Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

• Published in: Cell stem cell Vol. 4; no. 3; pp. 263 - 274
• Main Authors: Hooper, Andrea T., Butler, Jason M., Nolan, Daniel J., Kranz, Andrea, Iida, Kaoruko, Kobayashi, Mariko, Kopp, Hans-Georg, Shido, Koji, Petit, Isabelle, Yanger, Kilangsungla, James, Daylon, Witte, Larry, Zhu, Zhenping, Wu, Yan, Pytowski, Bronislaw, Rosenwaks, Zev, Mittal, Vivek, Sato, Thomas N., Rafii, Shahin
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 06.03.2009; Cell Press
• Subjects: Animals; Ataxin-1; Ataxins; Biological and medical sciences; Blood Vessels - physiology; Bone Marrow - blood supply; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Endothelium, Vascular - radiation effects; Fundamental and applied biological sciences. Psychology; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - physiology; Mice; Mice, Knockout; Molecular and cellular biology; Nerve Tissue Proteins - biosynthesis; Nuclear Proteins - biosynthesis; Regeneration; Sequence Deletion; Signal Transduction; STEMCELL; Vascular Endothelial Growth Factor Receptor-2 - genetics; Vascular Endothelial Growth Factor Receptor-2 - metabolism; Whole-Body Irradiation; STEMCELL; Engraftment; Regeneration; Endothelial cell; Vascular endothelial growth factor receptor 2; Hematopoiesis

Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic stem and progenitor cells (HSPCs) and restoration of hematopoiesis. We found that chemotherapy and sublethal irradiation in...