Microglia play an important role in PRV infection-induced immune responses of the central nervous system

• Published in: Virology journal Vol. 20; no. 1; p. 151
• Main Authors: Sun, Xiuxiu, Jin, Xinxin, Liu, Xi, Wang, Lumeng, Li, Li, Yang, Junjie, Feng, Helong, Lin, Zhengdan, Zhan, Cunlin, Zhang, Wanpo, Gu, Changqin, Hu, Xueying, Liu, Xiaoli, Cheng, Guofu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.07.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Aujeszky's disease; Blood vessels; Blood-brain barrier; Brain; Care and treatment; Central nervous system; Chemokines; Cytokines; Diagnosis; Encephalitis; Herpesvirus 1, Suid; Hogs; Immune response; Immunity; Infections; Infectivity; Infiltration; Inflammation; Ligands; Lymphocytes; Medical research; Medicine, Experimental; Mice; Microglia; Nervous system; neuroglia; Neurons; pathogenicity; Phagocytes; Phagocytosis; Proteins; Pseudorabies; Pseudorabies virus; Replication; Suid alphaherpesvirus 1; Swine; Tumor necrosis factor-TNF; Viral infections; virus replication; China; Inflammation; Pseudorabies virus; Central nervous system; Microglia
• ISSN: 1743-422X; 1743-422X
• DOI: 10.1186/s12985-023-02118-8

Pseudorabies virus (PRV) can infect multiple hosts and lead to fatal encephalitis. There is a significant increase in the number of microglia in the brain of animals infected with PRV. However, whether and how microglia contribute to central nervous system damage in PRV infection remain unknown. In...