Extracellular cyclophilin A possesses chemotaxic activity in cattle

• Published in: Veterinary research (Paris) Vol. 46; no. 1; p. 80
• Main Authors: Takanashi, Satoru, Nochi, Tomonori, Abe, Miku, Itaya, Nanami, Urakawa, Megumi, Sato, Katsuyoshi, Zhuang, Tao, Umemura, Saori, Hayashi, Tomohito, Kiku, Yoshio, Kitazawa, Haruki, Rose, Michael T., Watanabe, Kouichi, Aso, Hisashi
• Format: Journal Article
• Language: English
• Published: England BioMed Central 11.07.2015
• Subjects: Animals; antibodies; binding proteins; bioactive properties; Cattle; Chemotaxis; Cyclophilin A - genetics; Cyclophilin A - metabolism; cyclophilins; cyclosporine; Female; granulocytes; Granulocytes - immunology; Granulocytes - physiology; immunosuppression; inflammation; Life Sciences; Mastitis, Bovine - immunology; Medical research; monocytes; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; thymocytes; Veterinary medicine

Cyclophilin A (CyPA) was originally discovered in bovine thymocytes as a cytosolic binding protein of the immunosuppressive drug cyclosporine A. Recent studies have revealed that in mice and humans, CyPA is secreted from cells in injured or infected tissues and plays a role in recruiting inflammator...