Ketone production by ketogenic diet and by intermittent fasting has different effects on the gut microbiota and disease progression in an Alzheimer’s disease rat model

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 67; no. 2; pp. 188 - 198
• Main Authors: Park, Sunmin, Zhang, Ting, Wu, Xuangao, Qiu, Jing Yi
• Format: Journal Article
• Language: English
• Published: Gifu SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.01.2020; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: Alzheimer's disease; Amyloid; amyloid-β; Carbohydrates; Cognitive ability; Dementia disorders; Diet; Digestive system; Dysbacteriosis; Fasting; Glucose; Glucose metabolism; Glucose tolerance; gut microbiome; Gut microbiota; High carbohydrate diet; High fat diet; Hippocampus; Inflammation; Insulin; insulin signaling; Intestinal microflora; Intolerance; Ketogenesis; ketone; Ketones; Low carbohydrate diet; Memory; Microbiomes; Microbiota; Neurodegenerative diseases; Original; Starch

The benefits of ketone production regimens remain controversial. Here, we hypothesized that the ketone-producing regimens modulated cognitive impairment, glucose metabolism, and inflammation while altering the gut microbiome. The hypothesis and the mechanism were explored in amyloid-β infused rats....