506-P: Branched-Chain Amino Acids Promote Occurrence and Development of Cardiovascular Disease Dependent on Triglyceride Metabolism via Activation of the mTOR/SREBP-1/Betatrophin Pathway

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. Supplement_1; p. 1
• Main Authors: ZHANG, JIE, HU, WEN
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 14.06.2024
• Subjects: AKT protein; Amino acids; Cardiovascular disease; Cardiovascular diseases; Diabetes mellitus; Diet; Disease resistance; Fatty liver; Insulin resistance; Liver diseases; Metabolism; Metformin; Signal transduction; Sterol regulatory element-binding protein; TOR protein

Background: Branched-chain amino acids (BCAAs) has been associated with the development of cardiovascular disease (CVD). However, the underlying mechanism remains uncertain. Methods: The clinical study included 1302 subjects guided by diet and exercise intervention for 4 years and subsequent follow-...