Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore

• Published in: Nature cell biology Vol. 14; no. 6; pp. 614 - 624
• Main Authors: Bock, Lucy J., Pagliuca, Cinzia, Kobayashi, Norihiko, Grove, Ryan A., Oku, Yusuke, Shrestha, Kriti, Alfieri, Claudio, Golfieri, Cristina, Oldani, Amanda, Dal Maschio, Marianna, Bermejo, Rodrigo, Hazbun, Tony R., Tanaka, Tomoyuki U., De Wulf, Peter
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2012; Nature Publishing Group
• Subjects: 631/80/641/1966; 631/80/641/2002; Anaphase; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell cycle; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Chromosomes; Chromosomes, Fungal - metabolism; Developmental Biology; Genetic aspects; Kinases; Kinetochores; Kinetochores - metabolism; Life Sciences; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Oncology; Phosphorylation; Physiological aspects; Protein Binding; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Spindle Apparatus - metabolism; Stem Cells; Yeast; Yeast fungi; Yeasts; United States; United Kingdom; Italy

Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segregation are mediated by the multi-copy KNL1 Spc105 , MIS12 Mtw1 and NDC80 Ndc80  complexes that form the so-called KMN networ...