Two Novel Adenovirus Vector Systems Permitting Regulated Protein Expression in Gene Transfer Experiments

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Published inJournal of Virology Vol. 72; no. 10; pp. 8358 - 8361
Main Authors Molin, Magnus, Shoshan, Maria C., Öhman-Forslund, Karin, Linder, Stig, Akusjärvi, Göran
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.10.1998
SeriesNote
Subjects
3T3 Cells
Adenoviridae - genetics
Animals
Chloramphenicol O-Acetyltransferase - genetics
COS Cells
Gene Expression Regulation, Viral - drug effects
Gene Therapy
Gene Transfer Techniques
Genetic Vectors
HeLa Cells
Hormone Antagonists - pharmacology
Humans
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Mice
Mifepristone - pharmacology
Tetracycline - pharmacology
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766-1769, 1995) and the RU 486-regulated progesterone antagonist (Wang, Y., et al., Proc. Natl. Acad. Sci. USA 91:8180-8184, 1994)-induced gene expression systems are described. We show that both systems permit a tight control of chloramphenicol acetyltransferase reporter gene expression in a variety of cell types, with induction levels of approximately 1,800-fold (Tet-ON system) and 600-fold (RU 486-regulated system), respectively. A significant advantage of our vector systems is that reporter protein expression can be adjusted over a wide range by varying the amount of inducer. The Tet-ON system is also shown to permit an efficient control of reporter gene expression in mice.
ABSTRACT Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766–1769, 1995) and the RU 486-regulated progesterone antagonist (Wang, Y., et al., Proc. Natl. Acad. Sci. USA 91:8180–8184, 1994)-induced gene expression systems are described. We show that both systems permit a tight control of chloramphenicol acetyltransferase reporter gene expression in a variety of cell types, with induction levels of approximately 1,800-fold (Tet-ON system) and 600-fold (RU 486-regulated system), respectively. A significant advantage of our vector systems is that reporter protein expression can be adjusted over a wide range by varying the amount of inducer. The Tet-ON system is also shown to permit an efficient control of reporter gene expression in mice.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author Göran Akusjärvi
Maria C. Shoshan
Stig Linder
Karin Öhman-Forslund
Magnus Molin
AuthorAffiliation Department of Medical Biochemistry and Microbiology, BMC, Uppsala University, S-751 23 Uppsala, 1 and Radiumhemmet’s Research Laboratory, Cancer Center Karolinska, Karolinska Institute and Hospital, S-171 76 Stockholm, 2 Sweden
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Present address: Department of Virology, The National Veterinary Institute, BMC, S-751 23 Uppsala, Sweden.
Corresponding author. Mailing address: Department of Medical Biochemistry and Microbiology, BMC, Box 582, Uppsala University, S-751 23 Uppsala, Sweden. Phone: 46-18-471 4164. Fax: 46-18-50 98 76. E-mail: goran.akusjarvi@imim.uu.se.
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Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766-1769, 1995) and the RU 486-regulated...
ABSTRACT Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766–1769, 1995) and the RU...
Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766–1769, 1995) and the RU 486-regulated...
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SubjectTerms 3T3 Cells
Adenoviridae - genetics
Animals
Chloramphenicol O-Acetyltransferase - genetics
COS Cells
Gene Expression Regulation, Viral - drug effects
Gene Therapy
Gene Transfer Techniques
Genetic Vectors
HeLa Cells
Hormone Antagonists - pharmacology
Humans
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Mice
Mifepristone - pharmacology
Tetracycline - pharmacology
Title Two Novel Adenovirus Vector Systems Permitting Regulated Protein Expression in Gene Transfer Experiments
URI http://jvi.asm.org/content/72/10/8358.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9733884
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