SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex - Lei, Yun; Wang, Jiangong; Wang, Dan; Li, Chen; Liu, Bin; Fang, Xing; You, Jingjing; Guo, Ming; Lu, Xin-Yun (Molecular psychiatry, 2020)
Keywords: 13/51; 14/28; 38/77; 38/90; 631/378; 64/60; 692/699/476/1414; 9/74; Animals; Antidepressants; Behavioral despair; Behavioral Sciences; Biological Psychology; Brain; Depression - genetics; Depression - metabolism; Depression - pathology; Depression, Mental; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - pathology; Excitability; Excitatory Postsynaptic Potentials; Female; Forebrain; Genetic aspects; Genetic diversity; Genome-wide association studies; Genomes; Genomics; Hedonic response; Male; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Neurons; Neurons - metabolism; Neurosciences; Pharmacotherapy; Phenotypes; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Psychiatry; Pyramidal cells; Pyramidal Cells - metabolism; Rodents; Sex Characteristics; Sex differences; Sexual dimorphism; SIRT1 protein; Sirtuin 1 - deficiency; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Synaptic Transmission; Ventricle; Ventricles (cerebral); Wang Dan