Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes - Zheng, Xiaowei; Narayanan, Sampath; Xu, Cheng; Eliasson Angelstig, Sofie; Grünler, Jacob; Zhao, Allan; Di Toro, Alessandro; Bernardi, Luciano; Mazzone, Massimiliano; Carmeliet, Peter; Del Sole, Marianna; Solaini, Giancarlo; et al. (eLife, 2022)
Keywords: Adult; Analysis; Animal models; Animals; Apoptosis; Cell Biology; Cell culture; Cell Line; Dextrose; Diabetes; Diabetes Complications; Diabetes mellitus (insulin dependent); Diabetes Mellitus - blood; Diabetes Mellitus - genetics; diabetic complications; Female; Glucose; Glycerol; Health aspects; Human; Humans; Hydroxylase; Hyperglycemia; Hyperglycemia - genetics; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1 - antagonists & inhibitors; Hypoxia-Inducible Factor 1 - genetics; Kidney - pathology; Kidneys; Male; Medicine; Mice; Mitochondria; Mitochondria - metabolism; Mouse; Plasmids; Pyruvic acid; Reactive oxygen species; Reactive Oxygen Species - blood; Reactive Oxygen Species - metabolism; Signal Transduction; Spectrum analysis; Therapeutic targets; Transcription factors; Type 1 diabetes; Young Adult; Canada; United States--US; diabetic complications; hypoxia; mouse; cell biology; mitochondria; hypoxia-inducible factor-1; reactive oxygen species; medicine; diabetes; human