Evolutionary trajectory of SARS-CoV-2 and emerging variants

The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoV...

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Published inVirology journal Vol. 18; no. 1; p. 166
Main Authors Singh, Jalen, Pandit, Pranav, McArthur, Andrew G., Banerjee, Arinjay, Mossman, Karen
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 13.08.2021
BioMed Central
BMC
Subjects
Animals
Betacoronavirus 1
Coronavirus
Coronavirus 229E, Human - genetics
Coronavirus 229E, Human - immunology
Coronavirus 229E, Human - pathogenicity
Coronavirus infections
Coronavirus NL63, Human - genetics
Coronavirus NL63, Human - immunology
Coronavirus NL63, Human - pathogenicity
Coronavirus OC43, Human - genetics
Coronavirus OC43, Human - immunology
Coronavirus OC43, Human - pathogenicity
Coronaviruses
COVID-19
COVID-19 - transmission
COVID-19 - virology
COVID-19 Vaccines
disease severity
Disease transmission
Evolution
Genetic aspects
Health aspects
Humans
Immunity
Methods
Middle East respiratory syndrome
Mutation
Mutations
neutralization
Pathogenicity
Prevalence studies (Epidemiology)
Review
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
SARS-CoV-2 - pathogenicity
Selection
Severe acute respiratory syndrome coronavirus 2
Variants
virology
Virus research
virus transmission
viruses
Zoonoses
Canada
China
Hubei China
Mutations
Variants
Evolution
SARS-CoV-2
Coronavirus
Selection
Online AccessGet full text

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Abstract The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity.
AbstractList The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity.
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity.The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity.
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity. Keywords: SARS-CoV-2, Coronavirus, Evolution, Mutations, Selection, Variants
Abstract The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary history and factors that enable some CoVs to co-exist with humans as low pathogenic and endemic infections (HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1), while others, such as SARS-CoV, MERS-CoV and SARS-CoV-2 have evolved to cause severe disease. In this review, we highlight the origins of all known HCoVs and map positively selected for mutations within HCoV proteins to discuss the evolutionary trajectory of SARS-CoV-2. Furthermore, we discuss emerging mutations within SARS-CoV-2 and variants of concern (VOC), along with highlighting the demonstrated or speculated impact of these mutations on virus transmission, pathogenicity, and neutralization by natural or vaccine-mediated immunity.
ArticleNumber 166
Audience Academic
Author McArthur, Andrew G.
Singh, Jalen
Mossman, Karen
Pandit, Pranav
Banerjee, Arinjay
Author_xml – sequence: 1
  givenname: Jalen
  surname: Singh
  fullname: Singh, Jalen
– sequence: 2
  givenname: Pranav
  surname: Pandit
  fullname: Pandit, Pranav
– sequence: 3
  givenname: Andrew G.
  surname: McArthur
  fullname: McArthur, Andrew G.
– sequence: 4
  givenname: Arinjay
  surname: Banerjee
  fullname: Banerjee, Arinjay
– sequence: 5
  givenname: Karen
  orcidid: 0000-0002-1725-5873
  surname: Mossman
  fullname: Mossman, Karen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34389034$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1101/2021.01.15.426911
10.1016/j.cell.2020.05.015
10.1371/journal.ppat.1008421
10.1016/bs.aivir.2018.01.001
10.2139/ssrn.3556998
10.1056/NEJMoa2001017
10.1128/JVI.02605-06
10.1186/s12985-016-0544-0
10.1126/science.abe8499
10.1101/2021.02.14.431043
10.1038/s41467-017-01706-x
10.1101/2020.12.30.20249034
10.1002/jmv.26264
10.1101/2021.03.06.434059
10.2139/ssrn.3550308
10.1016/j.bbrc.2020.03.047
10.1099/vir.0.043117-0
10.1186/s12985-017-0907-1
10.1002/jmv.25758
10.1128/JVI.00127-20
10.1101/2021.02.12.21251658
10.1128/mBio.01985-18
10.1038/s41564-020-0771-4
10.1016/j.ijid.2020.05.071
10.1111/odi.13447
10.1128/JVI.02274-15
10.1101/2021.06.28.449914
10.3390/vaccines8030355
10.1073/pnas.2008176117
10.1016/j.chom.2017.02.008
10.1128/JVI.01498-14
10.3201/eid1910.130946
10.1046/j.1440-1843.2003.00518.x
10.3201/eid2512.190882
10.1038/srep14480
10.1099/vir.0.044628-0
10.1038/s41564-020-00813-8
10.1038/s41591-020-0965-6
10.1016/j.ijid.2020.08.052
10.1128/JVI.79.24.15189-15198.2005
10.1017/S0950268814002702
10.1101/2020.08.23.20180281
10.1016/j.cell.2020.09.032
10.1101/2021.02.08.21251393
10.1128/JVI.00842-09
10.1038/s41586-020-2601-5
10.1038/s41586-020-2313-x
10.1007/s11427-020-1645-7
10.1016/j.virol.2017.03.019
10.1128/JVI.79.2.884-895.2005
10.1016/S0140-6736(21)00183-5
10.1016/j.sjbs.2020.11.077
10.1101/2021.05.04.21256637
10.1016/j.cub.2020.06.031
10.1186/s12929-020-00665-8
10.1016/j.bbrc.2020.11.080
10.3201/eid1911.131172
10.1101/2021.01.12.426407
10.1016/S0952-7915(99)00048-5
10.1017/S0950268800048019
10.1016/j.jinf.2013.03.015
10.1016/j.antiviral.2018.09.009
10.1038/s41420-019-0181-7
10.1056/NEJMe2009758
10.1016/bs.aivir.2016.08.008
10.1101/2020.03.02.974139
10.3390/v4123689
10.1128/mSystems.00266-20
10.1038/nchembio.77
10.3390/v2081803
10.1128/mBio.02325-17
10.1099/vir.0.81662-0
10.1038/s41392-019-0089-y
10.1101/2021.05.28.446163
10.1016/j.virusres.2014.09.009
10.1016/0042-6822(92)91195-Z
10.1002/jmv.26597
10.1056/NEJMoa1211721
10.1016/j.cell.2020.06.043
10.1038/s41586-021-03207-w
10.1093/infdis/jiy098
10.2807/1560-7917.ES2013.18.50.20662
10.1128/mSphere.00408-20
10.1016/j.ijid.2020.08.076
10.3389/fmicb.2019.01813
10.3390/diseases4030026
10.1038/srep21878
10.1371/journal.ppat.1009619
10.1016/j.virusres.2020.198074
10.1007/s00705-020-04911-0
10.1038/s41598-020-74089-7
10.1101/2020.12.23.20248598
10.1016/S1473-3099(20)30484-9
10.1016/j.molcel.2020.04.022
10.1128/JVI.01052-08
10.1101/2021.01.10.426143
10.7150/ijbs.45472
10.1038/s41586-020-2598-9
10.1073/pnas.2021785118
10.1038/s41598-020-73820-8
10.24171/j.phrp.2020.11.3.05
10.1038/s41579-018-0118-9
10.3390/jcm9082399
10.1101/2020.05.23.104919
10.7554/eLife.61312
10.1128/JVI.01048-15
10.1093/infdis/jiaa392
10.1016/bs.aivir.2019.08.002
10.1016/j.virol.2017.07.019
10.1016/j.cell.2020.07.012
10.1016/j.jiph.2020.06.030
10.1093/infdis/jiaa345
10.1101/2020.02.07.939207
10.12688/wellcomeopenres.15812.2
10.3201/eid2201.151340
10.1016/j.cell.2020.03.035
10.1016/S0140-6736(20)30251-8
10.1101/2020.07.22.20159905
10.1101/2021.01.13.426558
10.1101/2020.10.27.357731
10.1038/s41467-020-18440-6
10.1128/JVI.02988-15
10.1073/pnas.1604472113
10.3855/jidc.12425
10.1093/ve/vev023
10.1073/pnas.0409608102
10.1371/journal.pbio.3001236
10.1128/mBio.01062-13
10.1128/mBio.00019-16
10.1056/NEJMoa2108891
10.1126/science.abb5793
10.1038/s41598-018-37481-y
10.1101/2021.03.31.437925
10.1016/j.medntd.2020.100043
10.1038/nm1024
10.1016/j.cell.2020.02.058
10.1016/j.bbrc.2020.05.206
10.1073/pnas.1902840116
10.1038/srep11451
10.1001/jama.2020.27124
10.1038/s41586-020-2012-7
10.1038/s41467-021-21240-1
10.1056/NEJMoa030747
10.1016/j.tree.2020.12.002
10.3389/fimmu.2020.610688/full#B23
10.1128/JVI.78.16.8824-8834.2004
10.1101/2020.07.26.219741
10.1038/s41467-021-21034-5
10.1177/1176934320965149
10.1016/j.virusres.2004.05.002
10.1101/2020.12.05.20241927
10.1371/journal.ppat.1006698
10.2807/1560-7917.ES.2017.22.13.30494
10.1016/j.virusres.2008.12.011
10.1016/j.jmb.2006.09.074
10.1038/s41586-020-2852-1
10.1038/s41586-018-0010-9
10.1126/science.abc8665
10.1101/2020.12.29.424708
10.1101/2020.11.28.20237016
10.1128/JVI.06540-11
10.1128/JVI.79.5.3223-3225.2005
10.1101/2021.01.25.427846
10.2139/ssrn.3551767
10.1038/s41392-020-0190-2
10.1038/s41564-020-0770-5
10.3390/ijms22041695
10.1038/s41586-021-03777-9
10.1056/NEJMc2102017
10.1126/science.abc1932
10.1038/s41598-020-61432-1
10.1101/2021.01.27.426895
10.1101/2020.12.19.20248567
10.1099/jgv.0.001439
10.1101/2021.04.22.440932
10.1007/s11427-020-1692-1
10.1073/pnas.2004168117
10.1101/2021.04.30.441434
10.1016/j.meegid.2020.104351
10.1101/2021.01.25.427948
10.3181/00379727-121-30734
10.1101/2020.11.06.372037
10.1038/s41591-021-01270-4
10.1126/science.1087139
10.1186/1743-422X-6-131
10.1101/2021.05.08.443253
10.1038/s41586-020-2286-9
10.1126/science.1092002
10.1101/2020.12.14.422555
10.1093/cid/ciaa1275ciaa1275
10.1002/jmv.25700
10.1101/2021.02.02.21250799
10.1016/j.jinf.2021.01.025
10.1126/science.aac8608
10.1016/S1473-3099(20)30120-1
10.1101/2021.01.14.426475
10.1186/s12967-020-02344-6
10.1016/j.chom.2020.11.007
10.1016/j.bbrc.2020.10.045
10.1101/2020.09.30.318311
10.1111/aje.12759
10.1101/2021.01.19.21249840
10.1080/00016480252814207
10.3201/eid2607.200282
10.1016/j.chom.2021.02.017
10.1101/2020.12.28.20248906
10.1073/pnas.57.4.933
10.1155/2006/152612
10.1038/nm.3985
10.1371/journal.pone.0240079
10.1177/135965350701200S01.1
10.1038/s41591-020-0820-9
10.1016/j.cell.2020.08.012
10.1038/35072023
10.3389/fmicb.2020.580137/full
10.1038/s41423-020-0374-2
10.1086/507044
10.1136/bmj.n359
10.1101/2020.11.19.389916
10.1126/science.abd3871
10.1016/j.mehy.2020.110330
10.1248/bpb.b17-00241
10.1128/JVI.00906-12
10.1056/NEJMc2025179
10.1016/j.cell.2020.09.037
10.3389/fmicb.2020.550674
10.1016/S0140-6736(19)33221-0
10.1016/S0065-3527(06)66005-3
10.1016/j.celrep.2020.108234
10.1101/2020.12.23.424283
10.1128/mSphere.00819-20
10.1128/MMBR.00015-08
10.3201/eid1903.121503
10.1360/04wc0153
10.1080/22221751.2020.1717999
10.1126/science.abe5960
10.1016/j.cub.2020.03.022
10.1136/bmjopen-2020-041397
10.1038/nature12711
10.1371/journal.pone.0242537
10.1016/S0140-6736(21)01290-3
10.1101/2021.06.26.21259487
10.1093/nsr/nwaa036
10.1016/S1672-0229(05)03004-4
10.1186/1743-422X-6-79
10.3390/v12050502
10.1101/2020.10.25.20219063
10.1099/jgv.0.001491
10.1093/infdis/jiaa161
10.1128/JVI.79.3.1595-1604.2005
10.1016/j.tim.2013.05.005
10.1101/2020.05.24.111823
10.4161/auto.29309
10.1016/j.tim.2016.09.001
10.1016/j.cell.2021.01.037
10.3201/eid2206.160192
10.1038/s41586-020-2008-3
10.1111/ijcp.13525
10.1002/jmv.27062
10.1016/j.jmb.2020.07.009
10.3201/eid2701.203515
10.1186/s43042-020-00116-x
10.1128/JVI.01586-08
10.2471/BLT.20.253591
10.1371/journal.pgen.1000304
10.1128/JVI.01953-16
10.1016/j.jinf.2020.03.058
10.1016/j.tim.2016.03.003
10.1101/2020.05.22.111344
10.1101/2020.12.21.20248640
10.1128/JVI.01381-18
10.1126/science.abg3055
10.1101/2021.02.03.429646
10.1073/pnas.0400762101
10.1038/s41467-021-21006-9
10.3389/fpubh.2020.567184/full
10.1016/j.virusres.2016.05.023
10.1101/2020.12.23.424229
10.3201/eid1509.090224
10.1016/j.antiviral.2020.104742
10.1016/0042-6822(90)90530-5
10.3389/fmicb.2020.01800/full
10.1016/j.apsb.2020.02.008
10.1038/s41591-020-1083-1
10.1074/jbc.M500662200
10.1007/s00109-020-01931-w
10.1038/s41423-020-0514-8
10.3390/v11010041
10.1038/s41467-019-10280-3
10.1038/sj.emboj.7600640
10.1096/fj.201802418R
10.1016/j.meegid.2003.08.001
10.1101/2020.03.16.20034470
10.1038/s41422-020-0366-x
10.4155/fdd-2020-0012
10.1016/j.coviro.2011.10.012
10.1038/s41423-020-0485-9
10.1101/2020.12.28.424451
10.1128/mBio.00373-17
10.1101/2021.04.02.438288
10.1093/infdis/jiv476
10.1093/cid/ciaa1421
10.1038/s41467-020-19808-4
10.1080/22221751.2020.1852892
10.1139/y98-097
10.1007/s00705-020-04750-z
10.1101/2021.02.21.21252137
10.1126/science.abg6105
10.1126/science.abd0831
10.3390/ijms18102138
10.1101/2020.05.19.20107144
10.1038/s41586-020-2550-z
10.1093/infdis/jiy018
10.1128/JVI.02582-15
10.1021/acschemneuro.0c00596
10.1038/s41586-020-2169-0
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Keywords Mutations
Variants
Evolution
SARS-CoV-2
Coronavirus
Selection
Language English
License 2021. The Author(s).
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References 1633_CR146
R Sarkar (1633_CR218) 2021; 166
RJ Shephard (1633_CR240) 1998; 76
MC Wong (1633_CR39) 2020
NG Davies (1633_CR79) 2021; 372
GM Pavlović-Lažetić (1633_CR286) 2005; 3
SL Senanayake (1633_CR331) 2020; 2
X Li (1633_CR18) 2020; 63
M Wardeh (1633_CR271) 2021; 12
BM Alraddadi (1633_CR26) 2016; 22
MJG Bakkers (1633_CR278) 2017; 21
European Centre for Disease Prevention and Control (1633_CR190) 2021
RW Aldridge (1633_CR253) 2020; 5
CM Voloch (1633_CR192) 2020
CK Vasques Nonaka (1633_CR193) 2021; 27
HA Mohd (1633_CR25) 2016; 13
A Banerjee (1633_CR30) 2019; 11
C Gaebler (1633_CR179) 2021; 591
DA Collier (1633_CR173) 2021
D Forni (1633_CR290) 2016; 90
H Xu (1633_CR335) 2020
M Becerra-Flores (1633_CR114) 2020; 74
EB Hodcroft (1633_CR216) 2021
VD Menachery (1633_CR332) 2014; 194
G Tonkin-Hill (1633_CR125) 2020
D Vijaykrishna (1633_CR22) 2007; 81
J Luan (1633_CR175) 2020; 526
R Ralph (1633_CR29) 2020; 14
Y Kim (1633_CR152) 2016; 7
SA Kemp (1633_CR92) 2020
NS Ogando (1633_CR330) 2019; 10
1633_CR130
NJ MacLachlan (1633_CR6) 2017
J Braun (1633_CR268) 2020; 587
D Shin (1633_CR323) 2020; 587
ZA Memish (1633_CR301) 2013; 19
H-D Song (1633_CR314) 2005; 102
S Xia (1633_CR165) 2020; 5
P Kellam (1633_CR264) 2020; 101
CBF Vogels (1633_CR195) 2021; 19
A Muik (1633_CR207) 2021; 371
Y Guan (1633_CR281) 2003; 302
AG Wrobel (1633_CR43) 2020; 12
T Zhang (1633_CR283) 2020; 30
NL Ithete (1633_CR300) 2013; 19
H Kleine-Weber (1633_CR317) 2019; 93
A Annan (1633_CR304) 2013; 19
L van der Hoek (1633_CR309) 2004; 10
X-D Lin (1633_CR51) 2017; 507
Y Wan (1633_CR159) 2020; 94
H Lim (1633_CR174) 2020; 10
Y Lim (1633_CR12) 2016; 4
CM Sánchez (1633_CR69) 1992; 190
VD Menachery (1633_CR31) 2015; 21
E Issa (1633_CR133) 2020; 5
1633_CR162
M McCallum (1633_CR163) 2021
Y Tao (1633_CR20) 2017; 91
European Centre for Disease Prevention and Control (1633_CR15) 2021
1633_CR93
J Seow (1633_CR259) 2020; 5
K Pyrc (1633_CR87) 2006; 364
L Ren (1633_CR84) 2015; 5
VJ Munster (1633_CR24) 2016; 6
L Yurkovetskiy (1633_CR112) 2020; 183
MS Mehand (1633_CR16) 2018; 159
JC Leao (1633_CR285) 2021
Y Liu (1633_CR208) 2021; 384
X Zhao (1633_CR46) 2020; 8
J Mateus (1633_CR266) 2020; 370
M Gandhi (1633_CR274) 2020; 382
JR St. Jean (1633_CR277) 2004; 78
Y Weisblum (1633_CR91) 2020; 9
S Paynter (1633_CR238) 2015; 143
VV Edara (1633_CR206) 2021
K Duan (1633_CR270) 2020; 117
S Sanche (1633_CR250) 2020; 26
Y Ren (1633_CR134) 2020; 17
RM Bush (1633_CR80) 2001; 2
R Lorenzo-Redondo (1633_CR115) 2020
M Yarmarkovich (1633_CR168) 2020; 1
E Kudo (1633_CR242) 2019; 116
A Naeem (1633_CR287) 2020; 12
A Banerjee (1633_CR71) 2020; 101
S Pfefferle (1633_CR342) 2009; 6
Y Sakai (1633_CR324) 2017; 510
1633_CR183
D Weissman (1633_CR113) 2020
C Reusken (1633_CR28) 2013; 18
1633_CR78
M Kanzawa (1633_CR234) 2020; 222
SA Goldstein (1633_CR272) 2021
Y Shu (1633_CR102) 2017; 22
S-M Chaw (1633_CR135) 2020; 27
A Audi (1633_CR232) 2020
Z-W Ye (1633_CR275) 2020; 16
Y Wang (1633_CR119) 2021; 93
AJ Greaney (1633_CR154) 2021; 29
EJ Snijder (1633_CR328) 2016; 96
S Lau (1633_CR289) 2017; 18
S Su (1633_CR1) 2016; 24
D Wang (1633_CR224) 2020; 3
1633_CR171
K Xiao (1633_CR42) 2020; 583
1633_CR170
N Le Bert (1633_CR267) 2020; 584
J Chen (1633_CR157) 2020; 432
1633_CR297
R Butowt (1633_CR109) 2020; 11
1633_CR89
T Koyama (1633_CR117) 2020; 98
TG Flower (1633_CR137) 2021; 118
European Centre for Disease Prevention and Control (1633_CR346) 2021
H Zhou (1633_CR34) 2020
P Zhou (1633_CR32) 2020; 579
AB Gussow (1633_CR58) 2020; 117
X-X Qu (1633_CR316) 2005; 280
JSM Sabir (1633_CR60) 2016; 351
H Xia (1633_CR127) 2020; 33
TP Peacock (1633_CR167) 2020
VM Corman (1633_CR55) 2016; 113
X Xie (1633_CR213) 2021; 27
M Hoffmann (1633_CR166) 2020; 78
JF-W Chan (1633_CR66) 2013; 21
D Forni (1633_CR139) 2017; 25
AWD Edridge (1633_CR252) 2020; 26
GISAID (1633_CR97) 2021
H Tu (1633_CR158) 2021
DR Adney (1633_CR23) 2016; 22
YL Siu (1633_CR143) 2008; 82
N Barretto (1633_CR322) 2005; 79
G Dudas (1633_CR131) 2016
SR Dominguez (1633_CR86) 2012; 93
A Grifoni (1633_CR265) 2020; 181
R Eccles (1633_CR241) 2002; 122
C Ceraolo (1633_CR96) 2020; 92
KR McCarthy (1633_CR90) 2020
SM Kissler (1633_CR233) 2020; 368
Y Galipeau (1633_CR256) 2020; 11
TT Nguyen (1633_CR116) 2020; 15
Q Gao (1633_CR269) 2020; 369
J Cui (1633_CR3) 2019; 17
M Pachetti (1633_CR121) 2020; 18
AS Monto (1633_CR235) 2020; 222
Y Zhang (1633_CR136) 2020
ArcGIS. (1633_CR11) 2020
L van der Hoek (1633_CR8) 2007; 12
M Touma (1633_CR13) 2020; 98
J Huynh (1633_CR308) 2012; 86
DM Patrick (1633_CR263) 2006; 17
KA Callow (1633_CR255) 1990; 105
SKP Lau (1633_CR140) 2015; 89
1633_CR194
S Xia (1633_CR219) 2020; 17
SJ Anthony (1633_CR302) 2017; 8
C-M Lin (1633_CR4) 2016; 226
Q Guan (1633_CR95) 2020; 100
National Institute of Infectious Diseases (1633_CR189) 2021
F Grabowski (1633_CR161) 2021
PS Masters (1633_CR142) 2006
K McIntosh (1633_CR306) 1967; 57
European Centre for Disease Prevention and Control (1633_CR99) 2020
S Di Giacomo (1633_CR199) 2021; 93
C Motozono (1633_CR197) 2021
K-L Siu (1633_CR334) 2019; 33
M Mejdani (1633_CR221) 2021
M Frieman (1633_CR19) 2008; 72
K-H Chan (1633_CR262) 2013; 67
BO Villoutreix (1633_CR188) 2021; 22
P Zhou (1633_CR5) 2018; 556
KP Alekseev (1633_CR65) 2008; 82
TN Starr (1633_CR311) 2020; 182
RA Mansbach (1633_CR108) 2020
P Mlcochova (1633_CR201) 2021
C Baruah (1633_CR325) 2020
M Alnazawi (1633_CR50) 2017; 40
P Liu (1633_CR45) 2020; 16
SKP Lau (1633_CR303) 2018; 218
G Nelson (1633_CR176) 2021
CT Cornillez-Ty (1633_CR321) 2009; 83
B Hu (1633_CR280) 2017; 13
S Wacharapluesadee (1633_CR40) 2021; 12
Y Hirotsu (1633_CR228) 2021; 17
X-Y Ge (1633_CR53) 2013; 503
A Rambaut (1633_CR347) 2020; 5
F Tea (1633_CR223) 2020
F Fratev (1633_CR187) 2020
L Zinzula (1633_CR169) 2020; 538
WR Gallaher (1633_CR81) 2020; 165
EC Sabino (1633_CR186) 2021; 397
JS Rest (1633_CR62) 2003; 3
AS Lauring (1633_CR105) 2021; 325
N Zhu (1633_CR294) 2020; 382
E Farag (1633_CR27) 2019; 25
JS Min (1633_CR118) 2020; 9
E Petersen (1633_CR249) 2020; 20
L Zhang (1633_CR103) 2020; 11
E Volz (1633_CR77) 2021
JA Plante (1633_CR106) 2020; 325
M Cotten (1633_CR288) 2014; 5
OE Omotoso (1633_CR111) 2020; 21
J-Y Lam (1633_CR337) 2020; 9
B Bartolini (1633_CR147) 2020
C Mavian (1633_CR76) 2020
D Voss (1633_CR340) 2009; 6
CO Barnes (1633_CR181) 2020; 588
1633_CR202
KK-W To (1633_CR149) 2020
1633_CR204
VM Corman (1633_CR282) 2014; 88
S Wu (1633_CR132) 2020; 93
A Dominguez Andres (1633_CR344) 2020; 27
RN Kirchdoerfer (1633_CR120) 2019; 10
E Andreano (1633_CR180) 2020
EB Hodcroft (1633_CR150) 2020
A Wu (1633_CR156) 2021; 29
Z Wu (1633_CR296) 2016; 213
PCY Woo (1633_CR2) 2012; 86
PA Gröhs Ferrareze (1633_CR184) 2021
C Wu (1633_CR326) 2020; 10
PCY Woo (1633_CR67) 2010; 2
J Shaman (1633_CR261) 2020; 370
C Drosten (1633_CR298) 2003; 348
A Moreno (1633_CR305) 2017; 14
T Tomaszewski (1633_CR123) 2020; 16
D Benvenuto (1633_CR129) 2020; 81
JC Santos (1633_CR160) 2021
AC Walls (1633_CR333) 2020; 181
S Ilmjärv (1633_CR122) 2020
The Chinese SARS Molecular Epidemiology Consortium (1633_CR138) 2004; 303
C Coelho (1633_CR327) 2020; 15
JW Tang (1633_CR312) 2006; 194
B Coutard (1633_CR33) 2020; 176
E Dong (1633_CR248) 2020; 20
L Vijgen (1633_CR276) 2005; 79
TP Peacock (1633_CR203) 2021
M Bolles (1633_CR63) 2011; 1
Y Cárdenas-Conejo (1633_CR126) 2020; 92
JK Taylor (1633_CR341) 2015; 89
RHM Price (1633_CR236) 2019; 9
Y-Z Zhang (1633_CR35) 2020; 181
S Cherian (1633_CR196) 2021
EC Thomson (1633_CR205) 2021; 184
J Lopez Bernal (1633_CR215) 2021
A Baum (1633_CR182) 2020; 369
M McCallum (1633_CR229) 2021
W Li (1633_CR153) 2005; 24
DL Bugembe (1633_CR225) 2021
FJ Ibarrondo (1633_CR258) 2020; 383
F Wu (1633_CR37) 2020; 579
G Dudas (1633_CR226) 2021
LA Nikolai (1633_CR273) 2020; 100
AN Alshukairi (1633_CR17) 2018; 9
YJ Hou (1633_CR107) 2020; 370
GJ Harper (1633_CR239) 1961; 59
MA Tortorici (1633_CR82) 2019
J Wise (1633_CR172) 2021; 372
1633_CR101
R He (1633_CR141) 2004; 105
Q Li (1633_CR198) 2020; 182
T Day (1633_CR36) 2020; 30
N Perveen (1633_CR57) 2021; 28
PCY Woo (1633_CR279) 2005; 79
D Forni (1633_CR220) 2015; 5
PG Choe (1633_CR260) 2021; 27
A Choi (1633_CR210) 2021
B Chen (1633_CR7) 2020; 5
National Center for Biotechnology Information (1633_CR319) 2020
ZA Memish (1633_CR10) 2020; 395
L Vijgen (1633_CR68) 2005; 79
Z Yuan (1633_CR315) 2004; 49
J-S Kim (1633_CR217) 2020; 11
J Zhao (1633_CR47) 2020; 11
H-W Jiang (1633_CR343) 2020; 17
PK Kiyuka (1633_CR85) 2018; 217
DL Hurdiss (1633_CR292) 2020; 11
K Shirato (1633_CR293) 2012; 93
B Chen (1633_CR246) 2020; 10
D Lehmann (1633_CR44) 2020; 58
BM Crossley (1633_CR56) 2012; 4
H Tegally (1633_CR100) 2020
V Novaes Rocha (1633_CR48) 2020; 145
Z Liu (1633_CR178) 2021
DE Gordon (1633_CR345) 2020; 583
B Korber (1633_CR104) 2020; 182
MH Cheng (1633_CR177) 2021
1633_CR212
K-J Jang (1633_CR329) 2020; 10
M Chan-Yeung (1633_CR9) 2003; 8
D Chibo (1633_CR83) 2006; 87
L Piccoli (1633_CR155) 2020; 183
1633_CR211
D Tandel (1633_CR227) 2021
World Health Organization (1633_CR230) 2021
D Mercatelli (1633_CR94) 2020; 11
B Zhang (1633_CR148) 2020; 30
EC Wall (1633_CR200) 2021; 397
X-L Yang (1633_CR52) 2016; 90
K Wu (1633_CR209) 2021
1633_CR336
D Hamre (1633_CR307) 1966; 121
M Eaaswarkhanth (1633_CR110) 2020; 96
L van Dorp (1633_CR74) 2020; 83
AP West (1633_CR185) 2021
S Pfefferle (1633_CR21) 2009; 15
RAM Fouchier (1633_CR310) 2004; 101
J Mu (1633_CR145) 2020; 63
KG Andersen (1633_CR38) 2020; 26
EM Cottam (1633_CR128) 2014; 10
Y Guan (1633_CR313) 2003; 302
AM Zaki (1633_CR299) 2012; 367
A Singh (1633_CR222) 2020; 11
1633_CR245
1633_CR243
1633_CR244
MF Boni (1633_CR295) 2020; 5
J-Y Li (1633_CR144) 2020; 286
VM Corman (1633_CR61) 2018; 100
AM Krieg (1633_CR49) 2000; 12
A Sharma (1633_CR247) 2021; 1
Z Wang (1633_CR214) 2021
NAD Bascos (1633_CR164) 2021
ASMRU Alam (1633_CR98) 2021
IV Polozov (1633_CR237) 2008; 4
X Tang (1633_CR73) 2020; 7
MA AlBalwi (1633_CR291) 2020; 13
J-S Lee (1633_CR284) 2020
P Simmonds (1633_CR75) 2020; 5
A Banerjee (1633_CR59) 2020; 36
M Galanti (1633_CR254) 2020; 223
M Thoms (1633_CR320) 2020; 369
C Castaño-Rodriguez (1633_CR338) 2018; 9
Q-X Long (1633_CR257) 2020; 26
Y Wang (1633_CR88) 2020; 9
TT-Y Lam (1633_CR41) 2020; 583
SKP Lau (1633_CR318) 2021; 6
OTR Toovey (1633_CR191) 2021; 82
R Lu (1633_CR14) 2020; 395
RS Baric (1633_CR70) 1990; 177
AHM Wong (1633_CR151) 2017; 8
DJ Becker (1633_CR54) 2020
PP Singh Tomar (1633_CR339) 2020; 530
References_xml – year: 2021
  ident: 1633_CR214
  publication-title: bioRxiv
  doi: 10.1101/2021.01.15.426911
– volume: 181
  start-page: 1489
  issue: 7
  year: 2020
  ident: 1633_CR265
  publication-title: Cell
  doi: 10.1016/j.cell.2020.05.015
– volume-title: Tracking SARS-CoV-2 variants
  year: 2021
  ident: 1633_CR230
– volume: 16
  start-page: e1008421
  issue: 5
  year: 2020
  ident: 1633_CR45
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1008421
– volume: 100
  start-page: 163
  year: 2018
  ident: 1633_CR61
  publication-title: Adv Virus Res
  doi: 10.1016/bs.aivir.2018.01.001
– ident: 1633_CR244
  doi: 10.2139/ssrn.3556998
– volume: 382
  start-page: 727
  issue: 8
  year: 2020
  ident: 1633_CR294
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2001017
– volume: 81
  start-page: 4012
  issue: 8
  year: 2007
  ident: 1633_CR22
  publication-title: J Virol
  doi: 10.1128/JVI.02605-06
– volume: 13
  start-page: 87
  issue: 1
  year: 2016
  ident: 1633_CR25
  publication-title: Virol J
  doi: 10.1186/s12985-016-0544-0
– volume: 370
  start-page: 1464
  issue: 6523
  year: 2020
  ident: 1633_CR107
  publication-title: Science
  doi: 10.1126/science.abe8499
– year: 2021
  ident: 1633_CR185
  publication-title: Bioinformatics
  doi: 10.1101/2021.02.14.431043
– ident: 1633_CR211
– volume: 8
  start-page: 1735
  issue: 1
  year: 2017
  ident: 1633_CR151
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-01706-x
– year: 2021
  ident: 1633_CR77
  publication-title: Infect Dis
  doi: 10.1101/2020.12.30.20249034
– ident: 1633_CR93
– ident: 1633_CR183
– volume: 93
  start-page: 300
  issue: 1
  year: 2021
  ident: 1633_CR119
  publication-title: J Med Virol
  doi: 10.1002/jmv.26264
– year: 2021
  ident: 1633_CR164
  publication-title: Biophysics
  doi: 10.1101/2021.03.06.434059
– ident: 1633_CR243
  doi: 10.2139/ssrn.3550308
– volume: 526
  start-page: 165
  issue: 1
  year: 2020
  ident: 1633_CR175
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2020.03.047
– volume: 93
  start-page: 1908
  issue: 9
  year: 2012
  ident: 1633_CR293
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.043117-0
– volume: 14
  start-page: 239
  issue: 1
  year: 2017
  ident: 1633_CR305
  publication-title: Virol J
  doi: 10.1186/s12985-017-0907-1
– volume: 92
  start-page: 688
  issue: 6
  year: 2020
  ident: 1633_CR126
  publication-title: J Med Virol
  doi: 10.1002/jmv.25758
– volume: 94
  start-page: e00127
  issue: 7
  year: 2020
  ident: 1633_CR159
  publication-title: J Virol
  doi: 10.1128/JVI.00127-20
– year: 2021
  ident: 1633_CR216
  publication-title: Infect Dis
  doi: 10.1101/2021.02.12.21251658
– volume: 9
  start-page: e01985
  issue: 5
  year: 2018
  ident: 1633_CR17
  publication-title: MBio
  doi: 10.1128/mBio.01985-18
– volume: 5
  start-page: 1408
  issue: 11
  year: 2020
  ident: 1633_CR295
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-020-0771-4
– volume: 96
  start-page: 459
  year: 2020
  ident: 1633_CR110
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2020.05.071
– year: 2021
  ident: 1633_CR285
  publication-title: Oral Dis
  doi: 10.1111/odi.13447
– volume: 89
  start-page: 11820
  issue: 23
  year: 2015
  ident: 1633_CR341
  publication-title: J Virol
  doi: 10.1128/JVI.02274-15
– year: 2021
  ident: 1633_CR210
  publication-title: Microbiology
  doi: 10.1101/2021.06.28.449914
– volume: 3
  start-page: 355
  issue: 8
  year: 2020
  ident: 1633_CR224
  publication-title: Vaccines
  doi: 10.3390/vaccines8030355
– volume: 117
  start-page: 15193
  issue: 26
  year: 2020
  ident: 1633_CR58
  publication-title: PNAS
  doi: 10.1073/pnas.2008176117
– volume: 21
  start-page: 356
  issue: 3
  year: 2017
  ident: 1633_CR278
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.02.008
– volume: 88
  start-page: 11297
  issue: 19
  year: 2014
  ident: 1633_CR282
  publication-title: J Virol
  doi: 10.1128/JVI.01498-14
– volume: 19
  start-page: 1697
  issue: 10
  year: 2013
  ident: 1633_CR300
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid1910.130946
– ident: 1633_CR297
– volume: 8
  start-page: S9
  issue: s1
  year: 2003
  ident: 1633_CR9
  publication-title: Respirology
  doi: 10.1046/j.1440-1843.2003.00518.x
– volume: 25
  start-page: 2333
  issue: 12
  year: 2019
  ident: 1633_CR27
  publication-title: Emerg Infect Dis J
  doi: 10.3201/eid2512.190882
– volume: 5
  start-page: 14480
  issue: 1
  year: 2015
  ident: 1633_CR220
  publication-title: Sci Rep
  doi: 10.1038/srep14480
– volume: 93
  start-page: 2387
  issue: 11
  year: 2012
  ident: 1633_CR86
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.044628-0
– volume: 5
  start-page: 1598
  issue: 12
  year: 2020
  ident: 1633_CR259
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-020-00813-8
– volume: 26
  start-page: 1200
  issue: 8
  year: 2020
  ident: 1633_CR257
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0965-6
– volume: 100
  start-page: 216
  year: 2020
  ident: 1633_CR95
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2020.08.052
– volume: 79
  start-page: 15189
  issue: 24
  year: 2005
  ident: 1633_CR322
  publication-title: J Virol
  doi: 10.1128/JVI.79.24.15189-15198.2005
– volume: 143
  start-page: 1110
  issue: 6
  year: 2015
  ident: 1633_CR238
  publication-title: Epidemiol Infect
  doi: 10.1017/S0950268814002702
– volume-title: Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome
  year: 2020
  ident: 1633_CR319
– year: 2020
  ident: 1633_CR122
  publication-title: medRxiv
  doi: 10.1101/2020.08.23.20180281
– ident: 1633_CR194
– volume: 183
  start-page: 739
  issue: 3
  year: 2020
  ident: 1633_CR112
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.032
– year: 2021
  ident: 1633_CR225
  publication-title: Infect Dis
  doi: 10.1101/2021.02.08.21251393
– volume: 83
  start-page: 10314
  issue: 19
  year: 2009
  ident: 1633_CR321
  publication-title: J Virol
  doi: 10.1128/JVI.00842-09
– volume: 587
  start-page: 657
  issue: 7835
  year: 2020
  ident: 1633_CR323
  publication-title: Nature
  doi: 10.1038/s41586-020-2601-5
– volume: 583
  start-page: 286
  issue: 7815
  year: 2020
  ident: 1633_CR42
  publication-title: Nature
  doi: 10.1038/s41586-020-2313-x
– volume: 63
  start-page: 461
  issue: 3
  year: 2020
  ident: 1633_CR18
  publication-title: Sci China Life Sci
  doi: 10.1007/s11427-020-1645-7
– volume: 507
  start-page: 1
  year: 2017
  ident: 1633_CR51
  publication-title: Virology
  doi: 10.1016/j.virol.2017.03.019
– volume: 79
  start-page: 884
  issue: 2
  year: 2005
  ident: 1633_CR279
  publication-title: J Virol
  doi: 10.1128/JVI.79.2.884-895.2005
– volume: 397
  start-page: 452
  issue: 10273
  year: 2021
  ident: 1633_CR186
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)00183-5
– volume: 28
  start-page: 1417
  issue: 2
  year: 2021
  ident: 1633_CR57
  publication-title: Saudi J Biol Sci
  doi: 10.1016/j.sjbs.2020.11.077
– ident: 1633_CR204
– year: 2021
  ident: 1633_CR226
  publication-title: Epidemiology
  doi: 10.1101/2021.05.04.21256637
– volume: 30
  start-page: R849
  issue: 15
  year: 2020
  ident: 1633_CR36
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2020.06.031
– volume: 27
  start-page: 73
  issue: 1
  year: 2020
  ident: 1633_CR135
  publication-title: J Biomed Sci
  doi: 10.1186/s12929-020-00665-8
– volume: 1
  start-page: 343
  issue: 534
  year: 2021
  ident: 1633_CR247
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2020.11.080
– volume: 19
  start-page: 1819
  issue: 11
  year: 2013
  ident: 1633_CR301
  publication-title: Emerg Infect Dis J.
  doi: 10.3201/eid1911.131172
– year: 2021
  ident: 1633_CR158
  publication-title: Genomics
  doi: 10.1101/2021.01.12.426407
– volume: 12
  start-page: 35
  issue: 1
  year: 2000
  ident: 1633_CR49
  publication-title: Curr Opin Immunol
  doi: 10.1016/S0952-7915(99)00048-5
– volume: 105
  start-page: 435
  issue: 2
  year: 1990
  ident: 1633_CR255
  publication-title: Epidemiol Infect
  doi: 10.1017/S0950268800048019
– volume: 67
  start-page: 130
  issue: 2
  year: 2013
  ident: 1633_CR262
  publication-title: J Infect
  doi: 10.1016/j.jinf.2013.03.015
– volume: 159
  start-page: 63
  year: 2018
  ident: 1633_CR16
  publication-title: Antivir Res
  doi: 10.1016/j.antiviral.2018.09.009
– ident: 1633_CR212
– ident: 1633_CR336
  doi: 10.1038/s41420-019-0181-7
– start-page: 1
  volume-title: Brief report: new variant strain of SARS-CoV-2 identified in travelers from Brazil
  year: 2021
  ident: 1633_CR189
– volume: 382
  start-page: 2158
  issue: 22
  year: 2020
  ident: 1633_CR274
  publication-title: N Engl J Med
  doi: 10.1056/NEJMe2009758
– volume: 96
  start-page: 59
  year: 2016
  ident: 1633_CR328
  publication-title: Adv Virus Res
  doi: 10.1016/bs.aivir.2016.08.008
– year: 2020
  ident: 1633_CR34
  publication-title: bioRxiv
  doi: 10.1101/2020.03.02.974139
– volume: 4
  start-page: 3689
  issue: 12
  year: 2012
  ident: 1633_CR56
  publication-title: Viruses
  doi: 10.3390/v4123689
– volume: 5
  start-page: e00266
  issue: 3
  year: 2020
  ident: 1633_CR133
  publication-title: mSystems
  doi: 10.1128/mSystems.00266-20
– volume: 4
  start-page: 248
  issue: 4
  year: 2008
  ident: 1633_CR237
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.77
– volume: 2
  start-page: 1804
  issue: 8
  year: 2010
  ident: 1633_CR67
  publication-title: Viruses
  doi: 10.3390/v2081803
– ident: 1633_CR130
– volume: 9
  start-page: e02325
  issue: 3
  year: 2018
  ident: 1633_CR338
  publication-title: MBio
  doi: 10.1128/mBio.02325-17
– volume: 87
  start-page: 1203
  issue: 5
  year: 2006
  ident: 1633_CR83
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.81662-0
– volume: 5
  start-page: 1
  issue: 1
  year: 2020
  ident: 1633_CR165
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-019-0089-y
– year: 2021
  ident: 1633_CR203
  publication-title: Microbiology
  doi: 10.1101/2021.05.28.446163
– volume: 194
  start-page: 191
  year: 2014
  ident: 1633_CR332
  publication-title: Virus Res
  doi: 10.1016/j.virusres.2014.09.009
– volume: 190
  start-page: 92
  issue: 1
  year: 1992
  ident: 1633_CR69
  publication-title: Virology
  doi: 10.1016/0042-6822(92)91195-Z
– volume: 93
  start-page: 2132
  issue: 4
  year: 2020
  ident: 1633_CR132
  publication-title: J Med Virol
  doi: 10.1002/jmv.26597
– volume: 367
  start-page: 1814
  issue: 19
  year: 2012
  ident: 1633_CR299
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1211721
– volume: 182
  start-page: 812
  issue: 4
  year: 2020
  ident: 1633_CR104
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.043
– volume: 591
  start-page: 639
  year: 2021
  ident: 1633_CR179
  publication-title: Nature
  doi: 10.1038/s41586-021-03207-w
– volume: 217
  start-page: 1728
  issue: 11
  year: 2018
  ident: 1633_CR85
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy098
– volume: 18
  start-page: 20662
  issue: 50
  year: 2013
  ident: 1633_CR28
  publication-title: Eurosurveillance
  doi: 10.2807/1560-7917.ES2013.18.50.20662
– volume: 5
  start-page: e00408
  issue: 3
  year: 2020
  ident: 1633_CR75
  publication-title: mSphere
  doi: 10.1128/mSphere.00408-20
– volume: 100
  start-page: 112
  year: 2020
  ident: 1633_CR273
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2020.08.076
– volume: 10
  start-page: 1813
  year: 2019
  ident: 1633_CR330
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2019.01813
– volume: 4
  start-page: 26
  issue: 4
  year: 2016
  ident: 1633_CR12
  publication-title: Diseases
  doi: 10.3390/diseases4030026
– volume: 6
  start-page: 21878
  issue: 1
  year: 2016
  ident: 1633_CR24
  publication-title: Sci Rep
  doi: 10.1038/srep21878
– volume: 17
  start-page: e1009619
  issue: 6
  year: 2021
  ident: 1633_CR228
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1009619
– volume: 286
  start-page: 198074
  year: 2020
  ident: 1633_CR144
  publication-title: Virus Res
  doi: 10.1016/j.virusres.2020.198074
– ident: 1633_CR170
– volume: 166
  start-page: 801
  issue: 3
  year: 2021
  ident: 1633_CR218
  publication-title: Arch Virol
  doi: 10.1007/s00705-020-04911-0
– volume-title: Risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA—first update
  year: 2021
  ident: 1633_CR190
– volume: 10
  start-page: 17002
  issue: 1
  year: 2020
  ident: 1633_CR251
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-74089-7
– year: 2020
  ident: 1633_CR192
  publication-title: Genet Genomic Med
  doi: 10.1101/2020.12.23.20248598
– volume: 20
  start-page: e238
  issue: 9
  year: 2020
  ident: 1633_CR249
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(20)30484-9
– volume: 78
  start-page: 779
  issue: 4
  year: 2020
  ident: 1633_CR166
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2020.04.022
– volume: 82
  start-page: 11318
  issue: 22
  year: 2008
  ident: 1633_CR143
  publication-title: J Virol
  doi: 10.1128/JVI.01052-08
– year: 2021
  ident: 1633_CR177
  publication-title: bioRxiv
  doi: 10.1101/2021.01.10.426143
– volume: 16
  start-page: 1686
  issue: 10
  year: 2020
  ident: 1633_CR275
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.45472
– volume: 587
  start-page: 270
  issue: 7833
  year: 2020
  ident: 1633_CR268
  publication-title: Nature
  doi: 10.1038/s41586-020-2598-9
– volume: 118
  start-page: e2021785118
  issue: 2
  year: 2021
  ident: 1633_CR137
  publication-title: PNAS
  doi: 10.1073/pnas.2021785118
– volume: 10
  start-page: 16862
  issue: 1
  year: 2020
  ident: 1633_CR174
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-73820-8
– volume: 11
  start-page: 101
  issue: 3
  year: 2020
  ident: 1633_CR217
  publication-title: Osong Public Health Res Perspect
  doi: 10.24171/j.phrp.2020.11.3.05
– volume: 17
  start-page: 181
  issue: 3
  year: 2019
  ident: 1633_CR3
  publication-title: Nat Rev Microbiol
  doi: 10.1038/s41579-018-0118-9
– volume: 9
  start-page: 2399
  issue: 8
  year: 2020
  ident: 1633_CR118
  publication-title: JCM
  doi: 10.3390/jcm9082399
– year: 2020
  ident: 1633_CR325
  publication-title: Bioinformatics
  doi: 10.1101/2020.05.23.104919
– ident: 1633_CR171
– volume: 9
  start-page: e61312
  year: 2020
  ident: 1633_CR91
  publication-title: Elife
  doi: 10.7554/eLife.61312
– volume: 89
  start-page: 10532
  issue: 20
  year: 2015
  ident: 1633_CR140
  publication-title: J Virol
  doi: 10.1128/JVI.01048-15
– volume: 223
  start-page: 409
  year: 2020
  ident: 1633_CR254
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiaa392
– start-page: 93
  volume-title: Advances in virus research. Complementary strategies to understand virus structure and function
  year: 2019
  ident: 1633_CR82
  doi: 10.1016/bs.aivir.2019.08.002
– volume: 510
  start-page: 165
  year: 2017
  ident: 1633_CR324
  publication-title: Virology
  doi: 10.1016/j.virol.2017.07.019
– volume: 182
  start-page: 1284
  issue: 5
  year: 2020
  ident: 1633_CR198
  publication-title: Cell
  doi: 10.1016/j.cell.2020.07.012
– volume: 13
  start-page: 1544
  issue: 10
  year: 2020
  ident: 1633_CR291
  publication-title: J Infect Public Health
  doi: 10.1016/j.jiph.2020.06.030
– volume: 222
  start-page: 719
  issue: 5
  year: 2020
  ident: 1633_CR234
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiaa345
– year: 2020
  ident: 1633_CR39
  publication-title: bioRxiv
  doi: 10.1101/2020.02.07.939207
– volume: 27
  start-page: 1522
  year: 2021
  ident: 1633_CR193
  publication-title: Life Sci
– volume: 5
  start-page: 52
  year: 2020
  ident: 1633_CR253
  publication-title: Wellcome Open Res
  doi: 10.12688/wellcomeopenres.15812.2
– volume: 22
  start-page: 49
  issue: 1
  year: 2016
  ident: 1633_CR26
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2201.151340
– volume: 181
  start-page: 223
  issue: 2
  year: 2020
  ident: 1633_CR35
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.035
– volume: 395
  start-page: 565
  issue: 10224
  year: 2020
  ident: 1633_CR14
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30251-8
– year: 2020
  ident: 1633_CR113
  publication-title: medRxiv
  doi: 10.1101/2020.07.22.20159905
– year: 2021
  ident: 1633_CR176
  publication-title: bioRxiv.
  doi: 10.1101/2021.01.13.426558
– year: 2020
  ident: 1633_CR335
  publication-title: bioRxiv.
  doi: 10.1101/2020.10.27.357731
– volume: 11
  start-page: 4646
  issue: 1
  year: 2020
  ident: 1633_CR292
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-18440-6
– volume: 90
  start-page: 3627
  issue: 7
  year: 2016
  ident: 1633_CR290
  publication-title: J Virol
  doi: 10.1128/JVI.02988-15
– volume: 113
  start-page: 9864
  issue: 35
  year: 2016
  ident: 1633_CR55
  publication-title: PNAS
  doi: 10.1073/pnas.1604472113
– volume: 14
  start-page: 3
  issue: 1
  year: 2020
  ident: 1633_CR29
  publication-title: J Infect Dev Ctries
  doi: 10.3855/jidc.12425
– year: 2016
  ident: 1633_CR131
  publication-title: Virus Evol
  doi: 10.1093/ve/vev023
– volume: 102
  start-page: 2430
  issue: 7
  year: 2005
  ident: 1633_CR314
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0409608102
– volume: 19
  start-page: e3001236
  issue: 5
  year: 2021
  ident: 1633_CR195
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3001236
– volume: 5
  start-page: e01062
  issue: 1
  year: 2014
  ident: 1633_CR288
  publication-title: MBio
  doi: 10.1128/mBio.01062-13
– volume: 7
  start-page: e00019
  issue: 2
  year: 2016
  ident: 1633_CR152
  publication-title: MBio
  doi: 10.1128/mBio.00019-16
– year: 2021
  ident: 1633_CR215
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2108891
– volume: 325
  start-page: 1
  year: 2020
  ident: 1633_CR106
  publication-title: Nature
– start-page: 435
  volume-title: Fenner’s veterinary virology
  year: 2017
  ident: 1633_CR6
– volume: 368
  start-page: 860
  issue: 6493
  year: 2020
  ident: 1633_CR233
  publication-title: Science
  doi: 10.1126/science.abb5793
– volume: 9
  start-page: 929
  issue: 1
  year: 2019
  ident: 1633_CR236
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-37481-y
– year: 2021
  ident: 1633_CR229
  publication-title: Immunology
  doi: 10.1101/2021.03.31.437925
– volume: 8
  start-page: 100043
  year: 2020
  ident: 1633_CR46
  publication-title: Med Nov Technol Devices
  doi: 10.1016/j.medntd.2020.100043
– volume: 10
  start-page: 368
  issue: 4
  year: 2004
  ident: 1633_CR309
  publication-title: Nat Med
  doi: 10.1038/nm1024
– volume: 181
  start-page: 281
  issue: 2
  year: 2020
  ident: 1633_CR333
  publication-title: Cell
  doi: 10.1016/j.cell.2020.02.058
– volume: 530
  start-page: 10
  issue: 1
  year: 2020
  ident: 1633_CR339
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2020.05.206
– volume: 116
  start-page: 10905
  issue: 22
  year: 2019
  ident: 1633_CR242
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1902840116
– volume: 5
  start-page: 11451
  issue: 1
  year: 2015
  ident: 1633_CR84
  publication-title: Sci Rep
  doi: 10.1038/srep11451
– volume: 325
  start-page: 529
  year: 2021
  ident: 1633_CR105
  publication-title: JAMA
  doi: 10.1001/jama.2020.27124
– volume: 579
  start-page: 270
  issue: 7798
  year: 2020
  ident: 1633_CR32
  publication-title: Nature
  doi: 10.1038/s41586-020-2012-7
– volume: 12
  start-page: 972
  issue: 1
  year: 2021
  ident: 1633_CR40
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21240-1
– volume: 348
  start-page: 1967
  issue: 20
  year: 2003
  ident: 1633_CR298
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa030747
– volume: 36
  start-page: 180
  year: 2020
  ident: 1633_CR59
  publication-title: Trends Ecol Evol
  doi: 10.1016/j.tree.2020.12.002
– volume: 11
  start-page: 610688
  year: 2020
  ident: 1633_CR256
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.610688/full#B23
– volume: 78
  start-page: 8824
  issue: 16
  year: 2004
  ident: 1633_CR277
  publication-title: J Virol
  doi: 10.1128/JVI.78.16.8824-8834.2004
– year: 2020
  ident: 1633_CR108
  publication-title: bioRxiv
  doi: 10.1101/2020.07.26.219741
– volume: 12
  start-page: 780
  issue: 1
  year: 2021
  ident: 1633_CR271
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21034-5
– volume: 16
  start-page: 117693432096514
  year: 2020
  ident: 1633_CR123
  publication-title: Evol Bioinform Online
  doi: 10.1177/1176934320965149
– volume: 105
  start-page: 121
  issue: 2
  year: 2004
  ident: 1633_CR141
  publication-title: Virus Res
  doi: 10.1016/j.virusres.2004.05.002
– year: 2020
  ident: 1633_CR92
  publication-title: medRxiv.
  doi: 10.1101/2020.12.05.20241927
– volume-title: Rapid increase of a SARS-CoV-2 variant with multiple spike protein mutations observed in the United Kingdom
  year: 2020
  ident: 1633_CR99
– volume: 13
  start-page: e1006698
  issue: 11
  year: 2017
  ident: 1633_CR280
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006698
– volume: 22
  start-page: 30494
  issue: 13
  year: 2017
  ident: 1633_CR102
  publication-title: Euro Surveill
  doi: 10.2807/1560-7917.ES.2017.22.13.30494
– volume: 141
  start-page: 96
  issue: 1
  year: 2009
  ident: 1633_CR64
  publication-title: Virus Res
  doi: 10.1016/j.virusres.2008.12.011
– volume: 364
  start-page: 964
  issue: 5
  year: 2006
  ident: 1633_CR87
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2006.09.074
– volume: 588
  start-page: 682
  issue: 7839
  year: 2020
  ident: 1633_CR181
  publication-title: Nature
  doi: 10.1038/s41586-020-2852-1
– volume: 556
  start-page: 255
  issue: 7700
  year: 2018
  ident: 1633_CR5
  publication-title: Nature
  doi: 10.1038/s41586-018-0010-9
– volume: 369
  start-page: 1249
  issue: 6508
  year: 2020
  ident: 1633_CR320
  publication-title: Science
  doi: 10.1126/science.abc8665
– year: 2021
  ident: 1633_CR160
  publication-title: bioRxiv.
  doi: 10.1101/2020.12.29.424708
– year: 2020
  ident: 1633_CR147
  publication-title: medRxiv.
  doi: 10.1101/2020.11.28.20237016
– volume: 86
  start-page: 3995
  issue: 7
  year: 2012
  ident: 1633_CR2
  publication-title: J Virol
  doi: 10.1128/JVI.06540-11
– volume: 79
  start-page: 3223
  issue: 5
  year: 2005
  ident: 1633_CR68
  publication-title: J Virol
  doi: 10.1128/JVI.79.5.3223-3225.2005
– year: 2021
  ident: 1633_CR221
  publication-title: Bioinformatics
  doi: 10.1101/2021.01.25.427846
– ident: 1633_CR245
  doi: 10.2139/ssrn.3551767
– volume: 5
  start-page: 89
  issue: 1
  year: 2020
  ident: 1633_CR7
  publication-title: Sig Transduct Target Ther
  doi: 10.1038/s41392-020-0190-2
– volume: 5
  start-page: 1403
  issue: 11
  year: 2020
  ident: 1633_CR347
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-020-0770-5
– volume-title: Global phylogeny updated by NextStrain
  year: 2021
  ident: 1633_CR97
– volume: 22
  start-page: 1695
  issue: 4
  year: 2021
  ident: 1633_CR188
  publication-title: IJMS.
  doi: 10.3390/ijms22041695
– ident: 1633_CR202
  doi: 10.1038/s41586-021-03777-9
– volume: 384
  start-page: 1466
  year: 2021
  ident: 1633_CR208
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc2102017
– volume: 369
  start-page: 77
  issue: 6499
  year: 2020
  ident: 1633_CR269
  publication-title: Science
  doi: 10.1126/science.abc1932
– volume: 10
  start-page: 4481
  issue: 1
  year: 2020
  ident: 1633_CR329
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-61432-1
– year: 2021
  ident: 1633_CR184
  publication-title: Evol Biol
  doi: 10.1101/2021.01.27.426895
– year: 2020
  ident: 1633_CR223
  publication-title: Infect Dis
  doi: 10.1101/2020.12.19.20248567
– volume: 101
  start-page: 791
  issue: 8
  year: 2020
  ident: 1633_CR264
  publication-title: J Gen Virol
  doi: 10.1099/jgv.0.001439
– year: 2021
  ident: 1633_CR196
  publication-title: Mol Biol
  doi: 10.1101/2021.04.22.440932
– volume: 63
  start-page: 1
  issue: 9
  year: 2020
  ident: 1633_CR145
  publication-title: Sci China Life Sci
  doi: 10.1007/s11427-020-1692-1
– volume: 117
  start-page: 9490
  issue: 17
  year: 2020
  ident: 1633_CR270
  publication-title: PNAS
  doi: 10.1073/pnas.2004168117
– year: 2021
  ident: 1633_CR227
  publication-title: Microbiology
  doi: 10.1101/2021.04.30.441434
– volume: 83
  start-page: 104351
  year: 2020
  ident: 1633_CR74
  publication-title: Infect Genet Evol
  doi: 10.1016/j.meegid.2020.104351
– year: 2021
  ident: 1633_CR209
  publication-title: bioRxiv
  doi: 10.1101/2021.01.25.427948
– volume: 121
  start-page: 190
  issue: 1
  year: 1966
  ident: 1633_CR307
  publication-title: Proc Soc Exp Biol Med
  doi: 10.3181/00379727-121-30734
– year: 2021
  ident: 1633_CR178
  publication-title: bioRxiv
  doi: 10.1101/2020.11.06.372037
– volume: 27
  start-page: 1
  year: 2021
  ident: 1633_CR213
  publication-title: Nat Med
  doi: 10.1038/s41591-021-01270-4
– volume: 302
  start-page: 276
  issue: 5643
  year: 2003
  ident: 1633_CR313
  publication-title: Science
  doi: 10.1126/science.1087139
– volume: 6
  start-page: 131
  issue: 1
  year: 2009
  ident: 1633_CR342
  publication-title: Virol J
  doi: 10.1186/1743-422X-6-131
– year: 2021
  ident: 1633_CR201
  publication-title: Microbiology
  doi: 10.1101/2021.05.08.443253
– volume: 583
  start-page: 459
  issue: 7816
  year: 2020
  ident: 1633_CR345
  publication-title: Nature
  doi: 10.1038/s41586-020-2286-9
– volume: 303
  start-page: 1666
  issue: 5664
  year: 2004
  ident: 1633_CR138
  publication-title: Science
  doi: 10.1126/science.1092002
– ident: 1633_CR78
  doi: 10.1101/2020.12.14.422555
– year: 2020
  ident: 1633_CR149
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa1275ciaa1275
– volume: 92
  start-page: 522
  issue: 5
  year: 2020
  ident: 1633_CR96
  publication-title: J Med Virol
  doi: 10.1002/jmv.25700
– year: 2021
  ident: 1633_CR206
  publication-title: medRxiv.
  doi: 10.1101/2021.02.02.21250799
– volume: 82
  start-page: e23
  year: 2021
  ident: 1633_CR191
  publication-title: J Infect
  doi: 10.1016/j.jinf.2021.01.025
– volume: 351
  start-page: 81
  issue: 6268
  year: 2016
  ident: 1633_CR60
  publication-title: Science
  doi: 10.1126/science.aac8608
– volume: 27
  start-page: 325
  year: 2020
  ident: 1633_CR344
  publication-title: bioRxiv
– volume: 20
  start-page: 533
  issue: 5
  year: 2020
  ident: 1633_CR248
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(20)30120-1
– ident: 1633_CR89
– ident: 1633_CR146
– year: 2021
  ident: 1633_CR163
  publication-title: Immunology
  doi: 10.1101/2021.01.14.426475
– volume: 18
  start-page: 179
  year: 2020
  ident: 1633_CR121
  publication-title: J Transl Med
  doi: 10.1186/s12967-020-02344-6
– volume: 29
  start-page: 44
  issue: 1
  year: 2021
  ident: 1633_CR154
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2020.11.007
– volume: 538
  start-page: 116
  year: 2020
  ident: 1633_CR169
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2020.10.045
– year: 2020
  ident: 1633_CR167
  publication-title: bioRxiv
  doi: 10.1101/2020.09.30.318311
– volume: 58
  start-page: 540
  issue: 3
  year: 2020
  ident: 1633_CR44
  publication-title: Afr J Ecol
  doi: 10.1111/aje.12759
– year: 2021
  ident: 1633_CR173
  publication-title: medRxiv
  doi: 10.1101/2021.01.19.21249840
– volume: 122
  start-page: 183
  issue: 2
  year: 2002
  ident: 1633_CR241
  publication-title: Acta Otolaryngol
  doi: 10.1080/00016480252814207
– volume: 26
  start-page: 1470
  issue: 7
  year: 2020
  ident: 1633_CR250
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2607.200282
– volume: 29
  start-page: 503
  year: 2021
  ident: 1633_CR156
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.02.017
– year: 2021
  ident: 1633_CR161
  publication-title: Epidemiology
  doi: 10.1101/2020.12.28.20248906
– volume: 57
  start-page: 933
  issue: 4
  year: 1967
  ident: 1633_CR306
  publication-title: PNAS
  doi: 10.1073/pnas.57.4.933
– volume: 17
  start-page: 330
  issue: 6
  year: 2006
  ident: 1633_CR263
  publication-title: Can J Infect Dis Med Microbiol
  doi: 10.1155/2006/152612
– volume: 21
  start-page: 1508
  year: 2015
  ident: 1633_CR31
  publication-title: Nat Med
  doi: 10.1038/nm.3985
– volume: 15
  start-page: e0240079
  issue: 10
  year: 2020
  ident: 1633_CR327
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0240079
– volume: 12
  start-page: 651
  issue: 4 Pt B
  year: 2007
  ident: 1633_CR8
  publication-title: Antivir Ther (Lond).
  doi: 10.1177/135965350701200S01.1
– volume: 26
  start-page: 1
  year: 2020
  ident: 1633_CR38
  publication-title: Nat Med
  doi: 10.1038/s41591-020-0820-9
– volume: 182
  start-page: 1295
  issue: 5
  year: 2020
  ident: 1633_CR311
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.012
– volume: 2
  start-page: 387
  issue: 5
  year: 2001
  ident: 1633_CR80
  publication-title: Nat Rev Genet
  doi: 10.1038/35072023
– volume: 11
  start-page: 580137
  year: 2020
  ident: 1633_CR47
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2020.580137/full
– volume: 17
  start-page: 765
  issue: 7
  year: 2020
  ident: 1633_CR219
  publication-title: Cell Mol Immunol
  doi: 10.1038/s41423-020-0374-2
– volume: 194
  start-page: 808
  issue: 6
  year: 2006
  ident: 1633_CR312
  publication-title: J Infect Dis
  doi: 10.1086/507044
– volume: 372
  start-page: n359
  year: 2021
  ident: 1633_CR172
  publication-title: BMJ
  doi: 10.1136/bmj.n359
– year: 2020
  ident: 1633_CR90
  publication-title: bioRxiv.
  doi: 10.1101/2020.11.19.389916
– volume: 370
  start-page: 89
  issue: 6512
  year: 2020
  ident: 1633_CR266
  publication-title: Science
  doi: 10.1126/science.abd3871
– volume: 145
  start-page: 110330
  year: 2020
  ident: 1633_CR48
  publication-title: Med Hypotheses
  doi: 10.1016/j.mehy.2020.110330
– volume: 40
  start-page: 1289
  issue: 8
  year: 2017
  ident: 1633_CR50
  publication-title: Biol Pharm Bull
  doi: 10.1248/bpb.b17-00241
– volume: 86
  start-page: 12816
  issue: 23
  year: 2012
  ident: 1633_CR308
  publication-title: J Virol
  doi: 10.1128/JVI.00906-12
– volume: 383
  start-page: 1085
  issue: 11
  year: 2020
  ident: 1633_CR258
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc2025179
– volume: 183
  start-page: 1024
  issue: 4
  year: 2020
  ident: 1633_CR155
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.037
– volume: 11
  start-page: 550674
  year: 2020
  ident: 1633_CR124
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2020.550674
– volume: 395
  start-page: 1063
  issue: 10229
  year: 2020
  ident: 1633_CR10
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)33221-0
– start-page: 193
  volume-title: Advances in virus research
  year: 2006
  ident: 1633_CR142
  doi: 10.1016/S0065-3527(06)66005-3
– volume: 33
  start-page: 108234
  issue: 1
  year: 2020
  ident: 1633_CR127
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2020.108234
– year: 2020
  ident: 1633_CR187
  publication-title: Mol Biol
  doi: 10.1101/2020.12.23.424283
– volume: 6
  start-page: e00819
  issue: 1
  year: 2021
  ident: 1633_CR318
  publication-title: mSphere.
  doi: 10.1128/mSphere.00819-20
– volume: 72
  start-page: 672
  issue: 4
  year: 2008
  ident: 1633_CR19
  publication-title: MMBR
  doi: 10.1128/MMBR.00015-08
– volume: 19
  start-page: 456
  issue: 3
  year: 2013
  ident: 1633_CR304
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid1903.121503
– volume: 49
  start-page: 1311
  issue: 12
  year: 2004
  ident: 1633_CR315
  publication-title: Chin Sci Bull
  doi: 10.1360/04wc0153
– volume: 9
  start-page: 246
  issue: 1
  year: 2020
  ident: 1633_CR88
  publication-title: Emerg Microbes Infect
  doi: 10.1080/22221751.2020.1717999
– volume: 370
  start-page: 527
  issue: 6516
  year: 2020
  ident: 1633_CR261
  publication-title: Science
  doi: 10.1126/science.abe5960
– volume: 30
  start-page: 1346
  issue: 7
  year: 2020
  ident: 1633_CR283
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2020.03.022
– volume: 10
  start-page: e041397
  issue: 11
  year: 2020
  ident: 1633_CR246
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2020-041397
– volume: 503
  start-page: 535
  issue: 7477
  year: 2013
  ident: 1633_CR53
  publication-title: Nature
  doi: 10.1038/nature12711
– volume: 15
  start-page: e0242537
  issue: 11
  year: 2020
  ident: 1633_CR116
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0242537
– volume: 397
  start-page: 2331
  issue: 10292
  year: 2021
  ident: 1633_CR200
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)01290-3
– year: 2021
  ident: 1633_CR231
  publication-title: Epidemiology
  doi: 10.1101/2021.06.26.21259487
– volume: 7
  start-page: 1012
  issue: 6
  year: 2020
  ident: 1633_CR73
  publication-title: Natl Sci Rev
  doi: 10.1093/nsr/nwaa036
– volume: 3
  start-page: 18
  issue: 1
  year: 2005
  ident: 1633_CR286
  publication-title: Genomics Proteomics Bioinf
  doi: 10.1016/S1672-0229(05)03004-4
– volume: 6
  start-page: 79
  year: 2009
  ident: 1633_CR340
  publication-title: Virol J
  doi: 10.1186/1743-422X-6-79
– volume: 12
  start-page: 502
  issue: 5
  year: 2020
  ident: 1633_CR287
  publication-title: Viruses
  doi: 10.3390/v12050502
– year: 2020
  ident: 1633_CR150
  publication-title: medRxiv.
  doi: 10.1101/2020.10.25.20219063
– volume: 101
  start-page: 1251
  issue: 12
  year: 2020
  ident: 1633_CR71
  publication-title: J Gen Virol
  doi: 10.1099/jgv.0.001491
– volume: 222
  start-page: 9
  issue: 1
  year: 2020
  ident: 1633_CR235
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiaa161
– volume: 79
  start-page: 1595
  issue: 3
  year: 2005
  ident: 1633_CR276
  publication-title: JVI
  doi: 10.1128/JVI.79.3.1595-1604.2005
– volume: 21
  start-page: 544
  issue: 10
  year: 2013
  ident: 1633_CR66
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2013.05.005
– year: 2020
  ident: 1633_CR136
  publication-title: bioRxiv
  doi: 10.1101/2020.05.24.111823
– volume: 10
  start-page: 1426
  issue: 8
  year: 2014
  ident: 1633_CR128
  publication-title: Autophagy
  doi: 10.4161/auto.29309
– volume: 25
  start-page: 35
  issue: 1
  year: 2017
  ident: 1633_CR139
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2016.09.001
– volume: 184
  start-page: 1171
  year: 2021
  ident: 1633_CR205
  publication-title: Cell
  doi: 10.1016/j.cell.2021.01.037
– volume: 22
  start-page: 1031
  issue: 6
  year: 2016
  ident: 1633_CR23
  publication-title: Emerg Infect Dis J
  doi: 10.3201/eid2206.160192
– volume: 579
  start-page: 265
  issue: 7798
  year: 2020
  ident: 1633_CR37
  publication-title: Nature
  doi: 10.1038/s41586-020-2008-3
– volume: 74
  start-page: e13525
  issue: 8
  year: 2020
  ident: 1633_CR114
  publication-title: Int J Clin Pract
  doi: 10.1111/ijcp.13525
– volume: 93
  start-page: 5638
  issue: 9
  year: 2021
  ident: 1633_CR199
  publication-title: J Med Virol
  doi: 10.1002/jmv.27062
– volume: 432
  start-page: 5212
  issue: 19
  year: 2020
  ident: 1633_CR157
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2020.07.009
– volume: 27
  start-page: 327
  issue: 1
  year: 2021
  ident: 1633_CR260
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2701.203515
– volume: 21
  start-page: 72
  issue: 1
  year: 2020
  ident: 1633_CR111
  publication-title: Egypt J Med Hum Genet
  doi: 10.1186/s43042-020-00116-x
– ident: 1633_CR101
– volume: 82
  start-page: 12422
  issue: 24
  year: 2008
  ident: 1633_CR65
  publication-title: J Virol
  doi: 10.1128/JVI.01586-08
– volume: 98
  start-page: 495
  issue: 7
  year: 2020
  ident: 1633_CR117
  publication-title: Bull World Health Organ
  doi: 10.2471/BLT.20.253591
– volume: 4
  start-page: e1000304
  issue: 12
  year: 2008
  ident: 1633_CR72
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000304
– volume: 91
  start-page: e01953
  issue: 5
  year: 2017
  ident: 1633_CR20
  publication-title: J Virol
  doi: 10.1128/JVI.01953-16
– volume: 81
  start-page: e24
  issue: 1
  year: 2020
  ident: 1633_CR129
  publication-title: J Infect
  doi: 10.1016/j.jinf.2020.03.058
– volume-title: COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)
  year: 2020
  ident: 1633_CR11
– volume: 11
  start-page: 4320
  year: 2020
  ident: 1633_CR222
  publication-title: Res Square
– volume: 24
  start-page: 490
  issue: 6
  year: 2016
  ident: 1633_CR1
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2016.03.003
– year: 2020
  ident: 1633_CR54
  publication-title: Ecology
  doi: 10.1101/2020.05.22.111344
– year: 2020
  ident: 1633_CR100
  publication-title: Epidemiology
  doi: 10.1101/2020.12.21.20248640
– volume: 59
  start-page: 479
  issue: 4
  year: 1961
  ident: 1633_CR239
  publication-title: J Hyg (Lond)
– volume: 93
  start-page: e01381
  issue: 2
  year: 2019
  ident: 1633_CR317
  publication-title: J Virol
  doi: 10.1128/JVI.01381-18
– volume: 372
  start-page: eabg3055
  issue: 6538
  year: 2021
  ident: 1633_CR79
  publication-title: Science
  doi: 10.1126/science.abg3055
– year: 2021
  ident: 1633_CR272
  publication-title: Evol Biol
  doi: 10.1101/2021.02.03.429646
– volume: 101
  start-page: 6212
  issue: 16
  year: 2004
  ident: 1633_CR310
  publication-title: PNAS
  doi: 10.1073/pnas.0400762101
– volume: 12
  start-page: 837
  year: 2020
  ident: 1633_CR43
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21006-9
– volume: 1
  start-page: 100036
  issue: 3
  year: 2020
  ident: 1633_CR168
  publication-title: CR Med
– year: 2020
  ident: 1633_CR232
  publication-title: Front Public Health
  doi: 10.3389/fpubh.2020.567184/full
– volume: 226
  start-page: 20
  year: 2016
  ident: 1633_CR4
  publication-title: Virus Res
  doi: 10.1016/j.virusres.2016.05.023
– year: 2020
  ident: 1633_CR125
  publication-title: bioRxiv
  doi: 10.1101/2020.12.23.424229
– volume: 15
  start-page: 1377
  issue: 9
  year: 2009
  ident: 1633_CR21
  publication-title: Ghana Emerg Infect Dis
  doi: 10.3201/eid1509.090224
– volume-title: Threat assessment brief: emergence of SARS-CoV-2 B.1.617 variants in India and situation in the EU/EEA
  year: 2021
  ident: 1633_CR346
– volume: 176
  start-page: 104742
  year: 2020
  ident: 1633_CR33
  publication-title: Antivir Res
  doi: 10.1016/j.antiviral.2020.104742
– volume: 177
  start-page: 646
  issue: 2
  year: 1990
  ident: 1633_CR70
  publication-title: Virology
  doi: 10.1016/0042-6822(90)90530-5
– volume: 11
  start-page: 1800
  year: 2020
  ident: 1633_CR94
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2020.01800/full
– volume: 10
  start-page: 766
  issue: 5
  year: 2020
  ident: 1633_CR326
  publication-title: Acta Pharm Sin B
  doi: 10.1016/j.apsb.2020.02.008
– volume: 26
  start-page: 1691
  issue: 11
  year: 2020
  ident: 1633_CR252
  publication-title: Nat Med
  doi: 10.1038/s41591-020-1083-1
– volume: 302
  start-page: 276
  issue: 5643
  year: 2003
  ident: 1633_CR281
  publication-title: Science
  doi: 10.1126/science.1087139
– volume: 280
  start-page: 29588
  issue: 33
  year: 2005
  ident: 1633_CR316
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M500662200
– volume: 98
  start-page: 947
  issue: 7
  year: 2020
  ident: 1633_CR13
  publication-title: J Mol Med
  doi: 10.1007/s00109-020-01931-w
– volume: 17
  start-page: 998
  issue: 9
  year: 2020
  ident: 1633_CR343
  publication-title: Cell Mol Immunol
  doi: 10.1038/s41423-020-0514-8
– volume: 11
  start-page: 41
  issue: 1
  year: 2019
  ident: 1633_CR30
  publication-title: Viruses
  doi: 10.3390/v11010041
– volume: 10
  start-page: 2342
  issue: 1
  year: 2019
  ident: 1633_CR120
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-10280-3
– volume: 24
  start-page: 1634
  issue: 8
  year: 2005
  ident: 1633_CR153
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7600640
– volume: 33
  start-page: 8865
  issue: 8
  year: 2019
  ident: 1633_CR334
  publication-title: FASEB J
  doi: 10.1096/fj.201802418R
– volume: 3
  start-page: 219
  issue: 3
  year: 2003
  ident: 1633_CR62
  publication-title: Infect Genet Evol
  doi: 10.1016/j.meegid.2003.08.001
– year: 2020
  ident: 1633_CR76
  publication-title: medRxiv.
  doi: 10.1101/2020.03.16.20034470
– volume: 30
  start-page: 702
  issue: 8
  year: 2020
  ident: 1633_CR148
  publication-title: Cell Res
  doi: 10.1038/s41422-020-0366-x
– ident: 1633_CR162
– volume: 2
  start-page: FDD42
  issue: 3
  year: 2020
  ident: 1633_CR331
  publication-title: Future Drug Discov.
  doi: 10.4155/fdd-2020-0012
– volume: 1
  start-page: 624
  issue: 6
  year: 2011
  ident: 1633_CR63
  publication-title: Curr Opin Virol
  doi: 10.1016/j.coviro.2011.10.012
– volume: 17
  start-page: 1
  year: 2020
  ident: 1633_CR134
  publication-title: Cell Mol Immunol
  doi: 10.1038/s41423-020-0485-9
– year: 2020
  ident: 1633_CR180
  publication-title: bioRxiv.
  doi: 10.1101/2020.12.28.424451
– volume: 8
  start-page: e00373
  issue: 2
  year: 2017
  ident: 1633_CR302
  publication-title: MBio
  doi: 10.1128/mBio.00373-17
– volume-title: MERS-CoV worldwide overview
  year: 2021
  ident: 1633_CR15
– year: 2021
  ident: 1633_CR197
  publication-title: Microbiology
  doi: 10.1101/2021.04.02.438288
– volume: 213
  start-page: 579
  issue: 4
  year: 2016
  ident: 1633_CR296
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiv476
– year: 2020
  ident: 1633_CR284
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa1421
– volume: 11
  start-page: 6013
  issue: 1
  year: 2020
  ident: 1633_CR103
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-19808-4
– volume: 9
  start-page: 2685
  issue: 1
  year: 2020
  ident: 1633_CR337
  publication-title: Emerg Microbes Infect
  doi: 10.1080/22221751.2020.1852892
– volume: 76
  start-page: 828
  issue: 9
  year: 1998
  ident: 1633_CR240
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/y98-097
– volume: 165
  start-page: 1
  year: 2020
  ident: 1633_CR81
  publication-title: Arch Virol
  doi: 10.1007/s00705-020-04750-z
– year: 2021
  ident: 1633_CR98
  publication-title: Infect Dis
  doi: 10.1101/2021.02.21.21252137
– volume: 371
  start-page: 1152
  year: 2021
  ident: 1633_CR207
  publication-title: Science
  doi: 10.1126/science.abg6105
– volume: 369
  start-page: 1014
  issue: 6506
  year: 2020
  ident: 1633_CR182
  publication-title: Science
  doi: 10.1126/science.abd0831
– volume: 18
  start-page: 2138
  issue: 10
  year: 2017
  ident: 1633_CR289
  publication-title: IJMS
  doi: 10.3390/ijms18102138
– year: 2020
  ident: 1633_CR115
  publication-title: medRxiv
  doi: 10.1101/2020.05.19.20107144
– volume: 584
  start-page: 457
  issue: 7821
  year: 2020
  ident: 1633_CR267
  publication-title: Nature
  doi: 10.1038/s41586-020-2550-z
– volume: 218
  start-page: 197
  issue: 2
  year: 2018
  ident: 1633_CR303
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiy018
– volume: 90
  start-page: 3253
  issue: 6
  year: 2016
  ident: 1633_CR52
  publication-title: J Virol
  doi: 10.1128/JVI.02582-15
– volume: 11
  start-page: 3180
  issue: 20
  year: 2020
  ident: 1633_CR109
  publication-title: ACS Chem Neurosci
  doi: 10.1021/acschemneuro.0c00596
– volume: 583
  start-page: 282
  issue: 7815
  year: 2020
  ident: 1633_CR41
  publication-title: Nature
  doi: 10.1038/s41586-020-2169-0
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Snippet The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple...
Abstract The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of...
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SubjectTerms Animals
Betacoronavirus 1
Coronavirus
Coronavirus 229E, Human - genetics
Coronavirus 229E, Human - immunology
Coronavirus 229E, Human - pathogenicity
Coronavirus infections
Coronavirus NL63, Human - genetics
Coronavirus NL63, Human - immunology
Coronavirus NL63, Human - pathogenicity
Coronavirus OC43, Human - genetics
Coronavirus OC43, Human - immunology
Coronavirus OC43, Human - pathogenicity
Coronaviruses
COVID-19
COVID-19 - transmission
COVID-19 - virology
COVID-19 Vaccines
disease severity
Disease transmission
Evolution
Genetic aspects
Health aspects
Humans
Immunity
Methods
Middle East respiratory syndrome
Mutation
Mutations
neutralization
Pathogenicity
Prevalence studies (Epidemiology)
Review
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
SARS-CoV-2 - pathogenicity
Selection
Severe acute respiratory syndrome coronavirus 2
Variants
virology
Virus research
virus transmission
viruses
Zoonoses
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Title Evolutionary trajectory of SARS-CoV-2 and emerging variants
URI https://www.ncbi.nlm.nih.gov/pubmed/34389034
https://www.proquest.com/docview/2562612905
https://www.proquest.com/docview/2561482522
https://www.proquest.com/docview/2636779084
https://pubmed.ncbi.nlm.nih.gov/PMC8361246
https://doaj.org/article/139dd79c77634b83a7ad4f0a67e11358
Volume 18
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