Genetic variability of human papillomavirus type 39 based on E6, E7 and L1 genes in Southwest China

• Published in: Virology journal Vol. 18; no. 1; p. 72
• Main Authors: He, Jiaoyu, Li, Tianjun, Wang, Youliang, Song, Zhilin, Li, Qiufu, Liu, Yiran, Cui, Yanru, Ma, Siyu, Deng, Junhang, Wei, Xia, Ding, Xianping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.04.2021; BioMed Central; BMC
• Subjects: Adaptability; Age groups; Alphapapillomavirus - genetics; Amino acid substitution; Amino acids; Capsid protein; Carcinogenesis; carcinogenicity; Care and treatment; Cervical cancer; Cervix; China; coat proteins; Complications and side effects; computer software; Deoxyribonucleic acid; Development and progression; DNA; DNA Mutational Analysis; E7 and L1 genes; Epitopes; Evolutionary genetics; Female; Gene polymorphism; Genes; Genes, Viral; Genetic aspects; genetic polymorphism; Genetic polymorphisms; Genetic transformation; Genetic variability; Genetic Variation; Health aspects; Hospitals; HPV39; Human papillomavirus; Human papillomavirus type 39; Humans; Immortalization; Immune response; Infections; Internet; L1 gene; Mutation; Negative selection; neoplasms; oncogene proteins; Oncogene Proteins, Viral - genetics; Papillomavirus infections; Papillomavirus Infections - virology; Phylogeny; Positive selection; Proteins; Software; Southwest china; statistical analysis; Tumor proteins; Vaccine Development; Vaccines; virology; viruses; Womens health; China; Southwest china; protein structure; E6; Genetic variability; E7 and L1 genes; HPV39; Cervical cancer; Lineage phylogeny

Human papillomavirus type 39 associated with genital intraepithelial neoplasia and invasive cancers, has a high prevalence in Southwest China. HPV E6, E7 are two main papillomavirus oncoproteins, closely relate to the function of HPV immortalization, cell transformation, and carcinogenesis. L1 is th...