Evaluation of two sexual-stage antigens as bivalent transmission-blocking vaccines in rodent malaria

• Published in: Parasites & vectors Vol. 14; no. 1; p. 241
• Main Authors: Yang, Fan, Liu, Fei, Yu, Xinxin, Zheng, Wenqi, Wu, Yudi, Qiu, Yue, Jin, Ying, Cui, Liwang, Cao, Yaming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.05.2021; BioMed Central; BMC
• Subjects: Animals; Antibodies; Antibodies, Protozoan - blood; Antigens; Antisera; Blocking antibodies; Developmental stages; Disease control; Disease Models, Animal; Disease transmission; Drug Evaluation, Preclinical; Drug resistance; Dual-antigen; E coli; ELISA; Enzyme-linked immunosorbent assay; Escherichia coli; Female; Fusion protein; Gametes; Gametocytes; Human diseases; Humans; Immunization; Immunological interference; Immunological research; Immunology; In vivo methods and tests; Insecticides; Interference; Malaria; Malaria - blood; Malaria - parasitology; Malaria - prevention & control; Malaria - transmission; Malaria vaccine; Malaria Vaccines - administration & dosage; Malaria Vaccines - genetics; Malaria Vaccines - immunology; Mice; Mice, Inbred BALB C; Mosquitoes; ookinetes; Parasites; Physiological aspects; Plasmodium berghei - genetics; Plasmodium berghei - growth & development; Plasmodium berghei - immunology; Prevention; Proteins; Protozoan Proteins - administration & dosage; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Public health; recombinant fusion proteins; Recombinants; rodents; sexual development; Sexual stages; Sodium; Target recognition; Transmission-blocking activity; Transmission-blocking vaccine; Vaccines; Vaccines, Combined - administration & dosage; Vaccines, Combined - genetics; Vaccines, Combined - immunology; Vector-borne diseases; Western blotting; zygote; Zygotes; China; Beijing China; United States > US; Immunological interference; Transmission-blocking activity; Transmission-blocking vaccine; Dual-antigen

Transmission-blocking vaccine (TBV) is a promising strategy for malaria elimination. It is hypothesized that mixing or fusing two antigens targeting different stages of sexual development may provide higher transmission-blocking activity than these antigens used individually. A chimeric protein comp...