Middle ear packing materials: comparison between absorbable hemostatic gelatine sponge and sugarcane biopolymer sponge in rats

Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. This experimental study aimed to investigate the inflammatory effects of the sugar...

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Published inBrazilian journal of otorhinolaryngology Vol. 80; no. 3; pp. 237 - 244
Main Authors Bunzen, Débora Lopes, Lins, Nathalia, Leal, Mariana de Carvalho, Lira, Mariana Montenegro de Melo, Neto, Silvio da Silva Caldas
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Elsevier Editora Ltda 01.05.2014
Elsevier
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
Subjects
absorbable
Animals
Biocompatible materials
Biocompatible Materials - therapeutic use
Biopolymers
Biopolymers - therapeutic use
Biopolímeros
Ear, Middle - pathology
Ear, Middle - surgery
Esponja de gelatina absorvível
Female
Gelatin Sponge, Absorbable - therapeutic use
Gelatine sponge
Materiais biocompatíveis
Membranes, Artificial
Original
Otologic surgical procedures
OTORHINOLARYNGOLOGY
Porifera
Prospective Studies
Prática diária do otorrinolaringologista
Rats, Wistar
Saccharum
Prática diária do otorrinolaringologista
Otologic surgical procedures
Biopolímeros
Esponja de gelatina absorvível
Materiais biocompatíveis
Biocompatible materials
Gelatine sponge
absorbable
Biopolymers
Gelatine sponge, absorbable
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Abstract Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. This experimental study aimed to investigate the inflammatory effects of the sugarcane biopolymer sponge (BP) in the rat middle ear compared with absorbable gelatin sponge (AGS). Prospective experimental study design. Thirty adult female Wistar rats were allocated to receive the BP sponge into the right ear and AGS into the left ear. Animals were randomly killed at 4 and 12 weeks post-procedure. Qualitative histological assessments were performed to evaluate the inflammatory reaction in the tympanic bullae. The BP sponge caused inflammation more intense and persistent than AGS. The BP was not absorbed during the experiment. Fibrosis was observed only in the ears with AGS. There were thickening of the mucosa and neoangiogenesis in the group of AGS. Despite inflammation, the BP sponge produced less fibrosis and neoangiogenesis compared to AGS. The sponge BP appeared to be a non-absorbable biomaterial in the middle ear. Existem diversos biomateriais que podem ser utilizados na cirurgia otológica para preencher a cavidade da orelha média ou dar suporte a enxertos. A esponja de gelatina absorvível é a mais utilizada, mas pode provocar fibrose e prejudicar a ventilação da orelha média. Investigar os efeitos da reação inflamatória provocada pela esponja do biopolímero da cana-de-açúcar (BP) comparada a esponja de gelatina absorvível (EGA) na mucosa da orelha média de ratos. Estudo experimental prospectivo. A esponja do BP foi implantada na orelha direita e a EGA na orelha esquerda de 30 ratos Wistar fêmeas. Os animais foram sacrificados com 4 e 12 semanas após o procedimento. Avaliação histológica qualitativa foi realizada para verificar a reação inflamatória na bula timpânica. A esponja do BP provocou exsudato inflamatório mais intenso e persistente que a EGA. O BP não foi absorvido durante o tempo de observação. Traves de fibrose foram observadas apenas nos ouvidos com a EGA. Houve espessamento da mucosa e neoangiogênese no grupo da EGA. Apesar da reação inflamatória, a esponja do BP provocou menos fibrose e neoangiogênese quando comparada a EGA. A esponja do BP comportou-se como um biomaterial não-absorvível na orelha média.
AbstractList INTRODUCTION: Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. OBJECTIVE: This experimental study aimed to investigate the inflammatory effects of the sugarcane biopolymer sponge (BP) in the rat middle ear compared with absorbable gelatin sponge (AGS). MATERIALS AND METHODS: Prospective experimental study design. Thirty adult female Wistar rats were allocated to receive the BP sponge into the right ear and AGS into the left ear. Animals were randomly killed at 4 and 12 weeks post-procedure. Qualitative histological assessments were performed to evaluate the inflammatory reaction in the tympanic bullae. RESULTS: The BP sponge caused inflammation more intense and persistent than AGS. The BP was not absorbed during the experiment. Fibrosis was observed only in the ears with AGS. There were thickening of the mucosa and neoangiogenesis in the group of AGS. CONCLUSION: Despite inflammation, the BP sponge produced less fibrosis and neoangiogenesis compared to AGS. The sponge BP appeared to be a non-absorbable biomaterial in the middle ear.
Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. This experimental study aimed to investigate the inflammatory effects of the sugarcane biopolymer sponge (BP) in the rat middle ear compared with absorbable gelatin sponge (AGS). Prospective experimental study design. Thirty adult female Wistar rats were allocated to receive the BP sponge into the right ear and AGS into the left ear. Animals were randomly killed at 4 and 12 weeks post-procedure. Qualitative histological assessments were performed to evaluate the inflammatory reaction in the tympanic bullae. The BP sponge caused inflammation more intense and persistent than AGS. The BP was not absorbed during the experiment. Fibrosis was observed only in the ears with AGS. There were thickening of the mucosa and neoangiogenesis in the group of AGS. Despite inflammation, the BP sponge produced less fibrosis and neoangiogenesis compared to AGS. The sponge BP appeared to be a non-absorbable biomaterial in the middle ear. Existem diversos biomateriais que podem ser utilizados na cirurgia otológica para preencher a cavidade da orelha média ou dar suporte a enxertos. A esponja de gelatina absorvível é a mais utilizada, mas pode provocar fibrose e prejudicar a ventilação da orelha média. Investigar os efeitos da reação inflamatória provocada pela esponja do biopolímero da cana-de-açúcar (BP) comparada a esponja de gelatina absorvível (EGA) na mucosa da orelha média de ratos. Estudo experimental prospectivo. A esponja do BP foi implantada na orelha direita e a EGA na orelha esquerda de 30 ratos Wistar fêmeas. Os animais foram sacrificados com 4 e 12 semanas após o procedimento. Avaliação histológica qualitativa foi realizada para verificar a reação inflamatória na bula timpânica. A esponja do BP provocou exsudato inflamatório mais intenso e persistente que a EGA. O BP não foi absorvido durante o tempo de observação. Traves de fibrose foram observadas apenas nos ouvidos com a EGA. Houve espessamento da mucosa e neoangiogênese no grupo da EGA. Apesar da reação inflamatória, a esponja do BP provocou menos fibrose e neoangiogênese quando comparada a EGA. A esponja do BP comportou-se como um biomaterial não-absorvível na orelha média.
Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. This experimental study aimed to investigate the inflammatory effects of the sugarcane biopolymer sponge (BP) in the rat middle ear compared with absorbable gelatin sponge (AGS). Prospective experimental study design. Thirty adult female Wistar rats were allocated to receive the BP sponge into the right ear and AGS into the left ear. Animals were randomly killed at 4 and 12 weeks post-procedure. Qualitative histological assessments were performed to evaluate the inflammatory reaction in the tympanic bullae. The BP sponge caused inflammation more intense and persistent than AGS. The BP was not absorbed during the experiment. Fibrosis was observed only in the ears with AGS. There were thickening of the mucosa and neoangiogenesis in the group of AGS. Despite inflammation, the BP sponge produced less fibrosis and neoangiogenesis compared to AGS. The sponge BP appeared to be a non-absorbable biomaterial in the middle ear.
INTRODUCTIONSeveral biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may produce fibrosis and impair ventilation of the middle ear. OBJECTIVEThis experimental study aimed to investigate the inflammatory effects of the sugarcane biopolymer sponge (BP) in the rat middle ear compared with absorbable gelatin sponge (AGS). MATERIALS AND METHODSProspective experimental study design. Thirty adult female Wistar rats were allocated to receive the BP sponge into the right ear and AGS into the left ear. Animals were randomly killed at 4 and 12 weeks post-procedure. Qualitative histological assessments were performed to evaluate the inflammatory reaction in the tympanic bullae. RESULTSThe BP sponge caused inflammation more intense and persistent than AGS. The BP was not absorbed during the experiment. Fibrosis was observed only in the ears with AGS. There were thickening of the mucosa and neoangiogenesis in the group of AGS. CONCLUSIONDespite inflammation, the BP sponge produced less fibrosis and neoangiogenesis compared to AGS. The sponge BP appeared to be a non-absorbable biomaterial in the middle ear.
Author Leal, Mariana de Carvalho
Lins, Nathalia
Neto, Silvio da Silva Caldas
Bunzen, Débora Lopes
Lira, Mariana Montenegro de Melo
AuthorAffiliation Universidade Federal de Pernambuco
AuthorAffiliation_xml – name: Universidade Federal de Pernambuco
Author_xml – sequence: 1
  givenname: Débora Lopes
  surname: Bunzen
  fullname: Bunzen, Débora Lopes
  email: dbunzen@gmail.com
  organization: Otorhinolaryngology Service, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil
– sequence: 2
  givenname: Nathalia
  surname: Lins
  fullname: Lins, Nathalia
  organization: Centre of Experimental Research, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil
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  givenname: Mariana de Carvalho
  surname: Leal
  fullname: Leal, Mariana de Carvalho
  organization: Otorhinolaryngology Service, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil
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  givenname: Mariana Montenegro de Melo
  surname: Lira
  fullname: Lira, Mariana Montenegro de Melo
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  givenname: Silvio da Silva Caldas
  surname: Neto
  fullname: Neto, Silvio da Silva Caldas
  organization: Otorhinolaryngology Service, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25153109$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords Prática diária do otorrinolaringologista
Otologic surgical procedures
Biopolímeros
Esponja de gelatina absorvível
Materiais biocompatíveis
Biocompatible materials
Gelatine sponge
absorbable
Biopolymers
Gelatine sponge, absorbable
Language English
Portuguese
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Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
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SSID ssj0067075
Score 2.0254989
Snippet Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used, but it may...
INTRODUCTIONSeveral biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely used,...
INTRODUCTION: Several biomaterials can be used in ear surgery to pack the middle ear or support the graft. The absorbable gelatin sponge is the most widely...
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SubjectTerms absorbable
Animals
Biocompatible materials
Biocompatible Materials - therapeutic use
Biopolymers
Biopolymers - therapeutic use
Biopolímeros
Ear, Middle - pathology
Ear, Middle - surgery
Esponja de gelatina absorvível
Female
Gelatin Sponge, Absorbable - therapeutic use
Gelatine sponge
Materiais biocompatíveis
Membranes, Artificial
Original
Otologic surgical procedures
OTORHINOLARYNGOLOGY
Porifera
Prospective Studies
Prática diária do otorrinolaringologista
Rats, Wistar
Saccharum
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Title Middle ear packing materials: comparison between absorbable hemostatic gelatine sponge and sugarcane biopolymer sponge in rats
URI https://dx.doi.org/10.1016/j.bjorl.2013.08.001
https://www.ncbi.nlm.nih.gov/pubmed/25153109
https://search.proquest.com/docview/1557084314
https://pubmed.ncbi.nlm.nih.gov/PMC9535480
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Volume 80
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