The evolution of alternative splicing in glioblastoma under therapy

• Published in: Genome Biology Vol. 22; no. 1; p. 48
• Main Authors: Wang, Lin, Shamardani, Karin, Babikir, Husam, Catalan, Francisca, Nejo, Takahide, Chang, Susan, Phillips, Joanna J, Okada, Hideho, Diaz, Aaron A
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.01.2021; BMC
• Subjects: Alternative Splicing; Antigens; Binding sites; Brain - metabolism; Brain cancer; Brain Neoplasms - genetics; Brain tumors; Cell surface; Clinical trials; Evolution, Molecular; Extracellular matrix; Gene expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioblastoma - genetics; Glioblastoma - therapy; Humans; Immunotherapy; Intracellular Signaling Peptides and Proteins - genetics; Invasiveness; Isoforms; Kinases; Lymphocytes; Lymphocytes T; Neoantigens; Peptides; Protein Isoforms - genetics; Protein Serine-Threonine Kinases - genetics; Proteins; Ribonucleic acid; RNA; RNA-Binding Proteins; T cell receptors; T-Lymphocytes; Tumors

Alternative splicing is a rich source of tumor-specific neoantigen targets for immunotherapy. This holds promise for glioblastomas (GBMs), the most common primary tumors of the adult brain, which are resistant to standard-of-care therapy. Although most clinical trials enroll patients at recurrence,...