The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China

• Published in: Virology journal Vol. 19; no. 1; p. 14
• Main Authors: He, Jiaoyu, Li, Qiufu, Ma, Shiyu, Li, Tianjun, Chen, Yuning, Liu, Yiran, Cui, Yanru, Peng, Jianying, Shi, Yunfan, Wei, Xia, Ding, Xianping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.01.2022; BioMed Central; BMC
• Subjects: Adaptability; Affinity; Alphapapillomavirus - genetics; Alphapapillomavirus 9; Alphapapillomavirus 9 genus HPV; Amino acid substitution; Amino acids; Analysis; Antigen epitope; Antigens; carcinogenicity; Care and treatment; Cell cycle; Cervical cancer; Cervix; Children & youth; China; China - epidemiology; Clonal selection; Diagnosis; E6 gene; E6 gene polymorphisms; E6 protein; Epitopes; Epitopes, T-Lymphocyte - genetics; family; Female; genes; Genetic polymorphisms; genus; Hospitals; Human Papillomavirus; Human papillomavirus 16; Humans; Immune response; Immune system; immunity; Infections; Invasiveness; Lymphocytes T; Medical research; Mutation; oncogene proteins; Oncogene Proteins, Viral - chemistry; Oncogene Proteins, Viral - genetics; Papillomavirus Infections; Peptides; Phylogeny; Polymorphism; Polymorphism, Single Nucleotide; Positive selection; Positive selection site; Prevention; Probes; Protein structure; Proteins; Repressor Proteins - chemistry; Repressor Proteins - genetics; Reproductive health; Risk factors; Software; T-lymphocytes; Tertiary structure; therapeutics; Uterine Cervical Neoplasms; Vaccines; Womens health; China; Alphapapillomavirus 9 genus HPV; E6 gene polymorphisms; Positive selection site; Human Papillomavirus; Protein structure; Antigen epitope

The Alphapapillomavirus 9 (α-9 HPV) is a member of the Alphapapillomavirus genus and Papillomaviridae family. These viruses are almost all carcinogenic HPV, which is closely related to 75% of invasive cervical cancer worldwide, and has a high prevalence in Sichuan. The carcinogenic function is mainl...