Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model - Ono, Hanako; Arai, Yasuhito; Furukawa, Eisaku; Narushima, Daichi; Matsuura, Tetsuya; Nakamura, Hiromi; Shiokawa, Daisuke; Nagai, Momoko; Imai, Toshio; Mimori, Koshi; Okamoto, Koji; Hippo, Yoshitaka; et al. (BMC biology, 2021)
Keywords: Adenomatous polyposis coli; Animal models; Animals; Brain cancer; Cancer; Cancer genomics; Carcinogenesis; Cell culture; Cloning; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Deoxyribonucleic acid; Development and progression; DNA; DNA sequencing; Drug resistance; Environmental changes; Exome - genetics; Gene expression; Genes; Genetic aspects; Genetic Heterogeneity; Genetic transformation; Genomes; Heterogeneity; Intestine; Intra-tumor heterogeneity; Mesenchyme; Metastases; Metastasis; Mice; Microenvironments; Mutation; Nucleotide sequencing; Organoids; Physiological aspects; Principal components analysis; Ribonucleic acid; RNA; RNA sequencing; RNA-mediated interference; Sequence Analysis, RNA; Single-cell sequencing; Stem cells; Subpopulations; Time series; Transcription; Transcriptomes; Transplantation; Tumor cells; Tumor Microenvironment; Tumor suppressor genes; Tumorigenesis; Tumors; Japan; Single-cell sequencing; Tumorigenesis; Cancer genomics; Colorectal cancer; Intra-tumor heterogeneity