大鼠衰老过程中海马血管内皮生长因子及微血管密度的表达特点

R741.02; 目的:探讨大鼠衰老过程中海马血管内皮生长因子(VEGF)及微血管密度(MVD)的表达特点.方法:对3、18、24、30月龄(各10只)大鼠脑组织石蜡切片进行免疫组织化学染色,定量分析海马VEGF的表达规律和微血管变化.结果:①VEGF在各组大鼠海马组织中均有表达,主要表达于锥体细胞胞浆内,随增龄VEGF阳性细胞个数逐渐减少(P＜0.05);②MVD在各组大鼠均可见,随月龄增加MVD逐渐减少(P＜0.05).结论:VEGF及MVD随增龄在海马组织中表达减少,且两者的改变相一致,提示增加衰老大鼠脑组织内VEGF含量和改善脑组织血液循环,对预防和治疗老年脑血管病,血管性痴呆有重要意...

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Published in浙江大学学报（医学版） Vol. 39; no. 4; pp. 404 - 408
Main Authors 吴海琴, 任蓓, 沙娟娟, 王虎清, 张桂莲, 李明
Format Journal Article
LanguageChinese
Published 西安交通大学医学院,第二附属医院神经内科,陕西,西安,710004%西安交通大学医学院,人体解剖学与组织胚胎学系,陕西,西安,710061 2010
Subjects
衰老
血管
大鼠
海马
微血管密度
脑/代谢
痴呆
血管内皮生长因子A
血管内皮生长因子
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2010.04.012

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Abstract R741.02; 目的:探讨大鼠衰老过程中海马血管内皮生长因子(VEGF)及微血管密度(MVD)的表达特点.方法:对3、18、24、30月龄(各10只)大鼠脑组织石蜡切片进行免疫组织化学染色,定量分析海马VEGF的表达规律和微血管变化.结果:①VEGF在各组大鼠海马组织中均有表达,主要表达于锥体细胞胞浆内,随增龄VEGF阳性细胞个数逐渐减少(P＜0.05);②MVD在各组大鼠均可见,随月龄增加MVD逐渐减少(P＜0.05).结论:VEGF及MVD随增龄在海马组织中表达减少,且两者的改变相一致,提示增加衰老大鼠脑组织内VEGF含量和改善脑组织血液循环,对预防和治疗老年脑血管病,血管性痴呆有重要意义.
AbstractList R741.02; 目的:探讨大鼠衰老过程中海马血管内皮生长因子(VEGF)及微血管密度(MVD)的表达特点.方法:对3、18、24、30月龄(各10只)大鼠脑组织石蜡切片进行免疫组织化学染色,定量分析海马VEGF的表达规律和微血管变化.结果:①VEGF在各组大鼠海马组织中均有表达,主要表达于锥体细胞胞浆内,随增龄VEGF阳性细胞个数逐渐减少(P＜0.05);②MVD在各组大鼠均可见,随月龄增加MVD逐渐减少(P＜0.05).结论:VEGF及MVD随增龄在海马组织中表达减少,且两者的改变相一致,提示增加衰老大鼠脑组织内VEGF含量和改善脑组织血液循环,对预防和治疗老年脑血管病,血管性痴呆有重要意义.
Author 王虎清
吴海琴
任蓓
张桂莲
沙娟娟
李明
AuthorAffiliation 西安交通大学医学院,第二附属医院神经内科,陕西,西安,710004%西安交通大学医学院,人体解剖学与组织胚胎学系,陕西,西安,710061
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SHA Juan-juan
LI Ming
WANG Hu-qing
ZHANG Gui-lian
WU Hai-qin
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Keywords 衰老
血管
大鼠
海马
微血管密度
脑/代谢
痴呆
血管内皮生长因子A
血管内皮生长因子
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