Macroscopic gradients of synaptic excitation and inhibition in the neocortex

• Published in: Nature reviews. Neuroscience Vol. 21; no. 3; pp. 169 - 178
• Main Author: Wang, Xiao-Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2020; Nature Publishing Group
• Subjects: 631/378/116/1925; 631/378/116/2393; 631/378/1595/1636; 631/378/1697; 631/378/3920; Animal Genetics and Genomics; Animals; Artificial intelligence; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Cerebral cortex; Connectome; Cortical Excitability - physiology; Developmental plasticity; Dynamical systems; Excitation (Physiology); Functional plasticity; Gene expression; Humans; Inhibition (Neurophysiology); Mental disorders; Mental Disorders - physiopathology; Models, Neurological; Neocortex; Neocortex - physiology; Nervous system; Neural Inhibition - physiology; Neural networks; Neural Pathways - physiology; Neurobiology; Neurons; Neurons - physiology; Neuroplasticity; Neurosciences; Observations; Perspective; Physiological aspects; Synapses; Synapses - physiology; Transcriptomes; United States

With advances in connectomics, transcriptome and neurophysiological technologies, the neuroscience of brain-wide neural circuits is poised to take off. A major challenge is to understand how a vast diversity of functions is subserved by parcellated areas of mammalian neocortex composed of repetition...