Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression

• Published in: Molecular psychiatry Vol. 16; no. 6; pp. 634 - 646
• Main Authors: Bernard, R, Kerman, I A, Thompson, R C, Jones, E G, Bunney, W E, Barchas, J D, Schatzberg, A F, Myers, R M, Akil, H, Watson, S J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2011; Nature Publishing Group
• Subjects: 631/208/191/2018; 631/378/1385/1611; 692/699/476/1414; Adolescent; Adult; Adult and adolescent clinical studies; Aged; Antidepressants; Astrocytes; Autopsy; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Brain; Brain stem; Cellular signal transduction; Cognitive ability; Depression; Depressive Disorder, Major - pathology; Development and progression; DNA microarrays; Drugs; Emotional disorders; Etiology; Female; Fibroblast growth factor receptors; Forebrain; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; Genetic aspects; Glutamate; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid - genetics; Glutamic Acid - metabolism; Growth factors; Humans; Hybridization; Innervation; Intercellular Signaling Peptides and Proteins; Lasers; Locus coeruleus; Locus Coeruleus - metabolism; Locus Coeruleus - pathology; Major depressive disorder; Male; Medical sciences; Medicine; Medicine & Public Health; Mental depression; Microdissection; Middle Aged; Models, Biological; Mood disorders; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neuroglia - metabolism; Neurosciences; Neurotransmission; Norepinephrine; Oligonucleotide Array Sequence Analysis - methods; original-article; Pharmacotherapy; Physiological aspects; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk factors; RNA, Messenger - metabolism; Signal transduction; Signal Transduction - physiology; TrkB receptors; Young Adult; United States; Germany; Ann Arbor Michigan; United States > US; California; norepinephrine; laser-capture microdissection; post mortem; microarray; human; monoamine; Mood disorder; Human; Neuroglia; Central nervous system; Postmortem; Monoamine; Depression; Catecholamine; Glutamate; Genetic determinism; Encephalon; Signal transduction; Gene; Laser; Excitatory aminoacid; Neurotransmitter; Genetics; Norepinephrine; Locus coeruleus; Growth factor; growth factor; bipolar disorder; mood disorder; locus coeruleus; glia; gene expression; major depression; glutamate

Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD). These conclusions were primarily drawn from post-mortem studies in which forebrain brain regions were examined. The locus coeruleus (LC) is t...