Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization

• Published in: Journal of allergy and clinical immunology Vol. 130; no. 1; pp. 248 - 256.e9
• Main Authors: Santiago, Helton C., LeeVan, Elyse, Bennuru, Sasisekhar, Ribeiro-Gomes, Flavia, Mueller, Ellen, Wilson, Mark, Wynn, Thomas, Garboczi, David, Urban, Joseph, Mitre, Edward, Nutman, Thomas B.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2012; Elsevier; Elsevier Limited
• Subjects: allergens; Allergies; allergy; Allergy and Immunology; Amino Acid Sequence; amino acids; Animals; antibodies; Antibodies - blood; antibody formation; Biological and medical sciences; Blattodea; cockroach; Cockroaches - enzymology; Cockroaches - genetics; Cockroaches - immunology; cross reaction; Cross Reactions; cross-reactivity; Elephantiasis, Filarial - immunology; Epidemiology. Vaccinations; Epitope Mapping; epitopes; Female; filariasis; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; glutathione; Glutathione Transferase - chemistry; Glutathione Transferase - genetics; Glutathione Transferase - immunology; GST; Heligmosomoides; helminth proteins; Helminth Proteins - chemistry; Helminth Proteins - genetics; Helminth Proteins - immunology; helminths; Helminths - enzymology; Helminths - immunology; Humans; hygiene hypothesis; immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; immunoglobulin G; Immunopathology; Infections; Infectious diseases; Insect Proteins - chemistry; Insect Proteins - genetics; Insect Proteins - immunology; Medical sciences; Mice; Mice, Inbred BALB C; Models, Molecular; molecular mimicry; Molecular Mimicry - immunology; Molecular Sequence Data; Parasites; Parasitic diseases; pathogens; patients; Peptides; Phylogeny; Review boards; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sequence Analysis, DNA; Trichostrongyloidea - immunology; Trichostrongyloidiasis - immunology; Wuchereria bancrofti; Wuchereria bancrofti - enzymology; Wuchereria bancrofti - genetics; Wuchereria bancrofti - immunology; aa; OR; hygiene hypothesis; DMSO; cockroach; filariasis; Fil; GST; allergy; cross-reactivity; 3-D; HbGST; Ni-A; WbGST; HDM; Fil-A; Bla g 5; 3-Dimensional; Filaria-uninfected; Heligmosomoides bakeri GST-2; Fil − and atopic; Amino acid; Fil + and atopic; Filaria-infected; Glutathione-S transferase; House dust mite; GST of Wuchereria bancrofti; GST of the cockroach Blattella germanica; Dimethyl sulfoxide; Odds ratio; Allergy; Immunopathology; Enzyme; Transferases; Parasitosis; Helminthiasis; Hypothesis; Infection; Cockroach; Immunology; Glutathione transferase; Nematode disease; Cross reaction; Helmintha; Molecular mimicry; Sensitization; Filariosis; Invertebrata; Hygiene

The extensive similarities between helminth proteins and allergens are thought to contribute to helminth-driven allergic sensitization. The objective of this study was to investigate the cross-reactivity between a major glutathione-S transferase allergen of cockroach (Bla g 5) and the glutathione-S...