Genetic variability, phylogeny and functional implication of the long control region in human papillomavirus type 16, 18 and 58 in Chengdu, China

• Published in: Virology journal Vol. 17; no. 1; p. 106
• Main Authors: Fang, Liyuan, Lin, Xiaoli, Yang, Yasi, Song, Zhilin, Ding, Xianping, Tan, Liping, Gao, Peng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.07.2020; BioMed Central; BMC
• Subjects: Adult; Binding Sites; Carcinogenesis; Cervical cancer; Cervix; China; China - epidemiology; Deoxyribonucleic acid; Development and progression; DNA; Female; Gene expression; Gene Expression Regulation, Viral; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genetic variability; genetic variation; Genomes; Human papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 18 - genetics; Human papillomavirus type 16; Humans; Insertion; Middle Aged; Mutation; neoplasm progression; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomavirus; Papillomavirus infections; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Phylogenetics; Phylogeny; Polymorphism; Polymorphism, Genetic; Prevalence; Single-nucleotide polymorphism; Squamous Intraepithelial Lesions - epidemiology; Squamous Intraepithelial Lesions - virology; therapeutics; Transcription (Genetics); Transcription factor binding sites prediction; Transcription factors; Transcription Factors - genetics; uterine cervical neoplasms; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - virology; virology; Womens health; Young Adult; China; Human papillomavirus; Phylogeny; Transcription factor binding sites prediction; Polymorphism

Long control region (LCR) of human papillomavirus (HPV) has shown multiple functions on regulating viral transcription. The variations of LCR related to different lineages/sub-lineages have been found to affect viral persistence and cervical cancer progression differently. In this study, we focused...