Mitochondrial dysfunction: roles in skeletal muscle atrophy

• Published in: Journal of translational medicine Vol. 21; no. 1; pp. 503 - 24
• Main Authors: Chen, Xin, Ji, Yanan, Liu, Ruiqi, Zhu, Xucheng, Wang, Kexin, Yang, Xiaoming, Liu, Boya, Gao, Zihui, Huang, Yan, Shen, Yuntian, Liu, Hua, Sun, Hualin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.07.2023; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; Aging; AKT protein; Analysis; Antioxidants; Atrophy; Atrophy, Muscular; Autophagy; Care and treatment; Cell therapy; Denervation; Diagnosis; Drug therapy; Enzymes; Gene therapy; Homeostasis; Inflammation; Insulin-like growth factor I; Insulin-like growth factors; Kinases; Metabolism; Methods; Mitochondria; Mitochondrial DNA; Mitochondrial dysfunction; Molecular modelling; Muscle atrophy; Musculoskeletal system; NF-κB protein; Oxidation; Oxidative stress; Physiology, Pathological; Protein synthesis; Proteins; Proteolysis; Review; SIRT1 protein; Skeletal muscle; Smad2 protein; Stat3 protein; Stem cells; Therapy; TOR protein; Transforming growth factor-b; Transplantation; Tumor necrosis factor-TNF; China; Antioxidants; Therapy; Muscle atrophy; Mitochondrial dysfunction

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can lead to skeletal muscle atrophy, and its molecular mechanism leading to skeletal muscle atrop...