft.date=2022-06-01&rft.pub=Elsevier&rft.issn=2352-3964&rft.eissn=2352-3964&rft.volume=80&rft.spage=104040&rft_id=info:doi/10.1016%2Fj.ebiom.2022.104040&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b280e428dfd5440ab403d42bdd5e267c |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F23523964%2FS2352396422X00066%2Fcov150h.gif |