769-P: Effect of Food on the Pharmacokinetics, Safety, and Tolerability of Orforglipron (LY3502970), an Oral, Nonpeptide GLP-1 Receptor Agonist

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: MA, XIAOSU, LIU, RONG, PRATT, EDWARD J., BENSON, CHARLES, BHATTACHAR, SHOBHA N.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Agonists; Appetite loss; Food; GLP-1 receptor agonists; Glucagon; Glucagon-like peptide 1; Peptides; Pharmacokinetics; Safety; Statistical analysis; Vomiting

Orforglipron [OFG (LY3502970)] is an oral, non-peptide glucagon-like peptide-1 receptor agonist (GLP-1 RA). This reports the results of 2 studies that assessed PK, safety, and tolerability of OFG in healthy subjects, fasted and fed state, after single and repeated doses. Studies A and B were phase 1...