The Ron receptor promotes prostate tumor growth in the TRAMP mouse model

• Published in: Oncogene Vol. 30; no. 50; pp. 4990 - 4998
• Main Authors: Thobe, M N, Gray, J K, Gurusamy, D, Paluch, A M, Wagh, P K, Pathrose, P, Lentsch, A B, Waltz, S E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.12.2011; Nature Publishing Group
• Subjects: 692/420/755; 692/699/67/589/466; Angiogenesis; Animal models; Animals; Apoptosis; Biological and medical sciences; Care and treatment; Cell Biology; Cell growth; Cell physiology; Cell Proliferation; Cell receptors; Cell structures and functions; Cell survival; Cell Survival - genetics; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chemokine CXCL2 - genetics; Chemokine CXCL2 - metabolism; Chemokines; Crosses, Genetic; Data processing; Diagnosis; Disease Models, Animal; Female; Fundamental and applied biological sciences. Psychology; Genetic engineering; Growth factors; Health aspects; Human Genetics; Humans; Internal Medicine; Kinases; Male; Medical sciences; Medicine; Medicine & Public Health; Mice; Mice, Knockout; Miscellaneous; Molecular and cellular biology; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Nephrology. Urinary tract diseases; NF-kappa B - genetics; NF-kappa B - metabolism; Oncology; original-article; Physiological aspects; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Protein-tyrosine kinase; Protein-tyrosine kinase receptors; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Receptors, Tumor Necrosis Factor, Member 25 - genetics; Receptors, Tumor Necrosis Factor, Member 25 - metabolism; Signal transduction; Transcription factors; Tumor cell lines; Tumor cells; Tumorigenesis; Tumors; Tumors of the urinary system; Tyrosine; Urinary tract. Prostate gland; Vascular endothelial growth factor; Vascularization; United States; United States > US; prostate cancer; receptor tyrosine kinase; MST1R; hepatoctye growth factor-like protein; Ron receptor; Animal model; Prostate tumor; Urinary system disease; Prostate disease; Enzyme; Transferases; Rodentia; Malignant tumor; Carcinogenesis; Protein; Vertebrata; Mammalia; Mouse; Male genital diseases; Prostate cancer; Protein-tyrosine kinase; Cancer; Growth factor; Biological receptor

The Ron receptor tyrosine kinase (TK) is overexpressed in many cancers, including prostate cancer. To examine the significance of Ron in prostate cancer in vivo , we utilized a genetically engineered mouse model, referred to as TRAMP mice, that is predisposed to develop prostate tumors. In this mode...