Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory

• Published in: Mediators of inflammation Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Wang, Xiu-Li, Liu, Fei-Fei, Liu, Peng, Zhang, Hai-Lin, Zhao, Shuang, Li, Zhao, Guo, Yue-Xian
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Animals; Apoptosis; Brain; Brain research; Cancer; Chemotherapy; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; IL-1β; Inflammation; Interleukin-1beta - metabolism; Interleukins; Learning - drug effects; Male; Maze Learning - drug effects; Memory - drug effects; Neurons; Paclitaxel; Paclitaxel - therapeutic use; Quality of life; Rats; Rats, Sprague-Dawley; Rodents; Spatial discrimination learning; Spatial memory; Thalidomide; Thalidomide - pharmacology; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α

The chemotherapeutic agent paclitaxel is widely used for cancer treatment. Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors. However, the neural mechanisms underlying paclitaxel-induced impairment of learning and memory rem...