Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

• Published in: Biological psychiatry (1969) Vol. 87; no. 6; pp. 538 - 547
• Main Authors: Mayo, Leah M., Asratian, Anna, Lindé, Johan, Morena, Maria, Haataja, Roosa, Hammar, Valter, Augier, Gaëlle, Hill, Matthew N., Heilig, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2020
• Subjects: Amidohydrolases; Anandamide; Arachidonic Acids; Biomedical Research; Cannabinoid; Endocannabinoids; Extinction, Psychological; Fatty acid amide hydrolase; Fear; Fear conditioning; Polyunsaturated Alkamides; Psychiatric/Mental Health; PTSD; Stress; PTSD; Fatty acid amide hydrolase; Cannabinoid; Stress; Anandamide; Fear conditioning

Posttraumatic stress disorder, an area of large unmet medical needs, is characterized by persistence of fear memories and maladaptive stress responses. In rodents, elevation of the endocannabinoid anandamide due to inhibition of fatty acid amide hydrolase (FAAH) facilitates fear extinction and prote...