Molecular epidemiology and outcome of carbapenem-resistant Enterobacterales in Saudi Arabia

• Published in: BMC infectious diseases Vol. 22; no. 1; pp. 542 - 8
• Main Authors: Alraddadi, Basem M., Heaphy, Emily L. G., Aljishi, Yamama, Ahmed, Waleed, Eljaaly, Khalid, Al-Turkistani, Hanan H., Alshukairi, Abeer N., Qutub, Mohammed O., Alodini, Kholoud, Alosaimi, Roaa, Hassan, Waseem, Attalah, Dalya, Alswaiel, Rakan, Saeedi, Mohammed F., Al-Hamzi, Mohammed A., Hefni, Lama K., Almaghrabi, Reem S., Anani, Mushira, Althaqafi, Abdulhakeem
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.06.2022; BioMed Central; BMC
• Subjects: Age; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteremia; Bacteremia - drug therapy; Bacteremia - epidemiology; Bacteria; Carbapenem-resistant Enterobacterales (CRE); Carbapenems - pharmacology; Carbapenems - therapeutic use; Comorbidity; Continuity (mathematics); Diabetes; Diabetes mellitus; Drug resistance in microorganisms; Drug therapy; E coli; Enterobacterales; Enterobacteriaceae Infections - drug therapy; Enterobacteriaceae Infections - epidemiology; Epidemiology; Escherichia coli; Female; Gram-negative bacterial infections; Healthcare-Associated Pneumonia - drug therapy; Hospitals; Humans; Infections; Kidneys; Klebsiella; Male; Middle Aged; Molecular Epidemiology; Mortality; Multidrug resistant gram negative bacteria; Nosocomial infection; OXA-48; Patient outcomes; Patients; Pneumonia; Prospective Studies; Saudi Arabia; Saudi Arabia - epidemiology; Statistics; Urinary tract; Saudi Arabia; Saudi Arabia; Multidrug resistant gram negative bacteria; Carbapenem-resistant Enterobacterales (CRE); OXA-48

The burden of carbapenem resistance is not well studied in the Middle East. We aimed to describe the molecular epidemiology and outcome of carbapenem-resistant Enterobacterales (CRE) infections from several Saudi Arabian Centers. This is a multicenter prospective cohort study conducted over a 28-mon...