Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1–Associated Dementia

• Published in: PLoS pathogens Vol. 5; no. 4; p. e1000395
• Main Authors: Schnell, Gretja, Spudich, Serena, Harrington, Patrick, Price, Richard W., Swanstrom, Ronald
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2009; Public Library of Science (PLoS)
• Subjects: AIDS Dementia Complex - pathology; AIDS Dementia Complex - virology; Antiretroviral drugs; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Blood - virology; Brain; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; Cellular Senescence; Central nervous system; Central Nervous System - virology; Cerebrospinal Fluid - virology; Dementia; Drug therapy; Experiments; Genetic aspects; Genetic Variation; Half-Life; Health aspects; HIV; HIV (Viruses); HIV Infections - complications; HIV Infections - pathology; HIV Infections - virology; HIV-1 - genetics; Human immunodeficiency virus; Humans; Infections; Leukocytosis; Macrophages - pathology; Macrophages - virology; Neurological Disorders/Infectious Diseases of the Nervous System; Physiological aspects; Plasma; Risk factors; Studies; T cells; Virology/Immunodeficiency Viruses; United States

Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) shortly after systemic infection and can result in the subsequent development of HIV-1-associated dementia (HAD) in a subset of infected individuals. Genetically compartmentalized virus in the CNS is associated with...