An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy - Niu, Gang; Jin, Zhuang; Zhang, Chong; He, Dan; Gao, Xueqin; Zou, Chenming; Zhang, Wei; Ding, Jiahui; Das, Bhudev C.; Severinov, Konstantin; Hitzeroth, Inga Isabel; Debata, Priya Ranjan; et al. (EBioMedicine, 2020)
Keywords: Administration, Intravaginal; Advanced Basic Science; Animals; Bentonite - chemistry; Cells, Cultured; Cervix Uteri - chemistry; Cervix Uteri - cytology; CRISPR-Cas Systems; CRISPR/Cas9; Endogenous Retroviruses - drug effects; Endogenous Retroviruses - genetics; Female; Gene Dosage - drug effects; Gene Editing; Gene therapy; Genetic Therapy; Internal Medicine; Local delivery; Mice; Models, Animal; Nanoparticles; Plasmids - administration & dosage; Plasmids - genetics; Poly (β-amino ester); Polymers - chemistry; Research paper; RNA, Guide, CRISPR-Cas Systems - administration & dosage; Silicates - chemistry; Swine; Vaginal Creams, Foams, and Jellies; Vaginal gel; Local delivery; Poly (β-amino ester); Vaginal gel; CRISPR/Cas9; Gene therapy