Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex - Vetreno, R.P.; Crews, F.T. (Neuroscience, 2012)
Keywords: Addictive behaviors; Adolescent; Adult and adolescent clinical studies; Alcoholism; Alcoholism and acute alcohol poisoning; Animals; Barnes maze; Binge Drinking - genetics; Binge Drinking - metabolism; Biological and medical sciences; Cognition Disorders - chemically induced; Cognition Disorders - psychology; ethanol; Female; Fluorescent Antibody Technique; HMGB1 Protein - biosynthesis; HMGB1 Protein - genetics; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; innate immunity; Maze Learning - drug effects; Medical sciences; Microscopy, Confocal; neuroimmune; Neurology; Prefrontal Cortex - growth & development; Prefrontal Cortex - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; reversal learning; Reversal Learning - drug effects; Toll-Like Receptor 3 - biosynthesis; Toll-Like Receptor 3 - drug effects; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - drug effects; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - genetics; Toxicology; BEC; neuroimmune; IL; IHC; IR; HMGB1; PrL; PFC; OFC; ethanol; LPS; reversal learning; FC2; innate immunity; TLR; Barnes maze; AIE; immunoreactivity; prelimbic cortex; infralimbic cortex; prefrontal cortex; frontal cortex area 2; orbitofrontal cortex; immunohistochemistry; Toll-like receptor; blood ethanol content; high-mobility group box 1; adolescent intermittent ethanol; lipopolysaccharide; Human; Agonist; Ethanol; Alcoholism; Central nervous system; Drinking; Prefrontal cortex; Encephalon; Learning; Acquisition process; Adolescent; Neuroimmunomodulation; Biological receptor