Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

• Published in: BMC genomics Vol. 21; no. 1; p. 331
• Main Authors: Babenko, Vladislav V, Podgorny, Oleg V, Manuvera, Valentin A, Kasianov, Artem S, Manolov, Alexander I, Grafskaia, Ekaterina N, Shirokov, Dmitriy A, Kurdyumov, Alexey S, Vinogradov, Dmitriy V, Nikitina, Anastasia S, Kovalchuk, Sergey I, Anikanov, Nickolay A, Butenko, Ivan O, Pobeguts, Olga V, Matyushkina, Daria S, Rakitina, Daria V, Kostryukova, Elena S, Zgoda, Victor G, Baskova, Isolda P, Trukhan, Vladimir M, Gelfand, Mikhail S, Govorun, Vadim M, Schiöth, Helgi B, Lazarev, Vassili N
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.04.2020; BioMed Central; BMC
• Subjects: Analysis; Animals; Annotations; Anticoagulants; Anticoagulants - metabolism; Blood; Datasets; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene sequencing; Genes; Genetic aspects; Genetics; Genome; Genomes; Genomics; Haematophagy; Hirudo medicinalis; Hirudo medicinalis - genetics; Hirudo medicinalis - metabolism; Homology; Leech H; Leech H. medicinalis; Leeches; Leeches - classification; Leeches - genetics; Leeches - metabolism; medicinalis; Proteins; Proteomics; Ribonucleic acid; RNA; Saliva - metabolism; Salivary Proteins and Peptides - genetics; Salivary Proteins and Peptides - metabolism; Systems biology; Russia; Leech H. medicinalis; Anticoagulants; Haematophagy; Genome; Systems biology

Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today. We annotated the Hirudo medicinalis genome and performed RNA-seq on salivary cells isolated from three closely related leech species, H. medicinalis,...