TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

• Published in: Oncogene Vol. 39; no. 1; pp. 64 - 78
• Main Authors: Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Regua, Angelina T., Arrigo, Austin, Anguelov, Marlyn, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.01.2020; Nature Publishing Group
• Subjects: 13/51; 631/532/71; 631/67/1347; 64/60; 96/100; Angiogenesis; Animal models; Animals; Antisense oligonucleotides; Apoptosis; Astrocytes; Astrocytes - metabolism; Astrocytes - pathology; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - radiotherapy; Brain Neoplasms - secondary; Brain tumors; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breast Neoplasms - radiotherapy; Cancer; CD44 antigen; Cell Biology; Cell Line, Tumor; Comparative analysis; Ectopic expression; ErbB-2 protein; Female; Gene Expression Regulation, Neoplastic - genetics; Genes; Genetic aspects; Glioma; Gliomas; Heterografts; Human Genetics; Humans; Hyaluronan Receptors - genetics; Immunohistochemistry; Internal Medicine; Lymph nodes; Lymphatic Metastasis; Medicine; Medicine & Public Health; Metastases; Metastasis; Mice; Nanog Homeobox Protein - genetics; Neoplastic Stem Cells - pathology; Neoplastic Stem Cells - radiation effects; Oct-4 protein; Octamer Transcription Factor-3 - genetics; Oncology; Receptor, ErbB-2 - genetics; SOXB1 Transcription Factors - genetics; Stem cell transplantation; Stem cells; Transcription factors; Transcription Factors - genetics; Tropism; Tumor Microenvironment - genetics; Tumors; Zinc Finger Protein GLI1 - genetics; Zinc Finger Protein GLI1 - metabolism

Mechanisms for breast cancer metastasis remain unclear. Whether truncated glioma-associated oncogene homolog 1 (TGLI1), a transcription factor known to promote angiogenesis, migration and invasion, plays any role in metastasis of any tumor type has never been investigated. In this study, results of...