Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti

• Published in: BMC biology Vol. 20; no. 1; pp. 43 - 20
• Main Authors: Inaba, Kazue, Ebihara, Kana, Senda, Miki, Yoshino, Ryunosuke, Sakuma, Chisako, Koiwai, Kotaro, Takaya, Daisuke, Watanabe, Chiduru, Watanabe, Akira, Kawashima, Yusuke, Fukuzawa, Kaori, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Uemura, Nozomi, Kasai, Shinji, Kanuka, Hirotaka, Nishimura, Takashi, Watanabe, Kodai, Inoue, Hideshi, Fujikawa, Yuuta, Honma, Teruki, Hirokawa, Takatsugu, Senda, Toshiya, Niwa, Ryusuke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.02.2022; BioMed Central; BMC
• Subjects: Aedes; Aedes aegypti; Analysis; Animals; Binding sites; Biosynthesis; Chemical compounds; Control; Crystal structure; Crystals; Daidzein; Dengue fever; Developmental stages; Ecdysone; Ecdysteroid; Enzymes; Flavonoid; Flavonoids; Glutathione; Glutathione S-transferase; Glutathione transferase; Glutathione Transferase - metabolism; Health aspects; Humans; Hydrogen bonds; Infectious diseases; Inhibitors; Insect control; Insect growth regulator; Insecticides; Insects; Larva; Larval development; Larvicides; Methods; Mode of action; Molecular dynamics; Mosquito Control; Mosquitoes; Mutation; Phenolic compounds; Phenols; Protein structure; Proteins; Reagents; Structure; Tropical diseases; Vector-borne diseases; Viruses; Yellow fever; Japan; Ecdysteroid; Noppera-bo; Insecticide; Mosquito; Aedes aegypti; Ecdysone; Insect growth regulator; Glutathione S-transferase; Flavonoid

Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of selective and safe reagents for mosquito control. Flavonoids, a group of chemical substances with variable phenolic structures, such as daidzein,...