The genetic variability, phylogeny and functional significance of E6, E7 and LCR in human papillomavirus type 52 isolates in Sichuan, China

• Published in: Virology journal Vol. 18; no. 1; p. 94
• Main Authors: Song, Zhilin, Cui, Yanru, Li, Qiufu, Deng, Junhang, Ding, Xianping, He, Jiaoyu, Liu, Yiran, Ju, Zhuang, Fang, Liyuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.05.2021; BioMed Central; BMC
• Subjects: Alphapapillomavirus - genetics; Amino acids; Antigens; B-lymphocytes; Bayes Theorem; Bayesian analysis; Binding sites; Carcinogenesis; Care and treatment; CD4 antigen; CD8 antigen; CD8-positive T-lymphocytes; Cervical cancer; Cervix; China; Clonal selection; Complications and side effects; Development and progression; Epidemiology; Epitopes; Epitopes, B-Lymphocyte; Female; Gene deletion; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic variability; genetic variation; Genomes; Health aspects; Histocompatibility antigen HLA; Hospitals; Human papillomavirus; Humans; Infections; LCR; Lymphocytes B; Lymphocytes T; Oncogene Proteins, Viral - genetics; Papillomaviridae; Papillomavirus E7 Proteins - genetics; Papillomavirus infections; Papillomavirus Infections - virology; peptides; Phylogenetics; Phylogeny; Polymorphism; Positive selection; prediction; probability; Protein binding; Protein structure; Proteins; Secondary structure; selection pressure; Single-nucleotide polymorphism; Sox9 protein; therapeutics; Transcription Factors; uterine cervical neoplasms; Uterine Cervical Neoplasms - virology; Vaccine Development; Vaccines; Variation; virology; viruses; Womens health; China; E6; E7; Human papillomavirus; Antigen epitopes; LCR; Phylogeny; Transcription factor binding site; Polymorphism

Variations in human papillomavirus (HPV) E6 and E7 have been shown to be closely related to the persistence of the virus and the occurrence and development of cervical cancer. Long control region (LCR) of HPV has been shown multiple functions on regulating viral transcription. In recent years, there...