Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice
Aims Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effec...
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| Published in | Neuropsychopharmacology reports Vol. 40; no. 1; pp. 73 - 84 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.03.2020
John Wiley and Sons Inc Wiley |
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| Online Access | Get full text |
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| Abstract | Aims
Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety‐ and depression‐related behaviors, and plasma corticosterone levels in mice.
Methods
Adult male BALB/cAJcl mice were restrained by placing them in either a well‐ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test.
Results
Exposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film‐restraint–stressed mice had significantly lower body weights than tube‐restraint–stressed mice. Film‐restraint–stressed mice exhibited significantly higher or lower immobility during forced swim than tube‐restraint–stressed mice, depending on the test time. Additionally, the stress‐induced increase in plasma corticosterone levels was found to be higher in film‐restraint–stressed mice than in tube‐restraint–stressed mice.
Conclusion
Our results indicate that film‐restraint stress has more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress‐induced neuropsychiatric disorders.
This study investigated the effects of stress exposure via two types of restraint apparatuses, a well‐ventilated plastic conical tube and a tapered plastic film envelope, on body weights, behaviors, and plasma corticosterone levels in male BALB/cAJcl mice. Film‐restraint stress had more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress, which may help guide which restraint stress procedures to use in generating animal models of stress‐induced disorders. |
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| AbstractList | Restraint stress is one of the most widely used experimental methods for generating rodent models of stress-induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety- and depression-related behaviors, and plasma corticosterone levels in mice.AIMSRestraint stress is one of the most widely used experimental methods for generating rodent models of stress-induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety- and depression-related behaviors, and plasma corticosterone levels in mice.Adult male BALB/cAJcl mice were restrained by placing them in either a well-ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test.METHODSAdult male BALB/cAJcl mice were restrained by placing them in either a well-ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test.Exposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film-restraint-stressed mice had significantly lower body weights than tube-restraint-stressed mice. Film-restraint-stressed mice exhibited significantly higher or lower immobility during forced swim than tube-restraint-stressed mice, depending on the test time. Additionally, the stress-induced increase in plasma corticosterone levels was found to be higher in film-restraint-stressed mice than in tube-restraint-stressed mice.RESULTSExposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film-restraint-stressed mice had significantly lower body weights than tube-restraint-stressed mice. Film-restraint-stressed mice exhibited significantly higher or lower immobility during forced swim than tube-restraint-stressed mice, depending on the test time. Additionally, the stress-induced increase in plasma corticosterone levels was found to be higher in film-restraint-stressed mice than in tube-restraint-stressed mice.Our results indicate that film-restraint stress has more pronounced effects on body weight, depression-related behavior, and corticosterone response than tube-restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress-induced neuropsychiatric disorders.CONCLUSIONOur results indicate that film-restraint stress has more pronounced effects on body weight, depression-related behavior, and corticosterone response than tube-restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress-induced neuropsychiatric disorders. Abstract Aims Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety‐ and depression‐related behaviors, and plasma corticosterone levels in mice. Methods Adult male BALB/cAJcl mice were restrained by placing them in either a well‐ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test. Results Exposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film‐restraint–stressed mice had significantly lower body weights than tube‐restraint–stressed mice. Film‐restraint–stressed mice exhibited significantly higher or lower immobility during forced swim than tube‐restraint–stressed mice, depending on the test time. Additionally, the stress‐induced increase in plasma corticosterone levels was found to be higher in film‐restraint–stressed mice than in tube‐restraint–stressed mice. Conclusion Our results indicate that film‐restraint stress has more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress‐induced neuropsychiatric disorders. This study investigated the effects of stress exposure via two types of restraint apparatuses, a well‐ventilated plastic conical tube and a tapered plastic film envelope, on body weights, behaviors, and plasma corticosterone levels in male BALB/cAJcl mice. Film‐restraint stress had more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress, which may help guide which restraint stress procedures to use in generating animal models of stress‐induced disorders. Restraint stress is one of the most widely used experimental methods for generating rodent models of stress-induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety- and depression-related behaviors, and plasma corticosterone levels in mice. Adult male BALB/cAJcl mice were restrained by placing them in either a well-ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test. Exposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film-restraint-stressed mice had significantly lower body weights than tube-restraint-stressed mice. Film-restraint-stressed mice exhibited significantly higher or lower immobility during forced swim than tube-restraint-stressed mice, depending on the test time. Additionally, the stress-induced increase in plasma corticosterone levels was found to be higher in film-restraint-stressed mice than in tube-restraint-stressed mice. Our results indicate that film-restraint stress has more pronounced effects on body weight, depression-related behavior, and corticosterone response than tube-restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress-induced neuropsychiatric disorders. Aims Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety‐ and depression‐related behaviors, and plasma corticosterone levels in mice. Methods Adult male BALB/cAJcl mice were restrained by placing them in either a well‐ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test. Results Exposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film‐restraint–stressed mice had significantly lower body weights than tube‐restraint–stressed mice. Film‐restraint–stressed mice exhibited significantly higher or lower immobility during forced swim than tube‐restraint–stressed mice, depending on the test time. Additionally, the stress‐induced increase in plasma corticosterone levels was found to be higher in film‐restraint–stressed mice than in tube‐restraint–stressed mice. Conclusion Our results indicate that film‐restraint stress has more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress‐induced neuropsychiatric disorders. This study investigated the effects of stress exposure via two types of restraint apparatuses, a well‐ventilated plastic conical tube and a tapered plastic film envelope, on body weights, behaviors, and plasma corticosterone levels in male BALB/cAJcl mice. Film‐restraint stress had more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress, which may help guide which restraint stress procedures to use in generating animal models of stress‐induced disorders. AimsRestraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as depression and anxiety. Although various types of restraint apparatuses have been used to expose animals to stress, the magnitudes of the effects of stress exposure via different types of restraint apparatuses on physiology and behavior have not been compared in the same environment. Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety‐ and depression‐related behaviors, and plasma corticosterone levels in mice.MethodsAdult male BALB/cAJcl mice were restrained by placing them in either a well‐ventilated plastic conical tube or a tapered plastic film envelope for 6 hours per day for 10 or 21 consecutive days. Mice were weighed during and after the stress period and were subjected to a battery of behavioral tests, including light/dark transition, open field, elevated plus maze, Porsolt forced swim, tail suspension, and sucrose preference tests, starting on the day after the last stress session. Plasma corticosterone levels were measured in another cohort of mice on the 1st and the 21st stress sessions and after the Porsolt forced swim test.ResultsExposure to repeated stress via the two above mentioned types of restraint apparatuses caused body weight loss, heightened locomotor activity, altered immobility during forced swim, and increased plasma corticosterone levels, and some of these results differed between the restraint stress protocols. Film‐restraint–stressed mice had significantly lower body weights than tube‐restraint–stressed mice. Film‐restraint–stressed mice exhibited significantly higher or lower immobility during forced swim than tube‐restraint–stressed mice, depending on the test time. Additionally, the stress‐induced increase in plasma corticosterone levels was found to be higher in film‐restraint–stressed mice than in tube‐restraint–stressed mice.ConclusionOur results indicate that film‐restraint stress has more pronounced effects on body weight, depression‐related behavior, and corticosterone response than tube‐restraint stress in mice. These findings may help guide which restraint stress procedures to use, depending on the objectives of a given study, in generating animal models of stress‐induced neuropsychiatric disorders. |
| Author | Shoji, Hirotaka Miyakawa, Tsuyoshi |
| AuthorAffiliation | 1 Division of Systems Medical Science Institute for Comprehensive Medical Science Fujita Health University Toyoake Japan |
| AuthorAffiliation_xml | – name: 1 Division of Systems Medical Science Institute for Comprehensive Medical Science Fujita Health University Toyoake Japan |
| Author_xml | – sequence: 1 givenname: Hirotaka orcidid: 0000-0003-4843-6949 surname: Shoji fullname: Shoji, Hirotaka organization: Fujita Health University – sequence: 2 givenname: Tsuyoshi orcidid: 0000-0003-0137-8200 surname: Miyakawa fullname: Miyakawa, Tsuyoshi email: miyakawa@fujita-hu.ac.jp organization: Fujita Health University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31872573$$D View this record in MEDLINE/PubMed |
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| Copyright | 2019 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology. 2019 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology. 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| References | 2012; 60 2017; 6 2003; 117 2010; 58 2011; 216 1997; 81 1991; 12 2004; 29 1986; 10 1977; 229 2000; 72 2016; 167 2007; 90 2012; 39 1985; 85 2006; 1 2014; 85 2006; 138 2013; 8 1977; 266 2001; 125 2003; 78 2009; 33 2016; 6 2000; 886 1980; 13 2005; 6 1994; 18 1978; 47 2005; 16 2012; 45 2014; 268 2006; 147 e_1_2_10_23_1 e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_22_1 e_1_2_10_20_1 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_6_1 Takao K (e_1_2_10_13_1) 2006; 1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_8_1 e_1_2_10_7_1 e_1_2_10_12_1 e_1_2_10_9_1 e_1_2_10_34_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_11_1 e_1_2_10_32_1 e_1_2_10_31_1 e_1_2_10_30_1 Shoji H (e_1_2_10_16_1) 2014; 85 Shoji H (e_1_2_10_15_1) 2012; 60 Porsolt RD (e_1_2_10_14_1) 1977; 229 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 e_1_2_10_25_1 e_1_2_10_26_1 |
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Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as... Restraint stress is one of the most widely used experimental methods for generating rodent models of stress-induced neuropsychiatric disorders, such as... AimsRestraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders, such as... This study investigated the effects of stress exposure via two types of restraint apparatuses, a well‐ventilated plastic conical tube and a tapered plastic... Abstract Aims Restraint stress is one of the most widely used experimental methods for generating rodent models of stress‐induced neuropsychiatric disorders,... |
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| SubjectTerms | BALB/cA Behavior depression inbred strain Light mouse model Original Physiology repeated restraint stress Stress Sucrose |
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| Title | Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice |
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