Metabolic engineering to improve production of 3-hydroxypropionic acid from corn-stover hydrolysate in Aspergillus species

• Published in: Biotechnology for biofuels and bioproducts Vol. 16; no. 1; p. 53
• Main Authors: Dai, Ziyu, Pomraning, Kyle R., Deng, Shuang, Kim, Joonhoon, Campbell, Kristen B., Robles, Ana L., Hofstad, Beth A., Munoz, Nathalie, Gao, Yuqian, Lemmon, Teresa, Swita, Marie S., Zucker, Jeremy D., Kim, Young-Mo, Burnum-Johnson, Kristin E., Magnuson, Jon K.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.03.2023; BioMed Central; BMC
• Subjects: 09 BIOMASS FUELS; 3-Hydroxypropionate dehydrogenase; 3-hydroxypropionic acid; Acids; Alanine; Aspartate; Aspartate aminotransferase; aspartate transaminase; aspartic acid; Aspergillus; Aspergillus niger; Aspergillus pseudoterreus; Beta-alanine pathway; Beta-alanine pathway, 3-hydroxypropionic acid, Aspergillus niger, Aspergillus pseudoterreus; biofuels; Biomedical materials; Biosynthesis; Chemical synthesis; Codon; Contaminants; coproducts; Corn; corn stover; Cost benefit analysis; Crop yields; Dehydrogenase; Dehydrogenases; Dextrose; E coli; Environmental aspects; Environmental impact; Enzymes; feedstocks; Fermentation; Flasks; Forecasts and trends; Gene deletion; Genes; Genetic aspects; Genetic engineering; Glucose; Glycerol; Growth; Human influences; humans; hydrolases; Hydrolysates; Intermediates; Lignocellulose; Metabolic engineering; Metabolism; Metabolites; Metabolomics; Methods; Microorganisms; nitrogen; Optimization; oxaloacetic acid; oxidoreductases; Petroleum products; Phosphates; Physiological aspects; plasma membrane; Production processes; Proteomics; Pyruvate carboxylase; Pyruvic acid; Raw materials; species; Stover; succinic acid; Sugar; temperature; Trace elements; Transaminases; Niger; United States; Metabolic engineering; Beta-alanine pathway; Aspergillus pseudoterreus; Aspergillus niger; 3-hydroxypropionic acid

Fuels and chemicals derived from non-fossil sources are needed to lessen human impacts on the environment while providing a healthy and growing economy. 3-hydroxypropionic acid (3-HP) is an important chemical building block that can be used for many products. Biosynthesis of 3-HP is possible; howeve...