Dynamic effective connectivity in resting state fMRI

• Published in: NeuroImage (Orlando, Fla.) Vol. 180; no. Pt B; pp. 594 - 608
• Main Authors: Park, Hae-Jeong, Friston, Karl J., Pae, Chongwon, Park, Bumhee, Razi, Adeel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2018; Elsevier Limited; Academic Press
• Subjects: Adult; Bayes Theorem; Bayesian analysis; Brain - physiology; Brain mapping; Brain research; Connectome - methods; Female; Fourier transforms; Functional magnetic resonance imaging; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Models, Neurological; Nerve Net - physiology; Neural networks; Neural Pathways - physiology; Neurosciences; Rest - physiology; Studies; Synaptic plasticity; Synaptic strength; Time series
• DOI: 10.1016/j.neuroimage.2017.11.033
• ISSN: 1053-8119; 1095-9572

Context-sensitive and activity-dependent fluctuations in connectivity underlie functional integration in the brain and have been studied widely in terms of synaptic plasticity, learning and condition-specific (e.g., attentional) modulations of synaptic efficacy. This dynamic aspect of brain connectivity has recently attracted a lot of attention in the resting state fMRI community. To explain dynamic functional connectivity in terms of directed effective connectivity among brain regions, we introduce a novel method to identify dynamic effective connectivity using spectral dynamic causal modelling (spDCM). We used parametric empirical Bayes (PEB) to model fluctuations in directed coupling over consecutive windows of resting state fMRI time series. Hierarchical PEB can model random effects on connectivity parameters at the second (between-window) level given connectivity estimates from the first (within-window) level. In this work, we used a discrete cosine transform basis set or eigenvariates (i.e., expression of principal components) to model fluctuations in effective connectivity over windows. We evaluated the ensuing dynamic effective connectivity in terms of the consistency of baseline connectivity within default mode network (DMN), using the resting state fMRI from Human Connectome Project (HCP). To model group-level baseline and dynamic effective connectivity for DMN, we extended the PEB approach by conducting a multilevel PEB analysis of between-session and between-subject group effects. Model comparison clearly spoke to dynamic fluctuations in effective connectivity – and the dynamic functional connectivity these changes explain. Furthermore, baseline effective connectivity was consistent across independent sessions – and notably more consistent than estimates based upon conventional models. This work illustrates the advantage of hierarchical modelling with spDCM, in characterizing the dynamics of effective connectivity. •We describe efficient estimation of dynamics in resting state effective connectivity.•Spectral DCM and PEB are used to model fluctuations in neuronal coupling over time.•Dynamics in responses are explained in terms of its causes (effective connectivity).•Baseline and dynamic components of the default mode connectivity are identified.