Co-administration of a meningococcal glycoconjugate ACWY vaccine with travel vaccines: A randomized, open-label, multi-center study

• Published in: Travel medicine and infectious disease Vol. 12; no. 5; pp. 485 - 493
• Main Authors: Alberer, Martin, Burchard, Gerd, Jelinek, Tomas, Reisinger, Emil, Beran, Jiri, Meyer, Seetha, Forleo-Neto, Eduardo, Gniel, Dieter, Dagnew, Alemnew F., Kumar Arora, Ashwani
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2014; Elsevier Limited
• Subjects: Adult; Antimalarials - administration & dosage; Co-administration; Communicable Disease Control - statistics & numerical data; Communicable Diseases - epidemiology; Cross-Sectional Studies; Encephalitis; Female; Humans; Immunogenicity; Infectious Disease; Japanese encephalitis; Male; Meningitis; Meningococcal disease; Meningococcal Infections - prevention & control; Meningococcal Vaccines - administration & dosage; Middle Aged; Mortality; Neisseria meningitidis; Neutralization; Rabies; Safety; Travel; Travel - statistics & numerical data; Travel Medicine; Vaccination - statistics & numerical data; Vaccine; Vaccines; Vaccines - administration & dosage; Vaccines, Conjugate - administration & dosage; Vector-borne diseases; Young Adult; Asia; LL; PP; Co-administration; PCECV; AE; CI; Vaccine; GMT; Rabies; SAE; MITT; hSBA; JEV; JE; GMC; Meningococcal disease; Japanese encephalitis; geometric mean concentration; serum bactericidal activities with human complement; modified intent to treat population; geometric mean titer; Lower limit; serious adverse event; per-protocol set; adverse event; Japanese encephalitis vaccine; purified chick embryo cell culture derived rabies vaccine; confidence interval

Potential interactions between vaccines may compromise the immunogenicity and/or safety of individual vaccines so must be assessed before concomitant administration is recommended. In this study, the immunogenicity and safety of travel vaccines against Japanese encephalitis (JEV) and rabies (PCECV)...