Constriction imposed by basement membrane regulates developmental cell migration

• Published in: PLoS biology Vol. 21; no. 6; p. e3002172
• Main Authors: Molina López, Ester, Kabanova, Anna, Winkel, Alexander, Franze, Kristian, Palacios, Isabel M, Martín-Bermudo, María D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.06.2023
• Subjects: Basement membranes; Basements; Biology and Life Sciences; Cell adhesion & migration; Cell migration; Collagen; Collagen (type IV); Composite materials; Engineering and Technology; Extracellular matrix; Glycoproteins; Heparan sulfate; Insects; Mechanical properties; Membranes; Microscopy; Morphogenesis; Nurse cells; Ovaries; Physical Sciences; Research and Analysis Methods; Stiffness

The basement membrane (BM) is a specialized extracellular matrix (ECM), which underlies or encases developing tissues. Mechanical properties of encasing BMs have been shown to profoundly influence the shaping of associated tissues. Here, we use the migration of the border cells (BCs) of the Drosophi...