Understanding the epidemiology, clinical characteristics, knowledge and barriers to treatment and prevention of malaria among returning international laborers in northern Vietnam: a mixed-methods study

• Published in: BMC infectious diseases Vol. 22; no. 1; pp. 460 - 14
• Main Authors: Edgel, Kimberly A, Canavati, Sara, Le, Hoi Thi, Tran, Tho Huy, Van Nguyen, Kinh, Nguyen, Trung Vu, Nguyen, Nga Thi, Tran, Hoa Mai, Ngo, Thang Duc, Tran, Duong Thanh, Nguyen, Binh Thi Huong, Tran, Long Khanh, Nguyen, Thu Minh, Whedbee, Rosalie J, Milgotina, Ekaterina I, Martin, Nicholas J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.05.2022; BioMed Central; BMC
• Subjects: Adult; Alien labor; Care and treatment; Data collection; Demographics; Disease transmission; Entomology; Environmental aspects; Epidemiology; Female; Health aspects; Health risks; Hospitals; Humans; Importation; Infections; Infectious diseases; Laboratories; Malaria; Malaria - drug therapy; Malaria - epidemiology; Malaria - prevention & control; Malaria, Vivax - epidemiology; Male; Manual workers; Microscopy; Migration; Mixed methods research; Parasitology; Patient outcomes; Patients; Plasmodium falciparum; Plasmodium malariae; Plasmodium ovale; Plasmodium vivax; Prevention; Prophylaxis; Prospective Studies; Qualitative analysis; Reintroduction; Strands; Travel; Triangulation; Tropical diseases; Vector-borne diseases; Vietnam; Vietnam - epidemiology; Vietnam; United States > US; Africa; Plasmodium falciparum; Plasmodium vivax; Malaria elimination; Vietnam; Key populations; Malaria importation; Migration; Plasmodium ovale; Plasmodium malariae; Population movement
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-022-07322-5

With the decline in local malaria transmission in Vietnam as a result of the National Malaria Control Program (NMCP) elimination activities, a greater focus on the importation and potential reintroduction of transmission are essential to support malaria elimination objectives. We conducted a multi-method assessment of the demographics, epidemiology, and clinical characteristics of imported malaria among international laborers returning from African or Southeast Asian countries to Vietnam. Firstly, we conducted a retrospective review of hospital records of patients from January 2014 to December 2016. Secondly, we conducted a mixed-methods prospective study for malaria patients admitted to the study sites from January 2017 to May 2018 using a structured survey with blood sample collection for PCR analysis and in-depth interviews. Data triangulation of the qualitative and quantitative data was used during analysis. International laborers were young (median age 33.0 years IQR 28.0-39.5 years), predominantly male (92%) adults returning mostly from the African continent (84%) who stayed abroad for prolonged periods (median time 13.5 months; IQR 6.0-331.5 months) and were involved in occupations that exposed them to a higher risk of malaria infection. Epidemiological trends were also similar amongst study strands and included the importation of Plasmodium falciparum primarily from African countries and P. vivax from Southeast Asian countries. Of 11 P. malariae and P. ovale infections across two study strands, 10 were imported from the African continent. Participants in the qualitative arm demonstrated limited knowledge about malaria prior to travelling abroad, but reported knowledge transformation through personal or co-worker's experience while abroad. Interestingly, those who had a greater understanding of the severity of malaria presented to the hospital for treatment sooner than those who did not; median of 3 days (IQR 2.0-7.0 days) versus 5 days (IQR 4.0-9.5 days) respectively. To address the challenges to malaria elimination raised by a growing Vietnamese international labor force, consideration should be given to appropriately targeted interventions and malaria prevention strategies that cover key stages of migration including pre-departure education and awareness, in-country prevention and prophylaxis, and malaria screening upon return.