Detection of enteroviruses in the intestine of type 1 diabetic patients

• Published in: Clinical and experimental immunology Vol. 151; no. 1; pp. 71 - 75
• Main Authors: Oikarinen, M., Tauriainen, S., Honkanen, T., Oikarinen, S., Vuori, K., Kaukinen, K., Rantala, I., Mäki, M., Hyöty, H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2008; Blackwell; Blackwell Science Inc
• Subjects: Adolescent; Adult; analysis; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Case-Control Studies; Chi-Square Distribution; complications; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 1 - virology; Diabetes. Impaired glucose tolerance; DNA, Viral; DNA, Viral - analysis; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enterovirus; Enterovirus - genetics; Enterovirus - isolation & purification; Enterovirus Infections; Enterovirus Infections - complications; enteroviruses; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; genetics; Humans; Immunohistochemistry; In Situ Hybridization; insulin-dependent diabetes mellitus; Intestinal Mucosa; Intestinal Mucosa - virology; Intestine, Small; isolation & purification; Male; Medical sciences; Middle Aged; Paraffin Embedding; Reverse Transcriptase Polymerase Chain Reaction; small intestine; Translational Studies; type 1 diabetes; virology; Endocrinopathy; Human; Immunohistochemistry; Immunopathology; Molecular hybridization; Digestive system; Autoimmune disease; Biochemistry; Small intestine; Anatomic pathology; enteroviruses; Type 1 diabetes; Genetics; Molecular biology; Detection; in situ hybridization

Summary Enterovirus infections have been diagnosed more frequently in type 1 diabetic patients than in the healthy population, and enteroviruses have also been found in the pancreas of diabetic patients. Primary replication of the virus occurs in the gut, but there are no previous studies evaluating...