Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

• Published in: NeuroImage (Orlando, Fla.) Vol. 244; p. 118639
• Main Authors: Ruhm, Loreen, Avdievich, Nikolai, Ziegs, Theresia, Nagel, Armin M., De Feyter, Henk M., de Graaf, Robin A., Henning, Anke
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; Elsevier Limited; Academic Press; Elsevier
• Subjects: 9.4 Tesla; Alzheimer's disease; Brain; Brain - diagnostic imaging; Deuterium; Deuterium - metabolism; DMI; Experiments; Glucose; Glucose - metabolism; Gray Matter - diagnostic imaging; Human brain; Human subjects; Humans; Magnetic Resonance Imaging - methods; Metabolism; Metabolites; Neuroimaging; Oral glucose administration; Software; Spatial discrimination; TCA cycle; Tricarboxylic acid cycle; Volunteers; Germany; Deuterium; Human brain; DMI; Oral glucose administration; TCA cycle; 9.4 Tesla

To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10...