A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators

• Published in: Molecular cancer Vol. 14; no. 1; p. 206
• Main Authors: Freeman, Jamie, Smith, David, Latinkic, Branko, Ewan, Ken, Samuel, Lee, Zollo, Massimo, Marino, Natascia, Tyas, Lorraine, Jones, Nick, Dale, Trevor C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.12.2015; BioMed Central
• Subjects: Analysis; Animals; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Drug discovery; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic aspects; Genetic transcription; HEK293 Cells; Humans; Protein Interaction Maps; Proteins; TCF Transcription Factors - physiology; Transcription, Genetic; Wnt Proteins - physiology; Wnt Signaling Pathway - drug effects; Xenopus laevis

Wnt/β-catenin signaling is often portrayed as a simple pathway that is initiated by Wnt ligand at the cell surface leading, via linear series of interactions between 'core pathway' members, to the induction of nuclear transcription from genes flanked by β-catenin/TCF transcription factor b...