Interleukin-6 induces drug resistance in renal cell carcinoma

• Published in: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE Vol. 64; no. 3; pp. 103 - 110
• Main Authors: Kurimura, Yoshimasa, Koguchi, Tomoyuki, Onagi, Akifumi, Hoshi, Seiji, Matsuoka, Kanako, Takinami-Honda, Ruriko, Hata, Junya, Kojima, Yoshiyuki, Onoda, Mitsutaka, Ishibashi, Kei, Tanji, Ryo, Haga, Nobuhiro, Kataoka, Masao, Ogawsa, Soichiro, Sato, Yuichi
• Format: Journal Article
• Language: English
• Published: Japan THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE 01.01.2018; The Fukushima Society of Medical Science
• Subjects: IFN; IL-6; renal cell carcinoma; Review; SOCS 3; TKI; IFN; renal cell carcinoma; TKI; SOCS 3; IL-6

Metastatic renal cell carcinoma (mRCC) is a tumor entity with poor prognosis due to limited therapy options. Tyrosine kinase inhibitors (TKIs), the novel targeted agents have been used for the treatment of mRCC and have shown efficacy. Interferon (IFN)-α is also one of the most frequently used agent...