The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains

• Published in: NeuroImage (Orlando, Fla.) Vol. 147; pp. 253 - 261
• Main Authors: Chang, Eric H., Argyelan, Miklos, Aggarwal, Manisha, Chandon, Toni-Shay S., Karlsgodt, Katherine H., Mori, Susumu, Malhotra, Anil K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2017; Elsevier Limited
• Subjects: Anisotropy; Brain research; Fractional anisotropy; Hydrogels; Immunofluorescence; Laboratories; Magnetic resonance imaging; Microscopy; Multimodal imaging; Myelin basic protein; Myelination; Nervous system; Neuroimaging; Substantia alba; Tissue clearing; Whole brain immunolabeling; Neuroimaging; Fractional anisotropy; Tissue clearing; Multimodal imaging; Whole brain immunolabeling; Myelin basic protein

Diffusion tensor imaging (DTI) is used extensively in neuroscience to noninvasively estimate white matter (WM) microarchitecture. However, the diffusion signal is inherently ambiguous because it infers WM structure from the orientation of water diffusion and cannot identify the biological sources of...