Replication kinetics and infectivity of SARS-CoV-2 variants of concern in common cell culture models

• Published in: Virology journal Vol. 19; no. 1; p. 76
• Main Authors: Mautner, Lena, Hoyos, Mona, Dangel, Alexandra, Berger, Carola, Ehrhardt, Anja, Baiker, Armin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.04.2022; BioMed Central; BMC
• Subjects: Caco-2; Caco-2 Cells; Carcinoma; Cell culture; Cell Culture Techniques; cell lines; Chlorocebus aethiops; colon; Coronaviruses; COVID-19; COVID-19 infection; Drug screening; drugs; Epidemiology; epithelium; Experiments; genome; Genomes; growth models; Humans; Infections; Infectivity; kidneys; Kinetics; Laboratories; Mutation; neoplasm cells; Omicron; Pandemics; pathogenicity; Propagation; Replication; RNA; SARS-CoV-2; SARS-CoV-2 - genetics; Severe acute respiratory syndrome coronavirus 2; virus replication; Virus research; Viruses; VOC; Germany; United States > US; Cell culture; SARS-CoV-2; Calu-3; Caco-2; Kinetics; Omicron; VOC

During the ongoing Covid-19 pandemic caused by the emerging virus SARS-CoV-2, research in the field of coronaviruses has expanded tremendously. The genome of SARS-CoV-2 has rapidly acquired numerous mutations, giving rise to several Variants of Concern (VOCs) with altered epidemiological, immunologi...