Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking

• Published in: Computers in biology and medicine Vol. 145; p. 105454
• Main Authors: Wang, Ying, Yuan, Yuan, Wang, Wenting, He, Ying, Zhong, Hong, Zhou, Xiaoxia, Chen, Yong, Cai, Xin-Jun, Liu, Li-qin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.06.2022; Elsevier Limited
• Subjects: 1-Phosphatidylinositol 3-kinase; Acute lung injury; Acute Lung Injury - drug therapy; AKT protein; Apoptosis; Bioavailability; Core protein; Datasets; Drug screening; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Gene expression; GEO datasets; Herbal medicine; Humans; Hydrogenation; Internal Medicine; Lungs; MAP kinase; Medicine, Chinese Traditional; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular modelling; Network Pharmacology; Other; Oxidative stress; Permeability; Pharmacology; Phosphatidylinositol 3-Kinases; Proteins; Qingfeiyin; Simulation; Software; Traditional Chinese medicine; Visualization; China; Traditional Chinese medicine; Acute lung injury; Network pharmacology; GEO datasets; Qingfeiyin; Molecular docking

Qingfeiyin (QFY) is a common Chinese herbal formula for the treatment of acute lung injury (ALI). However, its mechanisms of action are unclear. In this study, we systematically explored the effects and mechanism of action of QFY in ALI using network pharmacology and molecular docking. Active compou...